Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson’s Disease and Diabetes as Well as Potential Therapies?

Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

(2018) Ivan Martinez-Valbuena et al.   ACTA NEUROPATHOLOGICA

Association between diabetes and subsequent Parkinson disease

(2018) Eduardo De Pablo-Fernandez et al.   NEUROLOGY

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

(2018) Nicole K. Polinski et al.   Journal of Parkinsons Disease

Stimulation of Insulin Signaling and Inhibition of JNK-AP1 Activation Protect Cells from Amyloid-β-Induced Signaling Dysregulation and Inflammatory Response

(2018) Michelle Bamji-Mirza et al.   JOURNAL OF ALZHEIMERS DISEASE

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FTY720-derivatives do not induce FTY720-like lymphopenia

(2017) Ismael Segura-Ulate et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells

(2017) Ismael Segura-Ulate et al.   NEUROPHARMACOLOGY

Biological and Clinical Implications of Comorbidities in Parkinson’s Disease

(2017) Jose A. Santiago et al.   Frontiers in Aging Neuroscience

Inflammatory Regulation in Diabetes and Metabolic Dysfunction

(2017) Jixin Zhong et al.   Journal of Diabetes Research

FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice

(2016) Guadalupe Vidal-Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

(2016) Julius O. Enoru et al.   PLoS One

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

(2016) Istvan Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance and Parkinson’s disease: A new target for disease modification?

(2016) D. Athauda et al.   PROGRESS IN NEUROBIOLOGY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

(2016) Timothy J. Collier et al.   Frontiers in Neuroscience

Midbrain dopamine neurons in Parkinson׳s disease exhibit a dysregulated miRNA and target-gene network

(2015) Christine E. Briggs et al.   BRAIN RESEARCH

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling

(2015) Shanshan Gao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

FTY720 attenuates excitotoxicity and neuroinflammation

(2015) Raffaela Cipriani et al.   Journal of Neuroinflammation

Subcellular Localization of K+ Channels in Mammalian Brain Neurons: Remarkable Precision in the Midst of Extraordinary Complexity

(2015) James S. Trimmer   NEURON

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

(2015) Melissa A. Stouffer et al.   Nature Communications

Does Parkinson’s Disease and Type-2 Diabetes Mellitus Present Common Pathophysiological Mechanisms and Treatments?

(2014) Marcelo Lima et al.   CNS & Neurological Disorders-Drug Targets

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling

(2014) Woori Kim et al.   NEUROBIOLOGY OF AGING

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

(2014) Pei Zhang et al.   Oxidative Medicine and Cellular Longevity

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells

(2014) Javier Vargas-Medrano et al.   ACS Medicinal Chemistry Letters

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

(2013) J. J. Oaks et al.   BLOOD

Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

(2013) Kaitlin F. Farrell et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Entry and  -Synuclein Inclusions Elevate Dendritic Mitochondrial Oxidant Stress in Dopaminergic Neurons

(2013) D. I. Dryanovski et al.   JOURNAL OF NEUROSCIENCE

Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice

(2013) Sarah M. Rothman et al.   NEUROBIOLOGY OF AGING

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Parkinson's disease, insulin resistance and novel agents of neuroprotection

(2012) Iciar Aviles-Olmos et al.   BRAIN

FTY720 preserved isletβ-cell mass by inhibiting apoptosis and increasing survival ofβ-cells in db/db mice

(2012) Hosik Moon et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretionin Vitro

(2012) Norman Simpson et al.   MOLECULAR ENDOCRINOLOGY

Diabetes and risk of Parkinson's disease

(2012) Emanuele Cereda et al.   MOVEMENT DISORDERS

Clinical Features of Parkinson Disease when Onset of Diabetes Came First: A Case-Control Study

(2012) K. Kawabe et al.   NEUROLOGY

Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo

(2012) J. Wu et al.   NEUROSCIENCE

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes and Risk of Parkinson's Disease: A systematic review and meta-analysis

(2011) E. Cereda et al.   DIABETES CARE

Diabetes and the Risk of Developing Parkinson's Disease in Denmark

(2011) E. Schernhammer et al.   DIABETES CARE

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

(2011) Hye Jung Kim et al.   FASEB JOURNAL

Synuclein modulation of monoamine transporters

(2011) Adam W. Oaks et al.   FEBS LETTERS

FTY720 Normalizes Hyperglycemia by Stimulating β-Cellin VivoRegeneration indb/dbMice through Regulation of Cyclin D3 and p57KIP2

(2011) Zhengshan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Accelerated Autoimmune Diabetes in the Absence of LAG-3

(2011) M. Bettini et al.   JOURNAL OF IMMUNOLOGY

Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels

(2011) Jyoti C. Patel et al.   JOURNAL OF NEUROCHEMISTRY

 -Synuclein Negatively Regulates Protein Kinase C  Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

(2011) H. Jin et al.   JOURNAL OF NEUROSCIENCE

Obesity, diabetes, and risk of Parkinson's disease

(2011) Natalia Palacios et al.   MOVEMENT DISORDERS

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

α-Synuclein Promotes Neuroprotection Through NF-κB–Mediated Transcriptional Regulation of Protein Kinase Cδ

(2011) Reina Aoki et al.   Science Signaling

α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion

(2010) Xuehui Geng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo

(2010) Haiyan Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

(2010) Oleg S Gorbatyuk et al.   MOLECULAR THERAPY

α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

(2010) Oleg S Gorbatyuk et al.   MOLECULAR THERAPY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

14-3-3ζ Contributes to Tyrosine Hydroxylase Activity in MN9D Cells

(2009) Jian Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for a novel protein, nucleolin, in Parkinson's disease

(2009) W. Michael Caudle et al.   NEUROSCIENCE LETTERS

Prospective Cohort Study of Type 2 Diabetes and the Risk of Parkinson's Disease

(2008) J. A. Driver et al.   DIABETES CARE

FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice

(2008)   DIABETES OBESITY & METABOLISM

Central nervous system-directed effects of FTY720 (fingolimod)

(2008) Veronique E. Miron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Kir6.2 knockout alters neurotransmitter release in mouse striatum: An in vivo microdialysis study

(2008) Xue-Ru Shi et al.   NEUROSCIENCE LETTERS

α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

(2008) Tshianda N.M. Alerte et al.   NEUROSCIENCE LETTERS

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING