The Gut and Parkinson’s Disease: Hype or Hope?

The concept of alpha-synuclein as a prion-like protein: ten years after

(2018) Jennifer A. Steiner et al.   CELL AND TISSUE RESEARCH

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

(2018) Karoline Knudsen et al.   LANCET NEUROLOGY

Gastrointestinal nervous system α-synuclein as a potential biomarker of Parkinson disease

(2018) Fudong Yan et al.   MEDICINE

Detecting Alpha Synuclein Seeding Activity in Formaldehyde-Fixed MSA Patient Tissue by PMCA

(2018) Katelyn Becker et al.   MOLECULAR NEUROBIOLOGY

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease

(2018) C. Ruffmann et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

(2018) Christopher M Dussik et al.   Journal of Neurogastroenterology and Motility

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients

(2018) Ariadna Recasens et al.   Acta Neuropathologica Communications

Alpha-synuclein staining in non-neural structures of the gastrointestinal tract is non-specific in Parkinson disease

(2018) Chaewon Shin et al.   PARKINSONISM & RELATED DISORDERS

More than constipation - bowel symptoms in Parkinson's disease and their connection to gut microbiota

(2017) T. H. Mertsalmi et al.   EUROPEAN JOURNAL OF NEUROLOGY

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

(2017) Isabel Paiva et al.   HUMAN MOLECULAR GENETICS

Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1

(2017) Jiaming Liu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology

(2017) Per Borghammer   MOVEMENT DISORDERS

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease

(2017) Laurène Leclair-Visonneau et al.   NEUROLOGY

Decreased intestinal acetylcholinesterase in early Parkinson disease

(2017) Tatyana D. Fedorova et al.   NEUROLOGY

Biochemical analysis of α-synuclein extracted from control and Parkinson’s disease colonic biopsies

(2017) Anne-Gaëlle Corbillé et al.   NEUROSCIENCE LETTERS

Oral and nasal microbiota in Parkinson's disease

(2017) Pedro A.B. Pereira et al.   PARKINSONISM & RELATED DISORDERS

Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson’s disease: Comparison with surgical specimens

(2017) Chaewon Shin et al.   PARKINSONISM & RELATED DISORDERS

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy

(2017) Phillip A. Engen et al.   Journal of Parkinsons Disease

Objective Colonic Dysfunction is Far more Prevalent than Subjective Constipation in Parkinson’s Disease: A Colon Transit and Volume Study

(2017) Karoline Knudsen et al.   Journal of Parkinsons Disease

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

(2017) Mohammad Shahnawaz et al.   JAMA Neurology

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Cross-linking for the analysis of α-synuclein in the enteric nervous system

(2016) Anne-Gaëlle Corbillé et al.   JOURNAL OF NEUROCHEMISTRY

Orthostatic hypotension and cardiac sympathetic denervation in Parkinson disease patients with REM sleep behavioral disorder

(2016) Joong-Seok Kim et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation

(2016) Sara Breid et al.   JOURNAL OF VIROLOGY

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

(2016) Jacob I. Ayers et al.   JOURNAL OF VIROLOGY

Neuropathological basis of nonmotor manifestations of Parkinson's disease

(2016) Charles H. Adler et al.   MOVEMENT DISORDERS

What a gastrointestinal biopsy can tell us about Parkinson's disease?

(2016) A.-G. Corbillé et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Probiotics and prebiotic fiber for constipation associated with Parkinson disease

(2016) Michela Barichella et al.   NEUROLOGY

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects

(2016) Thomas G. Beach et al.   Journal of Parkinsons Disease

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates

(2015) Doris Vandeputte et al.   GUT

Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker

(2015) Sun Ju Chung et al.   MOVEMENT DISORDERS

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Colonic mucosal  -synuclein lacks specificity as a biomarker for Parkinson disease

(2015) N. P. Visanji et al.   NEUROLOGY

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

(2015) Iban Aldecoa et al.   NEUROSCIENCE LETTERS

The microbiome of the human lower airways: a next generation sequencing perspective

(2015) Velma T. E. Aho et al.   World Allergy Organization Journal

Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

(2015) Thomas Clairembault et al.   Acta Neuropathologica Communications

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

Enteric GFAP expression and phosphorylation in Parkinson's disease

(2014) Thomas Clairembault et al.   JOURNAL OF NEUROCHEMISTRY

In vivo gastric detection of α-synuclein inclusions in Parkinson's disease

(2014) Álvaro Sánchez-Ferro et al.   MOVEMENT DISORDERS

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

The role of small intestinal bacterial overgrowth in Parkinson's disease

(2013) Alfonso Fasano et al.   MOVEMENT DISORDERS

Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson’s disease

(2013) R. St. Laurent et al.   NEUROSCIENCE

Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss

(2012) Dana M. Annerino et al.   ACTA NEUROPATHOLOGICA

The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease

(2012) Michel Neunlist et al.   Nature Reviews Gastroenterology & Hepatology

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

(2011) Christopher B. Forsyth et al.   PLoS One

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Relationship between 123I-MIBG scintigrams and REM sleep behavior disorder in Parkinson’s disease

(2010) Takashi Nomura et al.   PARKINSONISM & RELATED DISORDERS

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One