Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection

Long-Term Exercise Modulates Hippocampal Gene Expression in Senescent Female Mice

(2018) María Jesús Alvarez-López et al.   JOURNAL OF ALZHEIMERS DISEASE

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor  B-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning

(2016) R. Neidl et al.   JOURNAL OF NEUROSCIENCE

DNA Demethylation Upregulated Nrf2 Expression in Alzheimer’s Disease Cellular Model

(2016) Huimin Cao et al.   Frontiers in Aging Neuroscience

Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8)

(2015) Christian Griñan-Ferré et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology

(2015) Aurel Popa-Wagner et al.   Neural Regeneration Research

Morris Water Maze Training in Mice Elevates Hippocampal Levels of Transcription Factors Nuclear Factor (Erythroid-derived 2)-like 2 and Nuclear Factor Kappa B p65

(2015) Wanda M. Snow et al.   Frontiers in Molecular Neuroscience

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus

(2014) Hasan Irier et al.   GENOMICS

Selective role for DNMT3a in learning and memory

(2014) Michael J. Morris et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise

(2014) Marta Cosín-Tomás et al.   Frontiers in Aging Neuroscience

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model

(2013) Xiao-rui Cheng et al.   AGEING RESEARCH REVIEWS

Preclinical models of stroke in aged animals with or without comorbidities: role of neuroinflammation

(2013) A.-M. Buga et al.   BIOGERONTOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Standardized Extract ofBacopa monnieraAttenuates Okadaic Acid Induced Memory Dysfunction in Rats: Effect on Nrf2 Pathway

(2013) Subhash Dwivedi et al.   Evidence-based Complementary and Alternative Medicine

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models

(2013) B Barak et al.   Translational Psychiatry

Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus

(2012) Lauren L. Williamson et al.   BRAIN BEHAVIOR AND IMMUNITY

Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection

(2012) Heidi A. Jurgens et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

(2012) Romain Barrès et al.   Cell Metabolism

The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease

(2012) John E. Morley et al.   CURRENT PHARMACEUTICAL DESIGN

Aldehyde oxidase 1 gene is regulated by Nrf2 pathway

(2012) Kenichiro Maeda et al.   GENE

The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells against Apoptosis through Activation of the Extracellular Signal-regulated Kinase (ERK)/NRF2 Signaling Pathway and Cytokine Release

(2012) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal Histone Acetylation Regulates Object Recognition and the Estradiol-Induced Enhancement of Object Recognition

(2012) Z. Zhao et al.   JOURNAL OF NEUROSCIENCE

Enhanced Expression of Glia Maturation Factor Correlates with Glial Activation in the Brain of Triple Transgenic Alzheimer’s Disease Mice

(2012) Smita Zaheer et al.   NEUROCHEMICAL RESEARCH

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

(2011) John E. Morley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prolonged Exposure to Particulate Pollution, Genes Associated with Glutathione Pathways, and DNA Methylation in a Cohort of Older Men

(2011) Jaime Madrigano et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

(2011) Rosa Cristòfol et al.   JOURNAL OF PINEAL RESEARCH

HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

(2011) J. Haettig et al.   LEARNING & MEMORY

Methylation on the mind

(2011) Jonathan D Flax et al.   NATURE NEUROSCIENCE

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

The path to epigenetic treatment of memory disorders

(2011) Mikael A. Mikaelsson et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

DNA methylation and memory formation

(2010) Jeremy J Day et al.   NATURE NEUROSCIENCE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma

(2009) Carmen J. Marsit et al.   CARCINOGENESIS

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice

(2009) Toshio Takeda   NEUROCHEMICAL RESEARCH

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

Modulation of long-term memory for object recognition via HDAC inhibition

(2009) D. P. Stefanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Genetics of Alzheimer's disease: recent advances

(2009) Dimitrios Avramopoulos   Genome Medicine

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

DNA methylation impacts on learning and memory in aging

(2007) Liang Liu et al.   NEUROBIOLOGY OF AGING