Astrocytes in chronic pain and itch

Astrocyte activation in the periaqueductal gray promotes descending facilitation to cancer-induced bone pain through the JNK MAPK signaling pathway

(2019) Hua-dong Ni et al.   Molecular Pain

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

(2018) Ru-Rong Ji et al.   ANESTHESIOLOGY

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

(2018) Xin Luo et al.   BRAIN BEHAVIOR AND IMMUNITY

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

(2018) Norio Takata et al.   GLIA

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

(2018) Katherine Stockstill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A glial blueprint for gliomagenesis

(2018) Dylan Laug et al.   NATURE REVIEWS NEUROSCIENCE

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Peripheral and Central Mechanisms of Itch

(2018) Xintong Dong et al.   NEURON

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

(2018) Qingjian Han et al.   NEURON

Voluntary running enhances glymphatic influx in awake behaving, young mice

(2018) Stephanie von Holstein-Rathlou et al.   NEUROSCIENCE LETTERS

Astrocytes in the spinal dorsal horn and chronic itch

(2018) Makoto Tsuda   NEUROSCIENCE RESEARCH

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Nav1.5 in astrocytes plays a sex-specific role in clinical outcomes in a mouse model of multiple sclerosis

(2018) Laura W. Pappalardo et al.   GLIA

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Microglial pannexin-1 channel activation is a spinal determinant of joint pain

(2018) Michael Mousseau et al.   Science Advances

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice

(2017) Norimitsu Morioka et al.   GLIA

Assessment of the dynamics of human glymphatic system by near-infrared spectroscopy

(2017) Teemu Myllylä et al.   Journal of Biophotonics

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats

(2017) Lai Jiang et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Decreased alertness due to sleep loss increases pain sensitivity in mice

(2017) Chloe Alexandre et al.   NATURE MEDICINE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Spinal Circuits Transmitting Mechanical Pain and Itch

(2017) Bo Duan et al.   Neuroscience Bulletin

TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms

(2017) Xiuhua Miao et al.   Neuroscience Bulletin

Chemokine Receptor CXCR3 in the Spinal Cord Contributes to Chronic Itch in Mice

(2017) Peng-Bo Jing et al.   Neuroscience Bulletin

Modulation of Pain and Itch by Spinal Glia

(2017) Makoto Tsuda   Neuroscience Bulletin

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms

(2017) Rou-Gang Xie et al.   Neuroscience Bulletin

A role for the purinergic receptor P2X3 in astrocytes in the mechanism of craniofacial neuropathic pain

(2017) Won Mah et al.   Scientific Reports

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

(2016) Sandeep K. Singh et al.   CELL

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain

(2016) Ana C. Zarpelon et al.   FASEB JOURNAL

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain

(2016) Sun Kwang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis

(2016) George Tackley et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Chronic Neuropathic Pain: It's about the Rhythm

(2016) Z. Alshelh et al.   JOURNAL OF NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice

(2016) Tong Liu et al.   PAIN

IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy

(2016) Boyi Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gliogenic LTP spreads widely in nociceptive pathways

(2016) M. T. Kronschlager et al.   SCIENCE

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

(2016) Satoru Koyanagi et al.   Nature Communications

Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

(2016) Youngpyo Nam et al.   Cell Reports

Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions

(2016) Chien-Cheng Liu et al.   Scientific Reports

Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII–CREB and Astroglial JAK2–STAT3 Cascades in Mice

(2015) Shenbin Liu et al.   ANESTHESIOLOGY

Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus

(2015) Masafumi Kimura et al.   ANESTHESIOLOGY

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury

(2015) Aditi Falnikar et al.   GLIA

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

(2015) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Delayed Activation of Spinal Microglia Contributes to the Maintenance of Bone Cancer Pain in Female Wistar Rats via P2X7 Receptor and IL-18

(2015) Y. Yang et al.   JOURNAL OF NEUROSCIENCE

Supporting itch: a new role for astrocytes in chronic itch

(2015) Dustin Green et al.   NATURE MEDICINE

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

(2015) Miho Shiratori-Hayashi et al.   NATURE MEDICINE

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats

(2015) Su Liu et al.   PAIN

A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch

(2015) Tasuku Akiyama et al.   PAIN

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

(2015) S. Bourane et al.   SCIENCE

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates

(2015) Heeseung Lee et al.   Scientific Reports

Long-term Therapy With Interleukin 6 Receptor Blockade in Highly Active Neuromyelitis Optica Spectrum Disorder

(2015) Marius Ringelstein et al.   JAMA Neurology

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

(2014) Suzana Herculano-Houzel   GLIA

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

(2014) T. Fujita et al.   JOURNAL OF NEUROSCIENCE

A Pain Research Agenda for the 21st Century

(2014) Robert W. Gereau et al.   JOURNAL OF PAIN

Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2014) Yan Li et al.   JOURNAL OF PAIN

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Pain in neuromyelitis optica—prevalence, pathogenesis and therapy

(2014) Monika Bradl et al.   Nature Reviews Neurology

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

(2014) C.R. Robinson et al.   NEUROSCIENCE

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling

(2014) Ying Lu et al.   PAIN

Astroglial cradle in the life of the synapse

(2014) A. Verkhratsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Long-term potentiation of glycinergic synapses triggered by interleukin 1 

(2014) A. M. Chirila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Cord Stimulation Reduces Mechanical Hyperalgesia and Glial Cell Activation in Animals with Neuropathic Pain

(2013) Karina L. Sato et al.   ANESTHESIA AND ANALGESIA

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

(2013) Zhen-Zhong Xu et al.   ANNALS OF NEUROLOGY

Sex differences in pain: a brief review of clinical and experimental findings

(2013) E.J. Bartley et al.   BRITISH JOURNAL OF ANAESTHESIA

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

WNT signaling underlies the pathogenesis of neuropathic pain in rodents

(2013) Yan-Kai Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Itch and Analgesia Resulting from Intrathecal Application of Morphine: Contrasting Effects on Different Populations of Trigeminothalamic Tract Neurons

(2013) H. R. Moser et al.   JOURNAL OF NEUROSCIENCE

Induction of Thermal Hyperalgesia and Synaptic Long-Term Potentiation in the Spinal Cord Lamina I by TNF-  and IL-1  is Mediated by Glial Cells

(2013) D. Gruber-Schoffnegger et al.   JOURNAL OF NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Sensory neurons and circuits mediating itch

(2013) Robert H. LaMotte et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Pruritus

(2013) Gil Yosipovitch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

(2013) Zhi-Jun Zhang et al.   PAIN

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

(2013) Tong Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Spinal Actions of Lipoxin A4 and 17(R)-Resolvin D1 Attenuate Inflammation-Induced Mechanical Hypersensitivity and Spinal TNF Release

(2013) Sally Abdelmoaty et al.   PLoS One

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Astrocytes and disease: a neurodevelopmental perspective

(2012) A. V. Molofsky et al.   GENES & DEVELOPMENT

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

(2012) Michael J. Chen et al.   GLIA

Artifact versus reality-How astrocytes contribute to synaptic events

(2012) Maiken Nedergaard et al.   GLIA

Wnt Signaling in the Pathogenesis of Multiple Sclerosis-Associated Chronic Pain

(2012) Subo Yuan et al.   Journal of Neuroimmune Pharmacology

Thrombospondin-4 Contributes to Spinal Sensitization and Neuropathic Pain States

(2012) D.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

Critical Role of Connexin 43 in Secondary Expansion of Traumatic Spinal Cord Injury

(2012) C. Huang et al.   JOURNAL OF NEUROSCIENCE

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Evidence That Spinal Astrocytes but Not Microglia Contribute to the Pathogenesis of Paclitaxel-Induced Painful Neuropathy

(2012) Haijun Zhang et al.   JOURNAL OF PAIN

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin

(2012) Gary J. Patti et al.   Nature Chemical Biology

Role of Astrocytes in Pain

(2012) C.-Y. Chiang et al.   NEUROCHEMICAL RESEARCH

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model

(2011) Feng-Li Chen et al.   BRAIN RESEARCH BULLETIN

Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease

(2011) Sarah E Ross   CURRENT OPINION IN NEUROBIOLOGY

Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats

(2011) Young S. Gwak et al.   EXPERIMENTAL NEUROLOGY

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

(2011) Xiao-Peng Mei et al.   Journal of Neuroinflammation

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Gliotransmission Modulates Baseline Mechanical Nociception

(2011) Jeannine C Foley et al.   Molecular Pain

Mechanisms Involved in Extraterritorial Facial Pain following Cervical Spinal Nerve Injury in Rats

(2011) Azusa Kobayashi et al.   Molecular Pain

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hypoalgesia in mice lacking aquaporin-4 water channels

(2010) Feng Bao et al.   BRAIN RESEARCH BULLETIN

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

(2010) Yong-Jing Gao et al.   GLIA

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor- 

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

(2010) Nanna Goldman et al.   NATURE NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Functions of astrocytes and their potential as therapeutic targets

(2010) Harold K. Kimelberg et al.   Neurotherapeutics

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

(2010) J. M. Garre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

(2009) Yong-Jing Gao et al.   EXPERIMENTAL NEUROLOGY

Astroglia in Medullary Dorsal Horn (Trigeminal Spinal Subnucleus Caudalis) Are Involved in Trigeminal Neuropathic Pain Mechanisms

(2009) A. Okada-Ogawa et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Plasticity in Expression of the Glutamate Transporters GLT-1 and GLAST in Spinal Dorsal Horn Glial Cells following Partial Sciatic Nerve Ligation

(2009) Wen-Jun Xin et al.   Molecular Pain

Current Challenges in Glia-Pain Biology

(2009) Stephen B. McMahon et al.   NEURON

Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acetic protein in maintenance of pain behaviors

(2009) Doo-sik Kim et al.   PAIN

The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome

(2009) Wen-Wu Li et al.   PAIN

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

(2009) Yong-Jing Gao et al.   PAIN

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Matrix metalloprotease regulation of neuropathic pain

(2009) Ru-Rong Ji et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome

(2008) Luis Del Valle et al.   BRAIN BEHAVIOR AND IMMUNITY

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Identification of Positionally Distinct Astrocyte Subtypes whose Identities Are Specified by a Homeodomain Code

(2008) Christian Hochstim et al.   CELL

Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury

(2008) Hirokazu Katsura et al.   GLIA

Evidence for a Role of Connexin 43 in Trigeminal Pain Using RNA Interference In Vivo

(2008) Peter T. Ohara et al.   JOURNAL OF NEUROPHYSIOLOGY

Interleukin-18-Mediated Microglia/Astrocyte Interaction in the Spinal Cord Enhances Neuropathic Pain Processing after Nerve Injury

(2008) K. Miyoshi et al.   JOURNAL OF NEUROSCIENCE

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Connexin 43 Hemichannels Are Permeable to ATP

(2008) J. Kang et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Loss of Astrocytic Domain Organization in the Epileptic Brain

(2008) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury

(2008) Michael Cronin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats

(2007) Rui-Xin Zhang et al.   PAIN