Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gliogenic LTP spreads widely in nociceptive pathways

(2016) M. T. Kronschlager et al.   SCIENCE

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

(2016) Gang Chen et al.   Nature Communications

Upregulation of Chemokine CXCL12 in the Dorsal Root Ganglia and Spinal Cord Contributes to the Development and Maintenance of Neuropathic Pain Following Spared Nerve Injury in Rats

(2016) Liying Bai et al.   Neuroscience Bulletin

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation

(2016) Xing-Jun Liu et al.   Scientific Reports

Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions

(2016) Chien-Cheng Liu et al.   Scientific Reports

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Synaptic plasticity in pathological pain

(2014) Ceng Luo et al.   TRENDS IN NEUROSCIENCES

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

(2013) Zhen-Zhong Xu et al.   ANNALS OF NEUROLOGY

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels

(2013) P. Pagadala et al.   JOURNAL OF NEUROSCIENCE

Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain

(2013) Xisheng Yan et al.   JOURNAL OF PHYSIOLOGY-LONDON

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

(2012) Emika Toyomitsu et al.   Purinergic Signalling

Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation

(2012) Wei Guo et al.   Neuroscience Bulletin

Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC

(2012) Fei Dong et al.   Neuroscience Bulletin

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses

(2010) Yu-Xia Chu et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach

(2010) Toshiharu Yasaka et al.   PAIN

TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2

(2010) Ling Zhang et al.   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Visualization of Chemokine Receptor Activation in Transgenic Mice Reveals Peripheral Activation of CCR2 Receptors in States of Neuropathic Pain

(2009) H. Jung et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Chemokines and pain mechanisms

(2008) Catherine Abbadie et al.   BRAIN RESEARCH REVIEWS

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE