Nav1.5 in astrocytes plays a sex-specific role in clinical outcomes in a mouse model of multiple sclerosis

Sodium channels in astroglia and microglia

(2016) Laura W. Pappalardo et al.   GLIA

Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial

(2016) Rhian Raftopoulos et al.   LANCET NEUROLOGY

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Control of autoimmune CNS inflammation by astrocytes

(2015) Veit Rothhammer et al.   Seminars in Immunopathology

Voltage-gated sodium channel Nav1.5 contributes to astrogliosis in anin vitromodel of glial injury via reverse Na+/Ca2+exchange

(2014) Laura W. Pappalardo et al.   GLIA

Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP-stimulated microglia

(2014) Anna-Karin Persson et al.   GLIA

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

The neuroprotective actions of oestradiol and oestrogen receptors

(2014) Maria-Angeles Arevalo et al.   NATURE REVIEWS NEUROSCIENCE

Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis

(2014) Laura W. Pappalardo et al.   NEUROREPORT

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

(2014) Zhida Su et al.   Nature Communications

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis

(2013) Damineh Morsali et al.   BRAIN

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis

(2013) Marijke Stevens et al.   JOURNAL OF NEUROIMMUNOLOGY

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER  Signaling on Astrocytes But Not through ER  Signaling on Astrocytes or Neurons

(2013) R. D. Spence et al.   JOURNAL OF NEUROSCIENCE

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators

(2013) Michael V. Sofroniew   NEUROSCIENTIST

Nav1.5 sodium channels in macrophages in multiple sclerosis lesions

(2012) Joel A Black et al.   Multiple Sclerosis Journal

A voltage-gated sodium channel is essential for the positive selection of CD4+ T cells

(2012) Wan-Lin Lo et al.   NATURE IMMUNOLOGY

Animal models of multiple sclerosis: the good, the bad and the bottom line

(2012) Richard M Ransohoff   NATURE NEUROSCIENCE

Sex-related factors in multiple sclerosis susceptibility and progression

(2012) Rhonda R. Voskuhl et al.   Nature Reviews Neurology

Sodium channels and microglial function

(2011) Joel A. Black et al.   EXPERIMENTAL NEUROLOGY

The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations

(2011) Lisette M. Carrithers et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

(2011) Rory D. Spence et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Deletion of Astroglial Dicer Causes Non-Cell-Autonomous Neuronal Dysfunction and Degeneration

(2011) J. Tao et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic mechanisms and experimental models of multiple sclerosis

(2010) Anthony Slavin et al.   AUTOIMMUNITY

Mouse models for multiple sclerosis: Historical facts and future implications

(2010) Andrew L. Croxford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5

(2010) J. A. Black et al.   BRAIN

Inhibition of reactive astrocytosis in established experimental autoimmune encephalomyelitis favors infiltration by myeloid cells over T cells and enhances severity of disease

(2010) Henrik Toft-Hansen et al.   GLIA

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial

(2010) Raju Kapoor et al.   LANCET NEUROLOGY

Estrogen Actions on Neuroendocrine Glia

(2010) Paul Micevych et al.   NEUROENDOCRINOLOGY

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of multiple sclerosis—Potentials and limitations

(2010) Eilhard Mix et al.   PROGRESS IN NEUROBIOLOGY

Neurodegeneration in autoimmune CNS inflammation

(2009) Josephine Herz et al.   EXPERIMENTAL NEUROLOGY

Sodium channel activity modulates multiple functions in microglia

(2009) Joel A. Black et al.   GLIA

Regulation of Podosome Formation in Macrophages by a Splice Variant of the Sodium ChannelSCN8A

(2009) Michael D. Carrithers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

NaV1.5 sodium channels in a human microglial cell line

(2009) E. Nicholson et al.   JOURNAL OF NEUROIMMUNOLOGY

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE