Emerging role of Toll-like receptors in the control of pain and itch

The Impact of Pruritus on Quality of Life

(2011) Seema P. Kini   ARCHIVES OF DERMATOLOGY

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

(2011) Makoto Tsuda et al.   BRAIN

Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain

(2011) Wei Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation

(2011) Feng-Yu Liu et al.   BRAIN RESEARCH

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Molecular signals of plasticity at the tetrapartite synapse

(2011) Alexander Dityatev et al.   CURRENT OPINION IN NEUROBIOLOGY

Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats

(2011) Xin Kuang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Resolving TRPV1- and TNF- -Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Microglia: A Promising Target for Treating Neuropathic and Postoperative Pain, and Morphine Tolerance

(2011) Yeong-Ray Wen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Role of Astrocytes in Neurovascular Coupling

(2011) Gabor C. Petzold et al.   NEURON

Ketamine Depresses Toll-Like Receptor 3 Signaling in Spinal Microglia in a Rat Model of Neuropathic Pain

(2011) Xiao-Peng Mei et al.   NEUROSIGNALS

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

(2011) Christina A. Christianson et al.   PAIN

TLR1/TLR2 Heterodimers Play an Important Role in the Recognition of Borrelia Spirochetes

(2011) Marije Oosting et al.   PLoS One

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

History of pain theories

(2011) Jun Chen   Neuroscience Bulletin

Chronic Pruritus in the Absence of Specific Skin Disease

(2010) Nicoletta Cassano et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Release of Prostaglandin E2 and Nitric Oxide from Spinal Microglia Is Dependent on Activation of p38 Mitogen-Activated Protein Kinase

(2010) Tomohiro Matsui et al.   ANESTHESIA AND ANALGESIA

Dorsal Horn α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Trafficking in Inflammatory Pain

(2010) Yuan-Xiang Tao   ANESTHESIOLOGY

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat

(2010) Li-Jun Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

Spinal glial TLR4-mediated nociception and production of prostaglandin E2 and TNF

(2010) O Saito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres

(2010) Natalia Popa et al.   GLIA

Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs

(2010) Elad H. Kaufman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lipopolysaccharide From Porphyromonas gingivalis Sensitizes Capsaicin-Sensitive Nociceptors

(2010) Caio Cezar Randi Ferraz et al.   JOURNAL OF ENDODONTICS

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Down-Regulation of Toll-Like Receptor 4 Gene Expression by Short Interfering RNA Attenuates Bone Cancer Pain in a Rat Model

(2010) Liu Si Lan et al.   Molecular Pain

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

(2010) Xiaoxia Z. West et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Truncal Pruritus of Unknown Origin May Be a Symptom of Diabetic Polyneuropathy

(2009) H. Yamaoka et al.   DIABETES CARE

Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch

(2009) Feng Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Peripheral Nerve Injury Sensitizes Neonatal Dorsal Horn Neurons to Tumor Necrosis Factor-α

(2009) Jie Li et al.   Molecular Pain

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

(2009) Yong-Jing Gao et al.   PAIN

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Matrix metalloprotease regulation of neuropathic pain

(2009) Ru-Rong Ji et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Neuronal nociceptive responses in thalamocortical pathways

(2009) Fei Luo et al.   Neuroscience Bulletin

Roles of the hippocampal formation in pain information processing

(2009) Ming-Gang Liu et al.   Neuroscience Bulletin

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Neuron–glia crosstalk gets serious: role in pain hypersensitivity

(2008) Ke Ren et al.   Current Opinion in Anesthesiology

BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn

(2008) Li-Jun Zhou et al.   EXPERIMENTAL NEUROLOGY

Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes

(2008) Hyemi Kim et al.   IMMUNOLOGY

THIS ARTICLE HAS BEEN RETRACTED: Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury

(2008) Koichi Obata et al.   JOURNAL OF NEUROCHEMISTRY

Differential microglial activation between acute stress and lipopolysaccharide treatment

(2008) Shuei Sugama et al.   JOURNAL OF NEUROIMMUNOLOGY

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

(2008) Yasuhiko Kawasaki et al.   NATURE MEDICINE

The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain

(2008) L. Cao et al.   NEUROSCIENCE

Activation of JNK pathway in persistent pain

(2008) Yong-Jing Gao et al.   NEUROSCIENCE LETTERS

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE

Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons

(2007) Cristian Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH