New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Excitation and Modulation of TRPA1, TRPV1, and TRPM8 Channel-expressing Sensory Neurons by the Pruritogen Chloroquine

(2013) Jonathan Y.-X. L. Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum Gastrin-Releasing Peptide Levels Correlate with Pruritus in Patients with Atopic Dermatitis

(2013) Shinji Kagami et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

(2013) Eric S. McCoy et al.   NEURON

Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis

(2013) Andrea J. Gonzales et al.   VETERINARY DERMATOLOGY

Common Neuropathic Itch Syndromes

(2012) AL Oaklander   ACTA DERMATO-VENEREOLOGICA

The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice

(2012) Y. Ohsawa et al.   ALLERGY

Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis

(2012) C.-H. Lee et al.   BRITISH JOURNAL OF DERMATOLOGY

A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus

(2012) Rajeev B. Ahuja et al.   BURNS

The Brain Circuitry Mediating Antipruritic Effects of Acupuncture

(2012) Vitaly Napadow et al.   CEREBRAL CORTEX

Central neuropathic itch as the presenting symptom of an intramedullary cavernous hemangioma: Case report and review of literature

(2012) Michele Lanotte et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Bradykinin-evoked scratching responses in complete Freund's adjuvant-inflamed skin through activation of B1 receptor

(2012) Jiexian Liang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

An aberrant parasympathetic response: a new perspective linking chronic stress and itch

(2012) Hei Sung Kim et al.   EXPERIMENTAL DERMATOLOGY

Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis

(2012) Hiroyuki Murota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Model of Touch-Evoked Itch (Alloknesis)

(2012) Tasuku Akiyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NGF Sensitizes Nociceptors for Cowhage- but Not Histamine-Induced Itch in Human Skin

(2012) Roman R. Rukwied et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling

(2012) Michael R Due et al.   Journal of Neuroinflammation

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

Endothelin-1 induces itch and pain in the mouse cheek model

(2012) Lenyta Oliveira Gomes et al.   LIFE SCIENCES

Imiquimod Enhances Excitability of Dorsal Root Ganglion Neurons by Inhibiting Background (K2P) and Voltage-Gated (Kv1.1 and Kv1.2) Potassium Channels

(2012) Jaekwang Lee et al.   Molecular Pain

The Majority of Dorsal Spinal Cord Gastrin Releasing Peptide is Synthesized Locally Whereas Neuromedin B is Highly Expressed in Pain- and Itch-Sensing Somatosensory Neurons

(2012) Michael S Fleming et al.   Molecular Pain

Galanin-Expression and Galanin-Dependent Sensory Neurons Are Not Required for Itch

(2012) Fiona E Holmes et al.   Molecular Pain

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: A prospective, crossover study

(2012) YALCIN SOLAK et al.   NEPHROLOGY

Bhlhb5 and Prdm8 Form a Repressor Complex Involved in Neuronal Circuit Assembly

(2012) Sarah E. Ross et al.   NEURON

The transient receptor potential channel TRPA1: from gene to pathophysiology

(2012) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

(2012) Tong Liu et al.   Neuroscience Bulletin

Peripheral mechanisms of itch

(2012) Benjamin McNeil et al.   Neuroscience Bulletin

Population coding of somatic sensations

(2012) Qiufu Ma   Neuroscience Bulletin

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

The Impact of Pruritus on Quality of Life

(2011) Seema P. Kini   ARCHIVES OF DERMATOLOGY

Why Does Morphine Make You Itch?

(2011) Takashi Miyamoto et al.   CELL

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

(2011) Xian-Yu Liu et al.   CELL

Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease

(2011) Sarah E Ross   CURRENT OPINION IN NEUROBIOLOGY

Mouse models of acute, chemical itch and pain in humans

(2011) Robert H. LaMotte et al.   EXPERIMENTAL DERMATOLOGY

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

(2011) Nari Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model

(2011) Tasuku Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Facial injections of pruritogens or algogens elicit distinct behavior responses in rats and excite overlapping populations of primary sensory and trigeminal subnucleus caudalis neurons

(2011) Amanda Klein et al.   JOURNAL OF NEUROPHYSIOLOGY

BAM8-22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine Release

(2011) P. Sikand et al.   JOURNAL OF NEUROSCIENCE

Glutamate Acts as a Neurotransmitter for Gastrin Releasing Peptide-Sensitive and Insensitive Itch-Related Synaptic Transmission in Mammalian Spinal Cord

(2011) Kohei Koga et al.   Molecular Pain

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice

(2011) Tsugunobu Andoh et al.   PEPTIDES

Itch Signaling in the Nervous System

(2011) Joseph Jeffry et al.   PHYSIOLOGY

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch

(2011) Kush N. Patel et al.   PLoS One

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cis-Regulatory Logic of Hedgehog Gradient Responses: Key Roles for Gli Binding Affinity, Competition, and Cooperativity

(2011) D. S. Parker et al.   Science Signaling

Pruritus: Management Algorithms and Experimental Therapies

(2011) Martin Steinhoff et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Neuropathic Itch

(2011) Anne Louise Oaklander   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Anatomy and Neurophysiology of Pruritus

(2011) Akihiko Ikoma et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Pruritus: an overview of current concepts

(2011) Martin Metz et al.   VETERINARY DERMATOLOGY

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

(2011) Simona Frateschi et al.   Nature Communications

The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice

(2010) Robson Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Generation of somatic sensory neuron diversity and implications on sensory coding

(2010) Yang Liu et al.   CURRENT OPINION IN NEUROBIOLOGY

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Labeled lines meet and talk: population coding of somatic sensations

(2010) Qiufu Ma   JOURNAL OF CLINICAL INVESTIGATION

What is this thing called pain?

(2010) Clifford J. Woolf   JOURNAL OF CLINICAL INVESTIGATION

Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors

(2010) Vemuri B. Reddy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring

(2010) MHM Ezzat et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

An Itch To Be Scratched

(2010) Kush N. Patel et al.   NEURON

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats

(2010) Earl E. Carstens et al.   NEUROREPORT

Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model

(2010) Tasuku Akiyama et al.   NEUROSCIENCE LETTERS

Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch

(2010) T. Akiyama et al.   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

The multiple pathways for itch and their interactions with pain

(2010) Steve Davidson et al.   TRENDS IN NEUROSCIENCES

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Spinal astrocyte and microglial activation contributes to rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karch

(2009) Feng Jiang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leukotriene B4 Mediates Sphingosylphosphorylcholine-Induced Itch-Associated Responses in Mouse Skin

(2009) Tsugunobu Andoh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Histological Characterization of Cutaneous Nerve Fibers Containing Gastrin-Releasing Peptide in NC/Nga Mice: An Atopic Dermatitis Model

(2009) Mitsutoshi Tominaga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cerebral Representation of the Relief of Itch by Scratching

(2009) Verena Vierow et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Superficial Dorsal Horn Neurons in the Mouse by a PAR-2 Agonist and 5-HT: Potential Role in Itch

(2009) T. Akiyama et al.   JOURNAL OF NEUROSCIENCE

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

(2009) Steve Davidson et al.   NATURE NEUROSCIENCE

Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage

(2009) Parul Sikand et al.   PAIN

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

(2009) Yong-Jing Gao et al.   PAIN

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice

(2008) R Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY

The new biology of histamine receptors

(2008) Jing-Feng Huang et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

(2008) Øystein Grimstad et al.   EXPERIMENTAL DERMATOLOGY

A Role for Polymodal C-Fiber Afferents in Nonhistaminergic Itch

(2008) L. M. Johanek et al.   JOURNAL OF NEUROSCIENCE

Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors

(2008) V. B. Reddy et al.   JOURNAL OF NEUROSCIENCE

Scratching the Brain to Understand Neuropathic Itch

(2008) Earl Carstens   JOURNAL OF PAIN

Histamine-Induced Itch and its Relationship with Pain

(2008) Won-Sik Shim et al.   Molecular Pain

Itch and pain

(2008) Martin Schmelz   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice

(2007) Dae-Kwon Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY