Spinal Circuits Transmitting Mechanical Pain and Itch

Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination

(2017) Alice Arcourt et al.   NEURON

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

(2016) Lian Cui et al.   NEURON

Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord

(2016) Matilde Cordero-Erausquin et al.   NEUROSCIENCE

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gain control mechanisms in the nociceptive system

(2016) Rolf-Detlef Treede   PAIN

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

In Vivo Interrogation of Spinal Mechanosensory Circuits

(2016) Amelia J. Christensen et al.   Cell Reports

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

(2015) Steeve Bourane et al.   CELL

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Dorsal Horn Circuits for Persistent Mechanical Pain

(2015) Cedric Peirs et al.   NEURON

Spinal excitatory mechanisms of pathological pain

(2015) Rohini Kuner   PAIN

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

(2015) S. Bourane et al.   SCIENCE

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function

(2015) Amaury François et al.   Cell Reports

Merkel Cells Transduce and Encode Tactile Stimuli to Drive Aβ-Afferent Impulses

(2014) Ryo Ikeda et al.   CELL

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Normal and abnormal coding of somatosensory stimuli causing pain

(2014) Steven A Prescott et al.   NATURE NEUROSCIENCE

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn

(2014) Rita Bardoni et al.   NEURON

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats

(2014) Danilo M. Boada et al.   PAIN

Long-term potentiation of glycinergic synapses triggered by interleukin 1 

(2014) A. M. Chirila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing K–Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model

(2013) Guillaume Lavertu et al.   BRAIN

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms

(2013) Andrea Truini et al.   Nature Reviews Neurology

Sensory neurons and circuits mediating itch

(2013) Robert H. LaMotte et al.   NATURE REVIEWS NEUROSCIENCE

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Mechanically evoked itch in humans

(2013) Miyuki Fukuoka et al.   PAIN

Constructing and deconstructing the gate theory of pain

(2013) Lorne M. Mendell   PAIN

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Mouse Model of Touch-Evoked Itch (Alloknesis)

(2012) Tasuku Akiyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

(2012) Hanns Ulrich Zeilhofer et al.   PHYSIOLOGICAL REVIEWS

Population coding of somatic sensations

(2012) Qiufu Ma   Neuroscience Bulletin

History of pain theories

(2011) Jun Chen   Neuroscience Bulletin

Labeled lines meet and talk: population coding of somatic sensations

(2010) Qiufu Ma   JOURNAL OF CLINICAL INVESTIGATION

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

Central mechanisms of pathological pain

(2010) Rohini Kuner   NATURE MEDICINE

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

(2010) Malin C. Lagerström et al.   NEURON

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

(2009) Grégory Scherrer et al.   CELL

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Innocuous, Not Noxious, Input Activates PKC  Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers

(2008) S. Neumann et al.   JOURNAL OF NEUROSCIENCE

TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat

(2008) Jeffrey J. Lawson et al.   JOURNAL OF PAIN