Revisiting Hepatitis B Virus: Challenges of Curative Therapies

Towards curative therapy of chronic viral hepatitis

(2019) Ralf Bartenschlager et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Overview of HCV Life Cycle with a Special Focus on Current and Possible Future Antiviral Targets

(2019) Nathalie Alazard-Dany et al.   Viruses-Basel

Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA

(2019) Muhammad Sheraz et al.   JOURNAL OF VIROLOGY

Comparative analysis of the antiviral effects mediated by type I and III interferons in hepatitis B virus infected hepatocytes

(2019) Jan-Hendrik Bockmann et al.   JOURNAL OF INFECTIOUS DISEASES

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

(2019) Masashi Iwamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA

(2019) Liudi Tang et al.   PLoS Pathogens

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

(2019) Dmytro Kornyeyev et al.   JOURNAL OF VIROLOGY

A global scientific strategy to cure hepatitis B

(2019) Peter A Revill et al.   Lancet Gastroenterology & Hepatology

Novel potent capsid assembly modulators regulate multiple steps of the Hepatitis B virus life-cycle

(2018) Thomas Lahlali et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

(2018) Nagraj Mani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals

(2018) Ahmed Diab et al.   ANTIVIRAL RESEARCH

Nonlytic Lymphocytes Engineered to Express Virus-Specific T-Cell Receptors Limit HBV Infection by Activating APOBEC3

(2018) Sarene Koh et al.   GASTROENTEROLOGY

The hepatitis B epidemic and the urgent need for cure preparedness

(2018) Jeffrey V. Lazarus et al.   Nature Reviews Gastroenterology & Hepatology

Role of HBx in hepatitis B virus persistence and its therapeutic implications

(2018) Betty L Slagle et al.   Current Opinion in Virology

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

(2018) Kouichi Kitamura et al.   PLoS Pathogens

Multiple roles of core protein linker in hepatitis B virus replication

(2018) Kuancheng Liu et al.   PLoS Pathogens

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

(2018) Chunkyu Ko et al.   JOURNAL OF HEPATOLOGY

N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle

(2018) Hasan Imam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development

(2018) Jianming Hu et al.   GASTROENTEROLOGY

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

(2018) Adam J. Gehring et al.   GASTROENTEROLOGY

Serum HBV RNA: a New Potential Biomarker for Chronic Hepatitis B Virus Infection

(2018) Shi Liu et al.   HEPATOLOGY

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

(2018) Julia Heger-Stevic et al.   PLoS Pathogens

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication

(2017) Ahmed Diab et al.   HEPATOLOGY

Capsid Phosphorylation State and Hepadnavirus Virion Secretion

(2017) Xiaojun Ning et al.   JOURNAL OF VIROLOGY

Identification of an Intermediate in Hepatitis B Virus Covalently Closed Circular (CCC) DNA Formation and Sensitive and Selective CCC DNA Detection

(2017) Jun Luo et al.   JOURNAL OF VIROLOGY

Correction to ‘Viral hepatitis and liver cancer’

(2017) Marc Ringelhan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Viral hepatitis and liver cancer

(2017) Marc Ringehan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nuclear Import of Hepatitis B Virus Capsids and Genome

(2017) Lara Gallucci et al.   Viruses-Basel

Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application

(2017) Jianming Hu et al.   Viruses-Basel

IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection

(2017) Yong Li et al.   Scientific Reports

The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation

(2017) Quanxin Long et al.   PLoS Pathogens

HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

(2017) Fang Guo et al.   PLoS Pathogens

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA

(2017) Yuanjie Liu et al.   PLoS Pathogens

Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

(2017) Yuchen Xia et al.   Journal of Immunology Research

Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients

(2017) Sandra Phillips et al.   Frontiers in Immunology

TGF-β triggers HBV cccDNA degradation through AID-dependent deamination

(2016) Ying Qiao et al.   FEBS LETTERS

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis

(2016) Yuchen Xia et al.   GASTROENTEROLOGY

Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors

(2016) Yong Kwang Park et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

(2016) Mohsin Khan et al.   PLoS Pathogens

DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus

(2016) Yonghe Qi et al.   PLoS Pathogens

The Epigenetic Control of Hepatitis B Virus Modulates the Outcome of Infection

(2016) Lemonica Koumbi et al.   Frontiers in Microbiology

The Structural Biology of Hepatitis B Virus: Form and Function

(2016) Balasubramanian Venkatakrishnan et al.   Annual Review of Virology

Hepatitis B virus reverse transcriptase – Target of current antiviral therapy and future drug development

(2015) Daniel N. Clark et al.   ANTIVIRAL RESEARCH

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics

(2015) Ju-Tao Guo et al.   ANTIVIRAL RESEARCH

Immune-modulators to combat hepatitis B virus infection: From IFN-α to novel investigational immunotherapeutic strategies

(2015) Nathalie Isorce et al.   ANTIVIRAL RESEARCH

Core protein: A pleiotropic keystone in the HBV lifecycle

(2015) Adam Zlotnick et al.   ANTIVIRAL RESEARCH

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Technical standards for hepatitis B virus X protein (HBx) research

(2015) Betty L. Slagle et al.   HEPATOLOGY

HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

(2015) Lise Rivière et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus Covalently Closed Circular DNA Formation in Immortalized Mouse Hepatocytes Associated with Nucleocapsid Destabilization

(2015) Xiuji Cui et al.   JOURNAL OF VIROLOGY

The Interface between Hepatitis B Virus Capsid Proteins Affects Self-Assembly, Pregenomic RNA Packaging, and Reverse Transcription

(2015) Zhenning Tan et al.   JOURNAL OF VIROLOGY

Viral DNA-Dependent Induction of Innate Immune Response to Hepatitis B Virus in Immortalized Mouse Hepatocytes

(2015) Xiuji Cui et al.   JOURNAL OF VIROLOGY

Alteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation

(2015) Xiuji Cui et al.   JOURNAL OF VIROLOGY

Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation

(2015) Philipp Tropberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular biology of hepatitis B virus infection

(2015) Christoph Seeger et al.   VIROLOGY

Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B

(2015) F. Zoulim et al.   Cold Spring Harbor Perspectives in Medicine

Hepadnavirus Genome Replication and Persistence

(2015) Jianming Hu et al.   Cold Spring Harbor Perspectives in Medicine

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

(2015) Xiuji Cui et al.   PLoS One

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome

(2015) Gianna Aurora Palumbo et al.   PLoS One

Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans

(2014) Kuancheng Liu et al.   JOURNAL OF VIROLOGY

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

(2014) Christian Königer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Targeting Hepatitis B Virus With CRISPR/Cas9

(2014) Christoph Seeger et al.   Molecular Therapy-Nucleic Acids

Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus

(2013) Sajeda Chowdhury et al.   FEBS LETTERS

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Maturation-Associated Destabilization of Hepatitis B Virus Nucleocapsid

(2013) X. Cui et al.   JOURNAL OF VIROLOGY

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription

(2013) S. Benhenda et al.   JOURNAL OF VIROLOGY

Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

(2013) Barbara Rehermann   NATURE MEDICINE

Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

(2013) Seong-Jun Kim et al.   PLoS Pathogens

Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues

(2012) Carolina Boni et al.   GASTROENTEROLOGY

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclin-Dependent Kinase 2 Phosphorylates S/T-P Sites in the Hepadnavirus Core Protein C-Terminal Domain and Is Incorporated into Viral Capsids

(2012) L. Ludgate et al.   JOURNAL OF VIROLOGY

Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

(2012) Liping Shi et al.   JOURNAL OF VIROLOGY

Protein-Primed Terminal Transferase Activity of Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase

(2012) S. A. Jones et al.   JOURNAL OF VIROLOGY

Transforming Growth Factor-β1 Suppresses Hepatitis B Virus Replication by the Reduction of Hepatocyte Nuclear Factor-4α Expression

(2012) Ming-Hsiang Hong et al.   PLoS One

Characterization of the Host Factors Required for Hepadnavirus Covalently Closed Circular (ccc) DNA Formation

(2012) Haitao Guo et al.   PLoS One

Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription

(2012) D. Cougot et al.   Science Signaling

Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication

(2012) Amanda J. Hodgson et al.   VIROLOGY

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection

(2011) Julie Lucifora et al.   JOURNAL OF HEPATOLOGY

Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice

(2011) Y. Tian et al.   JOURNAL OF VIROLOGY

Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus

(2011) T. B. Lentz et al.   JOURNAL OF VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication

(2010) D. Sir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

(2009) Marianna Hösel et al.   HEPATOLOGY

Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses

(2009) H. Guo et al.   JOURNAL OF VIROLOGY

The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

(2009) S. Asabe et al.   JOURNAL OF VIROLOGY

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Mechanism for CCC DNA Synthesis in Hepadnaviruses

(2009) Ji A. Sohn et al.   PLoS One

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A concerted action of HNF4α and HNF1α links hepatitis B virus replication to hepatocyte differentiation

(2008) Maria Quasdorff et al.   CELLULAR MICROBIOLOGY

Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells

(2008) O. Hantz et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis B Virus HBx Protein Localizes to Mitochondria in Primary Rat Hepatocytes and Modulates Mitochondrial Membrane Potential

(2008) A. J. Clippinger et al.   JOURNAL OF VIROLOGY