Journal
ANTIVIRAL RESEARCH
Volume 122, Issue -, Pages 69-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2015.08.008
Keywords
Hepatitis B virus; Interferon; Cytokines/chemokines; Immune-modulators; Immunotherapy
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Chronic hepatitis B virus (HBV) infection remains a major challenge for clinicians, as there are only two types of approved therapies: interferon-alpha (IFN-alpha) or its pegylated form, Peg-IFN-alpha and nucleoside analogs (e.g. tenofovir, entecavir...). The first are used as finite-duration treatments of around 48-52 weeks, while the second must be taken life-long to prevent rebound. Other immune-modulators, including other types of recombinant IFNs and cytokines/chemokines, could be developed for treating chronic hepatitis B. Alternatively, strategies aimed either at restoring or favoring the endogenous production of IFNs, cytokines and/or chemokines, or at alleviating HBV-mediated inhibitory processes could also be envisaged. In this article, we review current investigational, preclinical and clinical efforts to implement immune-modulatory components in the therapy of chronic hepatitis B. This review forms part of a symposium in Antiviral Research on An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B. (C) 2015 Elsevier B.V. All rights reserved.
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