Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions

(2017) Rohit Loomba et al.   GASTROENTEROLOGY

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo

(2017) Lena Allweiss et al.   GUT

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation

(2017) Wen Zhang et al.   HEPATOLOGY

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

(2017) Mark A. Dawson   SCIENCE

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators

(2016) Dawei Cai et al.   ANTIVIRAL RESEARCH

Combining Epigenetic and Immunotherapy to Combat Cancer

(2016) Katherine B. Chiappinelli et al.   CANCER RESEARCH

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis

(2016) Yuchen Xia et al.   GASTROENTEROLOGY

Hepatitis B virus X protein crosses out Smc5/6 complex to maintain covalently closed circular DNA transcription

(2016) Bidisha Mitra et al.   HEPATOLOGY

New therapies for chronic hepatitis B

(2016) Maya Bitton Alaluf et al.   LIVER INTERNATIONAL

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Histone H3 globular domain acetylation identifies a new class of enhancers

(2016) Madapura M Pradeepa et al.   NATURE GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

(2016) Christopher M. Murphy et al.   Cell Reports

Present and future therapies of hepatitis B: From discovery to cure

(2015) T. Jake Liang et al.   HEPATOLOGY

HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase

(2015) Lise Rivière et al.   JOURNAL OF HEPATOLOGY

Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013

(2015) Aparna Schweitzer et al.   LANCET

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation

(2015) Philipp Tropberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular biology of hepatitis B virus infection

(2015) Christoph Seeger et al.   VIROLOGY

Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication

(2015) L Zhong et al.   Cell Death & Disease

Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues

(2015) Surbhi Jain et al.   Scientific Reports

Epigenetic control of HIV-1 post integration latency: implications for therapy

(2015) Amit Kumar et al.   Clinical Epigenetics

Targeting Epigenetic Processes in Photodynamic Therapy-Induced Anticancer Immunity

(2015) Malgorzata Wachowska et al.   Frontiers in Oncology

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

(2015) Huili Li et al.   Oncotarget

(−)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes

(2014) Hsiu-Chen Huang et al.   ANTIVIRAL RESEARCH

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

(2014) Yongmei Zhang et al.   PLoS One

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Chronic hepatitis B: What should be the goal for new therapies?

(2013) Timothy M. Block et al.   ANTIVIRAL RESEARCH

Regulation of Transcription through Acetylation of H3K122 on the Lateral Surface of the Histone Octamer

(2013) Philipp Tropberger et al.   CELL

5-Azacytidine for the treatment of myelodysplastic syndromes

(2013) Janusz Krawczyk et al.   EXPERT OPINION ON PHARMACOTHERAPY

T-cell memory differentiation: insights from transcriptional signatures and epigenetics

(2013) Ben Youngblood et al.   IMMUNOLOGY

Methyltransferase PRMT1 Is a Binding Partner of HBx and a Negative Regulator of Hepatitis B Virus Transcription

(2013) S. Benhenda et al.   JOURNAL OF VIROLOGY

Comparative Analysis of CpG Islands among HBV Genotypes

(2013) Yongmei Zhang et al.   PLoS One

Epigenetic effects of green tea polyphenols in cancer

(2013) Susanne M Henning et al.   Epigenomics

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

(2013) Fei Liu et al.   PLoS Pathogens

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome

(2012) Laura Belloni et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

(2012) Liping Shi et al.   JOURNAL OF VIROLOGY

Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis

(2012) H.-C. Huang et al.   JOURNAL OF VIROLOGY

Shock and kill

(2012) Steven G. Deeks   NATURE

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

(2011) M. Ananthanarayanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma

(2011) D. Buglio et al.   BLOOD

Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents

(2011) S. K. Ghosh et al.   BLOOD

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice

(2010) Marc Lutgehetmann et al.   HEPATOLOGY

Hepatitis B Virus Replication Induces Methylation of both Host and Viral DNA

(2010) P. Vivekanandan et al.   JOURNAL OF VIROLOGY

Pathogenesis of hepatitis B virus infection

(2010) F.V. Chisari et al.   PATHOLOGIE BIOLOGIE

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines

(2008) D. Buglio et al.   BLOOD

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

(2008) Da-Li Zheng et al.   JOURNAL OF HEPATOLOGY

Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors

(2007) Giovanna Fattovich et al.   JOURNAL OF HEPATOLOGY