The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation

Epigenetic regulation of hepatitis B virus covalently closed circular DNA: Implications for epigenetic therapy against chronic hepatitis B

(2017) Xupeng Hong et al.   HEPATOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-term hepatitis B infection in a scalable hepatic co-culture system

(2017) Benjamin Y. Winer et al.   Nature Communications

Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators

(2016) Dawei Cai et al.   ANTIVIRAL RESEARCH

Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA

(2016) Chunlan Liu et al.   ANTIVIRAL RESEARCH

DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus

(2016) Yonghe Qi et al.   PLoS Pathogens

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics

(2015) Ju-Tao Guo et al.   ANTIVIRAL RESEARCH

The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion

(2015) Ran Yan et al.   JOURNAL OF VIROLOGY

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems

(2015) Tetsushi Sakuma et al.   Nature Protocols

Spinoculation Enhances HBV Infection in NTCP-Reconstituted Hepatocytes

(2015) Ran Yan et al.   PLoS One

Molecular biology of hepatitis B virus infection

(2015) Christoph Seeger et al.   VIROLOGY

Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B

(2015) F. Zoulim et al.   Cold Spring Harbor Perspectives in Medicine

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

(2015) Xiuji Cui et al.   PLoS One

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

(2014) John G Doench et al.   NATURE BIOTECHNOLOGY

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

(2014) Christian Königer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic hepatitis B: What should be the goal for new therapies?

(2013) Timothy M. Block et al.   ANTIVIRAL RESEARCH

Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation

(2012) Dawei Cai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells

(2012) Catherine Le Chalony et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effectiveness of Hepatitis B Treatment in Clinical Practice

(2012) Steven J. Scaglione et al.   GASTROENTEROLOGY

Characterization of the Host Factors Required for Hepadnavirus Covalently Closed Circular (ccc) DNA Formation

(2012) Haitao Guo et al.   PLoS One

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells

(2011) Hiroshi Arakawa et al.   NUCLEIC ACIDS RESEARCH

Hepatitis B: The virus and disease

(2010) T. Jake Liang   HEPATOLOGY

Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner

(2010) Josef Köck et al.   PLoS Pathogens

Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses

(2009) H. Guo et al.   JOURNAL OF VIROLOGY

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

(2008) Shijun Zhong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH