Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
Authors
Keywords
-
Journal
NATURE MEDICINE
Volume 19, Issue 7, Pages 859-868
Publisher
Springer Nature
Online
2013-07-09
DOI
10.1038/nm.3251
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
- (2013) Ludmila Prokunina-Olsson et al. NATURE GENETICS
- Future therapies for chronic hepatitis C
- (2013) Noura M. Dabbouseh et al. Nature Reviews Gastroenterology & Hepatology
- Combined Blockade of Programmed Death-1 and Activation of CD137 Increase Responses of Human Liver T Cells Against HBV, But Not HCV
- (2012) Paola Fisicaro et al. GASTROENTEROLOGY
- Hepatic Cell–Type Specific Gene Expression Better Predicts HCV Treatment Outcome Than IL28B Genotype
- (2012) Ian McGilvray et al. GASTROENTEROLOGY
- Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues
- (2012) Carolina Boni et al. GASTROENTEROLOGY
- Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients With HCV Genotype 1 Infection
- (2012) Daryl T.–Y. Lau et al. GASTROENTEROLOGY
- Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection
- (2012) Stefania Varchetta et al. HEPATOLOGY
- Natural killer p46Highexpression defines a natural killer cell subset that is potentially involved in control of hepatitis C virus replication and modulation of liver fibrosis
- (2012) Benjamin Krämer et al. HEPATOLOGY
- Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells
- (2012) Hans-Peter Raué et al. IMMUNITY
- Intrahepatic Expression of Programmed Death-1 and its Ligands in Patients with HBV-Related Acute-on-Chronic Liver Failure
- (2012) Dayan Cao et al. INFLAMMATION
- Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion
- (2012) Dimitra Peppa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection
- (2012) A. Das et al. JOURNAL OF IMMUNOLOGY
- The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection
- (2012) K. D. Cook et al. JOURNAL OF IMMUNOLOGY
- Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation
- (2012) J. R. Larrubia et al. JOURNAL OF VIRAL HEPATITIS
- NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner
- (2012) Andreas Glässner et al. LABORATORY INVESTIGATION
- Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity
- (2012) Sebastian Zeissig et al. NATURE MEDICINE
- NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections
- (2012) Raymond M. Welsh et al. VIROLOGY
- Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C
- (2012) Phyllis T. Losikoff et al. Virulence
- Activating NK cell receptor expression/function (NKp30, NKp46, DNAM-1) during chronic viraemic HCV infection is associated with the outcome of combined treatment
- (2011) Federica Bozzano et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Early Changes in Natural Killer Cell Function Indicate Virologic Response to Interferon Therapy for Hepatitis C
- (2011) Golo Ahlenstiel et al. GASTROENTEROLOGY
- Delayed Induction, Not Impaired Recruitment, of Specific CD8+ T Cells Causes the Late Onset of Acute Hepatitis C
- (2011) Eui–Cheol Shin et al. GASTROENTEROLOGY
- Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
- (2011) K. Fitzmaurice et al. GUT
- NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
- (2011) Chamutal Gur et al. GUT
- Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations
- (2011) Christoph Neumann-Haefelin et al. HEPATOLOGY
- Early changes in interferon signaling define natural killer cell response and refractoriness to interferon-based therapy of hepatitis C patients
- (2011) Birgit Edlich et al. HEPATOLOGY
- Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C
- (2011) Lucy Golden-Mason et al. HEPATOLOGY
- Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
- (2011) Anna Schurich et al. HEPATOLOGY
- IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B
- (2011) Jean Publicover et al. JOURNAL OF CLINICAL INVESTIGATION
- Transmission of Clonal Hepatitis C Virus Genomes Reveals the Dominant but Transitory Role of CD8+ T Cells in Early Viral Evolution
- (2011) B. Callendret et al. JOURNAL OF VIROLOGY
- Cell-to-Cell Contact with Hepatitis C Virus-Infected Cells Reduces Functional Capacity of Natural Killer Cells
- (2011) J. C. Yoon et al. JOURNAL OF VIROLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection
- (2011) R. D. Aubert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
- (2011) P. A. Lang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation of HCV-Specific CD8+ T Cells
- (2011) Verena Schlaphoff et al. PLoS Pathogens
- Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes
- (2010) Arthur Y. Kim et al. GASTROENTEROLOGY
- The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function
- (2010) Bijan Raziorrouh et al. HEPATOLOGY
- Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
- (2010) Rachel H. McMahan et al. JOURNAL OF CLINICAL INVESTIGATION
- Absence of mouse 2B4 promotes NK cell–mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis
- (2010) Stephen N. Waggoner et al. JOURNAL OF CLINICAL INVESTIGATION
- Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV
- (2010) Armanda Casrouge et al. JOURNAL OF CLINICAL INVESTIGATION
- A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B
- (2010) Anthony T. Tan et al. JOURNAL OF HEPATOLOGY
- Altered interferon-α-signaling in natural killer cells from patients with chronic hepatitis C virus infection
- (2010) Takuya Miyagi et al. JOURNAL OF HEPATOLOGY
- Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B
- (2010) Eric T.T.L. Tjwa et al. JOURNAL OF HEPATOLOGY
- Transient CD86 Expression on Hepatitis C Virus-Specific CD8 + T Cells in Acute Infection Is Linked to Sufficient IL-2 Signaling
- (2010) Henry Radziewicz et al. JOURNAL OF IMMUNOLOGY
- Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses
- (2010) Silke Paust et al. NATURE IMMUNOLOGY
- Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery
- (2010) S. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection
- (2010) K. Takahashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation
- (2010) Bertram Bengsch et al. PLoS Pathogens
- Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection
- (2010) Dimitra Peppa et al. PLoS Pathogens
- Hepatitis C Virus (HCV) Evades NKG2D-Dependent NK Cell Responses through NS5A-Mediated Imbalance of Inflammatory Cytokines
- (2010) Damien Sène et al. PLoS Pathogens
- Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection
- (2009) Claire Dunn et al. GASTROENTEROLOGY
- Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections
- (2009) Barbara Oliviero et al. GASTROENTEROLOGY
- Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa–Dependent Manner
- (2009) Golo Ahlenstiel et al. GASTROENTEROLOGY
- Early kinetics of innate and adaptive immune responses during hepatitis B virus infection
- (2009) P Fisicaro et al. GUT
- Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection
- (2009) Michael J. Fuller et al. HEPATOLOGY
- Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
- (2009) Barbara Rehermann JOURNAL OF CLINICAL INVESTIGATION
- Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C
- (2009) Paula Bonorino et al. JOURNAL OF HEPATOLOGY
- Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection
- (2009) Stefania Crotta et al. JOURNAL OF HEPATOLOGY
- Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion
- (2009) C. M. Bucks et al. JOURNAL OF IMMUNOLOGY
- Peripheral CXCR3‐Associated Chemokines as Biomarkers of Fibrosis in Chronic Hepatitis C Virus Infection
- (2009) Marija Zeremski et al. JOURNAL OF INFECTIOUS DISEASES
- The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection
- (2009) S. Asabe et al. JOURNAL OF VIROLOGY
- Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections
- (2009) A. R. Stacey et al. JOURNAL OF VIROLOGY
- Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
- (2009) L. Golden-Mason et al. JOURNAL OF VIROLOGY
- Hepatitis B virus infection
- (2009) Yun-Fan Liaw et al. LANCET
- Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
- (2009) Dongliang Ge et al. NATURE
- Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
- (2009) David L. Thomas et al. NATURE
- IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
- (2009) Vijayaprakash Suppiah et al. NATURE GENETICS
- Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
- (2009) Yasuhito Tanaka et al. NATURE GENETICS
- High antigen levels are the cause of T cell exhaustion during chronic viral infection
- (2009) S. N. Mueller et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
- (2009) Nobuhiro Nakamoto et al. PLoS Pathogens
- Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization
- (2008) Nobuhiro Nakamoto et al. GASTROENTEROLOGY
- Analysis of CD8+ T-Cell–Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model
- (2008) Juandy Jo et al. GASTROENTEROLOGY
- Natural killer cell function is intact after direct exposure to infectious hepatitis C virions
- (2008) Joo Chun Yoon et al. HEPATOLOGY
- Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C
- (2008) Marija Zeremski et al. HEPATOLOGY
- Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection
- (2008) A. Ross Lopes et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
- (2008) Abhishek Das et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TLR-dependent cross talk between human Kupffer cells and NK cells
- (2008) Zhengkun Tu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
- (2008) Shawn D Blackburn et al. NATURE IMMUNOLOGY
- Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
- (2008) Scott L. Friedman PHYSIOLOGICAL REVIEWS
- Interferon signaling and treatment outcome in chronic hepatitis C
- (2008) M. Sarasin-Filipowicz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lymphocyte recruitment to the liver: Molecular insights into the pathogenesis of liver injury and hepatitis
- (2008) Shishir Shetty et al. TOXICOLOGY
- Starring stellate cells in liver immunology
- (2007) Florian Winau et al. CURRENT OPINION IN IMMUNOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started