Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model

(2019) Hee-Yun Kim et al.   INFLAMMATION RESEARCH

Pharmacokinetic comparisons of major bioactive components after oral administration of raw and steamed rhubarb by UPLC-MS/MS

(2019) Jing Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cytochrome P450 mediated metabolic activation of chrysophanol

(2018) Ying Sun et al.   CHEMICO-BIOLOGICAL INTERACTIONS

OUP accepted manuscript

(2018)   EUROPEAN HEART JOURNAL

Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice

(2018) Yongmei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bioassay-guided purification of α-amylase, α-glucosidase inhibitors and DPPH radical scavengers from roots of Rheum turkestanicum

(2018) Hossein Dehghan et al.   INDUSTRIAL CROPS AND PRODUCTS

Regulatory effects of chrysophanol, a bioactive compound of AST2017-01 in a mouse model of 2,4-dinitrofluorobenzene-induced atopic dermatitis

(2018) Na-Ra Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chrysophanol demonstrates anti-inflammatory properties in LPS-primed RAW 264.7 macrophages through activating PPAR-γ

(2018) Quan Wen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models

(2018) Hyun-Ja Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Asphodeline lutea Compounds on Toxicity Models in Isolated Rat Microsomes and Hepatocytes

(2018) Magdalena Kondeva-Burdina et al.   Letters in Drug Design & Discovery

Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062

(2018) Suradet Buttachon et al.   Marine Drugs

Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice

(2018) Xu Chu et al.   NEUROCHEMICAL RESEARCH

Selected anthraquinones as potential free radical scavengers and P-glycoprotein inhibitors

(2018) S. Jeremić et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aurantio-obtusin, an anthraquinone from cassiae semen, ameliorates lung inflammatory responses

(2018) Ki Sun Kwon et al.   PHYTOTHERAPY RESEARCH

Near-infrared spectroscopy for rapid and simultaneous determination of five main active components in rhubarb of different geographical origins and processing

(2018) Xue Jintao et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Chrysophanol induces cell death and inhibits invasiveness via mitochondrial calcium overload in ovarian cancer cells

(2018) Whasun Lim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

On-line incubation and real-time detection by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapidly analyzing metabolites of anthraquinones in rat liver microsomes

(2018) Yang Xu et al.   JOURNAL OF CHROMATOGRAPHY A

Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion

(2018) Yongmei Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

Metabolism and mutual biotransformations of anthraquinones and anthrones in rhubarb by human intestinal flora using UPLC-Q-TOF/MS

(2018) Zhenghai Huang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity

(2018) Pauline Mury et al.   SPORTS MEDICINE

Chrysophanol selectively represses breast cancer cell growth by inducing reactive oxygen species production and endoplasmic reticulum stress via AKT and mitogen-activated protein kinase signal pathways

(2018) Sunwoo Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fission

(2017) Unbin Chae et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Affinity chromatographic methodologies based on immobilized voltage dependent anion channel isoform 1 and application in protein-ligand interaction analysis and bioactive compounds screening from traditional medicine

(2017) Qian Li et al.   JOURNAL OF CHROMATOGRAPHY A

Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission

(2017) Unbin Chae et al.   PHARMACOLOGY

Phytochemical investigation of Aloe pulcherrima roots and evaluation for its antibacterial and antiplasmodial activities

(2017) Dele Abdissa et al.   PLoS One

Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes

(2017) Li Kang et al.   TOXICOLOGY IN VITRO

The effects of chrysophanol on ovalbumin (OVA)-induced chronic lung toxicology by inhibiting Th17 response

(2017) Chunyan Zhang et al.   TOXICOLOGY MECHANISMS AND METHODS

The effects of chrysophanol on ovalbumin (OVA)-induced chronic lung toxicology by inhibiting Th17 response

(2017) Chunyan Zhang et al.   TOXICOLOGY MECHANISMS AND METHODS

Analysis of Metabolites of Anthraquinones by Human Fecal Bacteria Using UPLC-Q-TOF-HRMS/MS

(2016) Min Fan et al.   CHROMATOGRAPHIA

Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis

(2016) Yuting Cui et al.   FOOD AND CHEMICAL TOXICOLOGY

Activating Peroxisome Proliferator-Activated Receptors (PPARs): a New Sight for Chrysophanol to Treat Paraquat-Induced Lung Injury

(2016) Ang Li et al.   INFLAMMATION

Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways

(2016) Whasun Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan

(2016) Toshihisa Onoda et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-giardia activity and acute toxicity of a methanol extract of Senna racemosa bark

(2016) Edgar E. Caamal-Fuentes et al.   JOURNAL OF ETHNOPHARMACOLOGY

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

(2016) Shimo Kang et al.   JOURNAL OF FOOD PROCESSING AND PRESERVATION

The pharmacokinetic screening of multiple components of the Nao Mai Tong formula in rat plasma by liquid chromatography tandem mass spectrometry combined with pattern recognition method and its application to comparative pharmacokinetics

(2016) Chunwei Wu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

(2016) Kai Zhang et al.   NEUROSCIENCE LETTERS

Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice

(2016) Yongmei Zhao et al.   NEUROSCIENCE LETTERS

Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase

(2016) Dong-Hyun Youn et al.   Oncotarget

Protective effect of chrysophanol on LPS/d-GalN-induced hepatic injury through the RIP140/NF-κB pathway

(2016) Wenjiao Jiang et al.   RSC Advances

Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro

(2016) Hara Lim et al.   Frontiers in Pharmacology

Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones

(2015) Liping Ma et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Activity-Guided Chemo Toxic Profiling of Cassia occidentalis (CO) Seeds: Detection of Toxic Compounds in Body Fluids of CO-Exposed Patients and Experimental Rats

(2015) Gati Krushna Panigrahi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Powdered Shells of the SnailMegalobulimus lopesion Secondary-Intention Wound Healing in an Animal Model

(2015) Paulo Henrique Muleta Andrade et al.   Evidence-based Complementary and Alternative Medicine

In vitro anti-Neisseria gonorrhoeae activity of Senna podocarpa root extracts

(2015) Maryam Malmir et al.   INDUSTRIAL CROPS AND PRODUCTS

Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction

(2015) Xiao Liu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels

(2015) Lei-Chi Dong et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Influence ofAconitum carmichaeliiDebx. on the Pharmacokinetic Characteristics of Main Components inRheum palmatumL.

(2015) Yun-xia Li et al.   PHYTOTHERAPY RESEARCH

Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi

(2015) Aditya Arvindekar et al.   Food & Function

Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus

(2014) Shu-Jen Chang et al.   ARCHIVES OF PHARMACAL RESEARCH

Leaching and Kinetic Modeling of Pyrite Cinder in Sulphuric Acid

(2014) Z.Z. Shi et al.   ASIAN JOURNAL OF CHEMISTRY

A novel GC–MS method for determination of chrysophanol in rat plasma and tissues: Application to the pharmacokinetics, tissue distribution and plasma protein binding studies

(2014) Qinhua Chen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Comparative pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules in normal and acute blood stasis rabbits

(2014) Xiao-yan Dai et al.   JOURNAL OF ETHNOPHARMACOLOGY

1H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia–reperfusion rats

(2014) Qinxiao Guan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice

(2014) Shu Wang et al.   Neural Regeneration Research

Evaluation of anthraquinones from Himalayan rhubarb (Rheum emodi Wall. ex Meissn.) as antiproliferative agents

(2014) Shahzad A. Pandith et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract

(2013) Wenjin Wu et al.   BIOMEDICAL CHROMATOGRAPHY

Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

(2013) Yan Wang et al.   Evidence-based Complementary and Alternative Medicine

Application of frontal affinity chromatography combined on-line with mass spectrometry to screening PAI-1 inhibitors from traditional Chinese medicine

(2012) Xiaohong Yuan et al.   Analytical Methods

Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells

(2012) Yao Yao et al.   APOPTOSIS

Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells

(2012) Chien-Hang Ni et al.   ARCHIVES OF PHARMACAL RESEARCH

Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition

(2012) Woo-Jung Lee et al.   BMB Reports

A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector

(2012) Yang Wang et al.   Chinese Journal of Integrative Medicine

Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential

(2012) Chien-Hang Ni et al.   ENVIRONMENTAL TOXICOLOGY

Two Novel Naphthalene Glucosides and an Anthraquinone Isolated from Rumex dentatus and Their Antiproliferation Activities in Four Cell Lines

(2012) Hui Zhang et al.   MOLECULES

Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats

(2011) Chi-Sheng Shia et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatography-tandem mass spectrometry

(2010) Rui Song et al.   BIOMEDICAL CHROMATOGRAPHY

Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells

(2010) Chi-Cheng Lu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-kB/Caspase-1 Activation in Vitro and in Vivo

(2010) Su-Jin Kim et al.   MOLECULES

Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway

(2010) Myung Sun Lee et al.   PHYTOTHERAPY RESEARCH

Anti-diabetic Properties of Chrysophanol and Its Glucoside from Rhubarb Rhizome

(2008) Myung Sun Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE