Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells

Antioxidant Enzymatic Activities in Alzheimer's Disease: The Relationship to Acetylcholinesterase Inhibitors

(2018) Anthony Klugman et al.   JOURNAL OF ALZHEIMERS DISEASE

Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

(2017) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells

(2013) Li-Long Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors

(2013) Da-Hua Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Shikonin Protects Dopaminergic Cell Line PC12 Against 6-Hydroxydopamine-Mediated Neurotoxicity Via Both Glutathione-Dependent and Independent Pathways and by Inhibiting Apoptosis

(2013) Emran Esmaeilzadeh et al.   NEUROCHEMICAL RESEARCH

Baicalein protects Human melanocytes from H2O2-induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway

(2012) Bangmin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lithospermum erythrorhizon Suppresses High-Fat Diet-Induced Obesity, and Acetylshikonin, a Main Compound of Lithospermum erythrorhizon, Inhibits Adipocyte Differentiation

(2012) So Young Gwon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury

(2012) Feng Zhang et al.   STROKE

Drug-like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase

(2011) Scott A. Wildman et al.   Chemical Biology & Drug Design

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation

(2011) J. Egea et al.   NEUROPHARMACOLOGY

High-level expression of functional recombinant human butyrylcholinesterase in silkworm larvae by Bac-to-Bac system

(2010) Shuo Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis

(2010) Kelvin Kin-Kwan Wong et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors

(2010) Zaheer-ul-Haq et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer’s disease

(2010) Jocley Queiroz Araújo et al.   JOURNAL OF MOLECULAR MODELING

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of Orphan Nuclear Receptor Nur77-Mediated Apoptotic Pathway by Acetylshikonin and Analogues

(2008) Jie Liu et al.   CANCER RESEARCH

Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors

(2008) Ping Jia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-κB: neuroprotective implications

(2008) Kyong Nyon Nam et al.   NEUROPHARMACOLOGY