Herpes simplex virus type 1 and Alzheimer’s disease: link and potential impact on treatment

Herpes Simplex Virus, APOE ɛ4, and Cognitive Decline in Old Age: Results from the Betula Cohort Study

(2019) Hugo Lövheim et al.   JOURNAL OF ALZHEIMERS DISEASE

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

(2019) Giovanna De Chiara et al.   PLoS Pathogens

Herpes Simplex Virus Evasion of Early Host Antiviral Responses

(2019) Eduardo I. Tognarelli et al.   Frontiers in Cellular and Infection Microbiology

Cyanidin-3- O -glucoside ameliorates diabetic nephropathy through regulation of glutathione pool

(2018) Yan Qin et al.   BIOMEDICINE & PHARMACOTHERAPY

HSV-1-Specific IgG Subclasses Distribution and Serum Neutralizing Activity in Alzheimer’s Disease and in Mild Cognitive Impairment

(2018) Simone Agostini et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes Zoster and Dementia

(2018) Vincent Chin-Hung Chen et al.   JOURNAL OF CLINICAL PSYCHIATRY

Epigallocatechin Gallate Reduces Amyloid β-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis

(2018) Ke Du et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data

(2018) Ghulam Hussain et al.   MOLECULES

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus

(2018) Ben Readhead et al.   NEURON

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Palmitoylethanolamide Dampens Reactive Astrogliosis and Improves Neuronal Trophic Support in a Triple Transgenic Model of Alzheimer’s Disease: In Vitro and In Vivo Evidence

(2018) Maria Rosanna Bronzuoli et al.   Oxidative Medicine and Cellular Longevity

Infection and Transport of Herpes Simplex Virus Type 1 in Neurons: Role of the Cytoskeleton

(2018) Monica Miranda-Saksena et al.   Viruses-Basel

Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer’s Disease

(2018) Ruth Alonso et al.   Frontiers in Aging Neuroscience

Aging-Related Neurostructural, Neuropathological, and Behavioral Changes Associated with Herpes Simplex Virus Type 1 Brain Infection in Mice

(2018) Fernando Guzman-Sanchez et al.   JOURNAL OF ALZHEIMERS DISEASE

Herpes Simplex Virus Type I Induces an Incomplete Autophagic Response in Human Neuroblastoma Cells

(2018) Soraya Santana et al.   JOURNAL OF ALZHEIMERS DISEASE

Titers of Herpes Simplex Virus Type 1 Antibodies Positively Correlate with Grey Matter Volumes in Alzheimer's Disease

(2018) Roberta Mancuso et al.   JOURNAL OF ALZHEIMERS DISEASE

A Complex Proinflammatory Role for Peripheral Monocytes in Alzheimer's Disease

(2018) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory and Neurodegeneration Markers during Asymptomatic HSV-1 Reactivation

(2018) Carolina Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of the AMPK/Sirt1 Axis During Neuronal Infection by Herpes Simplex Virus Type 1

(2018) Carolina Martin et al.   JOURNAL OF ALZHEIMERS DISEASE

CD8+ Resident Memory T Cells and Viral Infection

(2018) Xuejie Wu et al.   Frontiers in Immunology

Critical Role of Regulatory T Cells in the Latency and Stress-Induced Reactivation of HSV-1

(2018) Wencong Yu et al.   Cell Reports

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

(2018) Nisha Rathore et al.   PLoS Genetics

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

Hypophosphatemia predicts a failure to recover from adefovir-related renal injury after dose reduction in lamivudine-resistant hepatitis B patients

(2017) Tatsuo Yamamoto et al.   HEPATOLOGY RESEARCH

Modulation of Immune Responses to Herpes Simplex Virus Type 1 by IFNL3 and IRF7 Polymorphisms: A Study in Alzheimer’s Disease

(2017) Andrea Saul Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis

(2017) Katherine D. Shives et al.   JOURNAL OF NEUROIMMUNOLOGY

Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection

(2017) Jie Zhang et al.   Journal of Zhejiang University-SCIENCE B

The suppression of apoptosis by α-herpesvirus

(2017) Yu You et al.   Cell Death & Disease

Complement Evasion Strategies of Viruses: An Overview

(2017) Palak Agrawal et al.   Frontiers in Microbiology

Herpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within

(2017) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased risk of dementia following herpes zoster ophthalmicus

(2017) Ming-Chieh Tsai et al.   PLoS One

Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies

(2016) Roberto Sansone et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress

(2016) Hamid Sohanaki et al.   BIOMEDICINE & PHARMACOTHERAPY

High avidity HSV-1 antibodies correlate with absence of amnestic Mild Cognitive Impairment conversion to Alzheimer’s disease

(2016) Simone Agostini et al.   BRAIN BEHAVIOR AND IMMUNITY

HSV presence in brains of individuals without dementia: the TASTY brain series

(2016) Jan Olsson et al.   Disease Models & Mechanisms

A protective role for herpes simplex virus type-1-specific humoral immunity in Alzheimer’s Disease

(2016) Simone Agostini et al.   Expert Review of Anti-Infective Therapy

Anti-Viral Properties of Amyloid-β Peptides

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses

(2016) Lichen Jing et al.   JOURNAL OF IMMUNOLOGY

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

(2016) HUIMIN WANG et al.   Molecular Medicine Reports

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help

(2016) Norifumi Iijima et al.   NATURE

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology

(2016) Stephen W. Scheff et al.   NEUROBIOLOGY OF AGING

Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells

(2016) Sarinthorn Thummayot et al.   NEUROCHEMISTRY INTERNATIONAL

Status of vaccine research and development of vaccines for herpes simplex virus

(2016) Christine Johnston et al.   VACCINE

Evasion of host antiviral innate immunity by HSV-1, an update

(2016) Chenhe Su et al.   Virology Journal

The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways

(2016) Xiaoliang Yu et al.   Virology Journal

A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex

(2016) Valentina Herbring et al.   Scientific Reports

Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome

(2016) Gabriella Campadelli-Fiume et al.   Annual Review of Virology

Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia

(2015) G. Andrei et al.   ANTIVIRAL RESEARCH

The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome

(2015) Benedict Daniel Michael et al.   JOURNAL OF INFECTIOUS DISEASES

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT)

(2015) Dale Carpenter et al.   JOURNAL OF NEUROVIROLOGY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

(2015) Angélica Maria Sabogal-Guáqueta et al.   NEUROPHARMACOLOGY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012

(2015) Katharine J. Looker et al.   PLoS One

Xenophagy in herpes simplex virus replication and pathogenesis

(2014) Diane Alexander et al.   Autophagy

Role of Herpes Simplex Virus 1 Immediate Early Protein ICP22 in Viral Nuclear Egress

(2014) Y. Maruzuru et al.   JOURNAL OF VIROLOGY

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer’s disease

(2014) C Scuderi et al.   Cell Death & Disease

Relationship between herpes simplex virus-1-specific antibody titers and cortical brain damage in Alzheimer’s disease and amnestic mild cognitive impairment

(2014) Roberta Mancuso et al.   Frontiers in Aging Neuroscience

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

(2014) Karen E. Johnson et al.   PLoS Pathogens

Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature

(2014) Richard Lathe et al.   BMC Geriatrics

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges

(2014) Jeffrey L Cummings et al.   Expert Review of Clinical Pharmacology

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

An Inquiry into the Molecular Basis of HSV Latency and Reactivation

(2013) Bernard Roizman et al.   Annual Review of Microbiology

Virus Infections in the Nervous System

(2013) Orkide O. Koyuncu et al.   Cell Host & Microbe

Asymptomatic HLA-A*02:01-Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes

(2013) X. Dervillez et al.   JOURNAL OF IMMUNOLOGY

Recognition of Herpes Simplex Viruses: Toll-Like Receptors and Beyond

(2013) Yijie Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Herpes virus in Alzheimer's disease: relation to progression of the disease

(2013) Ilaria Carbone et al.   NEUROBIOLOGY OF AGING

Us3 Kinase Encoded by Herpes Simplex Virus 1 Mediates Downregulation of Cell Surface Major Histocompatibility Complex Class I and Evasion of CD8+ T Cells

(2013) Takahiko Imai et al.   PLoS One

Oxidative Stress Enhances Neurodegeneration Markers Induced by Herpes Simplex Virus Type 1 Infection in Human Neuroblastoma Cells

(2013) Soraya Santana et al.   PLoS One

Effects of Food and Drug Administration-approved medications for Alzheimer’s disease on clinical progression

(2012) Michelle M. Mielke et al.   Alzheimers & Dementia

Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer’s disease

(2012) Nobuyuki Kobayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons

(2012) Tal Kramer et al.   Cell Host & Microbe

Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol

(2012) Su-Yang Liu et al.   IMMUNITY

Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

(2012) Raymond P. Stowe et al.   JOURNAL OF MEDICAL VIROLOGY

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells

(2012) Gema Álvarez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Discovery of Potential Diagnostic and Vaccine Antigens in Herpes Simplex Virus 1 and 2 by Proteome-Wide Antibody Profiling

(2012) Mina Kalantari-Dehaghi et al.   JOURNAL OF VIROLOGY

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The many roles of the highly interactive HSV protein ICP27, a key regulator of infection

(2011) Rozanne M Sandri-Goldin   Future Microbiology

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues

(2011) Bernard Roizman et al.   JOURNAL OF NEUROVIROLOGY

CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation

(2011) Anthony J. St. Leger et al.   JOURNAL OF NEUROVIROLOGY

Herpes Simplex Virus 1 Glycoprotein B and US3 Collaborate To Inhibit CD1d Antigen Presentation and NKT Cell Function

(2011) P. Rao et al.   JOURNAL OF VIROLOGY

Uncoupling Uncoating of Herpes Simplex Virus Genomes from Their Nuclear Import and Gene Expression

(2011) K. Rode et al.   JOURNAL OF VIROLOGY

Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization

(2011) Sudhakar Veeranki et al.   MOLECULAR IMMUNOLOGY

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

(2011) Jean-Charles Lambert et al.   NEUROBIOLOGY OF AGING

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

(2011) Soraya Santana et al.   NEUROBIOLOGY OF AGING

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Alzheimer's disease gene signature says: beware of brain viral infections

(2011) Elisa Porcellini et al.   Immunity & Ageing

Epigenetic regulation of latent HSV-1 gene expression

(2010) David C. Bloom et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Detailed Characterization of T Cell Responses to Herpes Simplex Virus-2 in Immune Seronegative Persons

(2010) C. M. Posavad et al.   JOURNAL OF IMMUNOLOGY

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

(2010) Roberto Piacentini et al.   NEUROBIOLOGY OF AGING

Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis

(2010) A Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Herpes Simplex Virus Utilizes the Large Secretory Vesicle Pathway for Anterograde Transport of Tegument and Envelope Proteins and for Viral Exocytosis from Growth Cones of Human Fetal Axons

(2009) M. Miranda-Saksena et al.   JOURNAL OF VIROLOGY

Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit Apoptosis

(2009) W. Shen et al.   JOURNAL OF VIROLOGY

Functional roles of the tegument proteins of herpes simplex virus type 1

(2009) Barbara J. Kelly et al.   VIRUS RESEARCH

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

(2008) Takeshi Satoh et al.   CELL

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE