Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

(2019) Daniel Felsky et al.   Nature Communications

Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume

(2019) Grazia Daniela Femminella et al.   NEUROLOGY

In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer’s disease

(2019) Tatsuhiro Terada et al.   JOURNAL OF NEUROLOGY

Priming Microglia for Innate Immune Memory in the Brain

(2019) Jonas J. Neher et al.   TRENDS IN IMMUNOLOGY

[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers

(2019) Donatienne Van Weehaeghe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Cortical microstructural changes along the Alzheimer's disease continuum

(2018) Victor Montal et al.   Alzheimers & Dementia

Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease

(2018) Lorraine Hamelin et al.   BRAIN

Microglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease

(2018) Melanie Dani et al.   BRAIN

Evaluation of11C-BU99008, a positron emission tomography ligand for the Imidazoline2binding site in human brain

(2018) Robin J. Tyacke et al.   JOURNAL OF NUCLEAR MEDICINE

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease

(2018) Andrei G. Vlassenko et al.   NEUROBIOLOGY OF AGING

Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study

(2018) Peter Parbo et al.   NEUROBIOLOGY OF DISEASE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

(2018) Mithilesh Kumar Jha et al.   PROGRESS IN NEUROBIOLOGY

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

(2018) Sonja Rakic et al.   Acta Neuropathologica Communications

Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease

(2018) Stephen F. Carter et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

(2017) Marta Querol-Vilaseca et al.   Journal of Neuroinflammation

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

[18F]FDG PET signal is driven by astroglial glutamate transport

(2017) Eduardo R Zimmer et al.   NATURE NEUROSCIENCE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

(2017) E. F. Goodall et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Cortical laminar tau deposits and activated astrocytes in Alzheimer’s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography

(2017) Laetitia Lemoine et al.   Scientific Reports

In Vivo Imaging of Human Neuroinflammation

(2016) Daniel S. Albrecht et al.   ACS Chemical Neuroscience

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglial immunophenotype in dementia with Alzheimer’s pathology

(2016) Thais Minett et al.   Journal of Neuroinflammation

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Human adult neurogenesis across the ages: An immunohistochemical study

(2016) C. V. Dennis et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta

(2015) H.J. Jyothi et al.   NEUROBIOLOGY OF AGING

TMEM119 marks a subset of microglia in the human brain

(2015) Jun-ichi Satoh et al.   NEUROPATHOLOGY

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

(2015) Michael Schöll et al.   Scientific Reports

Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

(2014) A. A. Sosunov et al.   JOURNAL OF NEUROSCIENCE

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

(2014) C. A. Parker et al.   JOURNAL OF NUCLEAR MEDICINE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition

(2014) Michael W. Marlatt et al.   NEURAL PLASTICITY

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease

(2013) William C. Kreisl et al.   BRAIN

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

3H-Deprenyl and 3H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain

(2013) Amelia Marutle et al.   Journal of Neuroinflammation

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Neuroinflammation in ageing and in neurodegenerative disease

(2013) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Multiple Roles for Astrocytes as Effectors of Cytokines and Inflammatory Mediators

(2013) Michael V. Sofroniew   NEUROSCIENTIST

The role of astrocytes in amyloid β-protein toxicity and clearance

(2012) Dietmar Rudolf Thal   EXPERIMENTAL NEUROLOGY

Molecular imaging of microglia/macrophages in the brain

(2012) Sriram Venneti et al.   GLIA

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

(2012) David H Cribbs et al.   Journal of Neuroinflammation

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Imaging Imidazoline-I2 Binding Sites in Porcine Brain Using 11C-BU99008

(2012) S. Kealey et al.   JOURNAL OF NUCLEAR MEDICINE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammatory phenotype in early Alzheimer's disease

(2012) Tiffany L. Sudduth et al.   NEUROBIOLOGY OF AGING

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106

(2012) Fumihiko Yasuno et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

(2012) Robin J. Tyacke et al.   SYNAPSE

In vivo imaging of astrocytosis in Alzheimer’s disease: an 11C-L-deuteriodeprenyl and PIB PET study

(2011) Alexander Frizell Santillo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

(2011) Markel Olabarria et al.   Molecular Neurodegeneration

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Astrocytes and energy metabolism

(2011) Mateja Prebil et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease

(2010) Masamichi Yokokura et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation

(2010) David R Owen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands

(2010) D. R. J. Owen et al.   JOURNAL OF NUCLEAR MEDICINE

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

(2009) J. E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

(2008) Fumihiko Yasuno et al.   BIOLOGICAL PSYCHIATRY

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

(2008) Fabien Chauveau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The Positron Emission Tomography Ligand DAA1106 Binds With High Affinity to Activated Microglia in Human Neurological Disorders

(2008) Sriram Venneti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY