Evolving mtDNA populations within cells

Mitochondrial Heterogeneity

(2019) Juvid Aryaman et al.   Frontiers in Genetics

A battle for transmission: the cooperative and selfish animal mitochondrial genomes

(2019) Anna Klucnika et al.   Open Biology

No further evidence for paternal leakage of mitochondrial DNA in humans yet

(2019) Sabine Lutz-Bonengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2019) Eunju Kang et al.   NATURE

Germline selection shapes human mitochondrial DNA diversity

(2019) Wei Wei et al.   SCIENCE

An aerobic eukaryotic parasite with functional mitochondria that likely lacks a mitochondrial genome

(2019) Uwe John et al.   Science Advances

Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations

(2019) Hanne Hoitzing et al.   PLoS Computational Biology

The mitochondrial DNA genetic bottleneck: inheritance and beyond

(2018) Haixin Zhang et al.   Essays in Biochemistry

A Population Phylogenetic View of Mitochondrial Heteroplasmy

(2018) Peter R. Wilton et al.   GENETICS

Mutation-specific effects in germline transmission of pathogenic mtDNA variants

(2018) Auke B C Otten et al.   HUMAN REPRODUCTION

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

(2018) Joerg P. Burgstaller et al.   Nature Communications

Do plants have a segregated germline?

(2018) Robert Lanfear   PLOS BIOLOGY

A Population Phylogenetic View of Mitochondrial Heteroplasmy

(2018) Peter R. Wilton et al.   GENETICS

Tension and Resolution: Dynamic, Evolving Populations of Organelle Genomes within Plant Cells

(2018) Iain G. Johnston   Molecular Plant

Biparental Inheritance of Mitochondrial DNA in Humans

(2018) Shiyu Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitigating Mitochondrial Genome Erosion Without Recombination

(2017) Arunas L. Radzvilavicius et al.   GENETICS

Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA

(2017) Iuliia E. Karavaeva et al.   JOURNAL OF CELL SCIENCE

Fission and Fusion of Plant Mitochondria, and Genome Maintenance

(2017) Shin-ichi Arimura   PLANT PHYSIOLOGY

Mitigating Mitochondrial Genome Erosion Without Recombination

(2017) Arunas L. Radzvilavicius et al.   GENETICS

Toward Precision Healthcare: Context and Mathematical Challenges

(2017) Caroline Colijn et al.   Frontiers in Physiology

Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations

(2016) Iain G. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Intercellular mitochondrial transfer: bioenergetic crosstalk between cells

(2016) Pratik Sinha et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches

(2016) Michael V Berridge et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Segregation of Naturally Occurring Mitochondrial DNA Variants in a Mini-Pig Model

(2016) G. Cagnone et al.   GENETICS

Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages

(2016) Dennis V. Lavrov et al.   Genome Biology and Evolution

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

(2016) Mingkun Li et al.   GENOME RESEARCH

Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck

(2016) Ian J. Wilson et al.   HUMAN MOLECULAR GENETICS

De novo mtDNA point mutations are common and have a low recurrence risk

(2016) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies

(2016) E.C. Røyrvik et al.   MOLECULAR HUMAN REPRODUCTION

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

(2016) Louise A. Hyslop et al.   NATURE

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Selfish drive can trump function when animal mitochondrial genomes compete

(2016) Hansong Ma et al.   NATURE GENETICS

Cytoplasmic male sterility (CMS) in hybrid breeding in field crops

(2016) Abhishek Bohra et al.   PLANT CELL REPORTS

Accurate concentration control of mitochondria and nucleoids

(2016) R. Jajoo et al.   SCIENCE

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells

(2016) Auke B.C. Otten et al.   Cell Reports

Selection for Mitochondrial Quality Drives Evolution of the Germline

(2016) Arunas L. Radzvilavicius et al.   PLOS BIOLOGY

Evaluation of predictions of the stochastic model of organelle production based on exact distributions

(2016) C Jeremy Craven   eLife

Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention

(2016) Iain G. Johnston et al.   Cell Systems

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

(2015) Olivier R. Baris et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Plant germline formation: common concepts and developmental flexibility in sexual and asexual reproduction

(2015) A. Schmidt et al.   DEVELOPMENT

Conflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex

(2015) Arunas L. Radzvilavicius et al.   Journal of the Royal Society Interface

Multiple hypothesis correction is vital and undermines reported mtDNA links to diseases including AIDS, cancer, and Huntingdon’s

(2015) Iain G. Johnston   Mitochondrial DNA

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA

(2015) Anitha D. Jayaprakash et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial and plastid genome architecture: Reoccurring themes, but significant differences at the extremes

(2015) David Roy Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial genomes are retained by selective constraints on protein targeting

(2015) Patrik Björkholm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why chloroplasts and mitochondria retain their own genomes and genetic systems: Colocation for redox regulation of gene expression

(2015) John F. Allen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The massive mitochondrial genome of the angiospermSilene noctiflorais evolving by gain or loss of entire chromosomes

(2015) Zhiqiang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions

(2015) Iain G. Johnston et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

(2015) Zhi Yang Tam et al.   PLoS Computational Biology

Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

(2015) Iain G Johnston et al.   eLife

Why are most organelle genomes transmitted maternally?

(2014) Stephan Greiner et al.   BIOESSAYS

Super-resolution microscopy of mitochondria

(2014) Stefan Jakobs et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Genes and Junk in Plant Mitochondria—Repair Mechanisms and Selection

(2014) Alan C. Christensen   Genome Biology and Evolution

Mitochondria and cytoplasmic male sterility in plants

(2014) Jun Hu et al.   MITOCHONDRION

Cytoplasmic male sterility and mitochondrial metabolism in plants

(2014) Pascal Touzet et al.   MITOCHONDRION

Mitochondrial DNA disease and developmental implications for reproductive strategies

(2014) Joerg Patrick Burgstaller et al.   MOLECULAR HUMAN REPRODUCTION

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

(2014) B. Rebolledo-Jaramillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage

(2014) Joerg Patrick Burgstaller et al.   Cell Reports

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

(2014) Shankar Mukherji et al.   eLife

Male Sterility and Fertility Restoration in Crops

(2013) Letian Chen et al.   Annual Review of Plant Biology

Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

(2013) Takashi Makiuchi et al.   BIOCHIMIE

Strikingly Bacteria-Like and Gene-Rich Mitochondrial Genomes throughout Jakobid Protists

(2013) Gertraud Burger et al.   Genome Biology and Evolution

Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis

(2013) Sophie Monnot et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA response to high altitude: A new perspective on high-altitude adaptation

(2013) Yongjun Luo et al.   Mitochondrial DNA

The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro

(2013) Matthew Cotterill et al.   MOLECULAR HUMAN REPRODUCTION

Paternal leakage, heteroplasmy, and the evolution of plant mitochondrial genomes

(2013) David E. McCauley   NEW PHYTOLOGIST

One ring to rule them all? Genome sequencing provides new insights into the ‘master circle’ model of plant mitochondrial DNA structure

(2013) Daniel B. Sloan   NEW PHYTOLOGIST

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle

(2013) Laurent Chatre et al.   NUCLEIC ACIDS RESEARCH

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

(2013) Zhi Yang Tam et al.   PLoS One

mtDNA makes a U-turn for the mitochondrial nucleoid

(2013) Christian Kukat et al.   TRENDS IN CELL BIOLOGY

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans

(2013) David C. Samuels et al.   PLoS Genetics

Insight into mammalian mitochondrial DNA segregation

(2012) Riikka Jokinen et al.   ANNALS OF MEDICINE

The Problem with Mixing Mitochondria

(2012) Nick Lane   CELL

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

(2012) Christoph Freyer et al.   NATURE GENETICS

Selfish Little Circles: Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes

(2012) Katie A. Clark et al.   PLoS One

Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

(2012) Anton K. Raap et al.   PLoS One

Rapid Evolution of Enormous, Multichromosomal Genomes in Flowering Plant Mitochondria with Exceptionally High Mutation Rates

(2012) Daniel B. Sloan et al.   PLOS BIOLOGY

Mitochondrial DNA nucleoid structure

(2011) Daniel F. Bogenhagen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Substoichiometrically Different Mitotypes Coexist in Mitochondrial Genomes of Brassica napus L

(2011) Jianmei Chen et al.   PLoS One

The Strength and Timing of the Mitochondrial Bottleneck in Salmon Suggests a Conserved Mechanism in Vertebrates

(2011) Jonci N. Wolff et al.   PLoS One

Selection for mitonuclear co-adaptation could favour the evolution of two sexes

(2011) Z. Hadjivasiliou et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Previous Estimates of Mitochondrial DNA Mutation Level Variance Did Not Account for Sampling Error: Comparing the mtDNA Genetic Bottleneck in Mice and Humans

(2010) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detecting Heteroplasmy from High-Throughput Sequencing of Complete Human Mitochondrial DNA Genomes

(2010) Mingkun Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Detection of heteroplasmy in individual mitochondrial particles

(2010) Bobby G. Poe et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Mitochondrial fusion, division and positioning in plants: Figure 1

(2010) David C. Logan   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial inheritance in fungi

(2010) Christoph W Basse   CURRENT OPINION IN MICROBIOLOGY

Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups

(2010) Aurora Gómez-Durán et al.   HUMAN MOLECULAR GENETICS

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

Mechanisms for independent cytoplasmic inheritance of mitochondria and plastids in angiosperms

(2010) Noriko Nagata   JOURNAL OF PLANT RESEARCH

Non-genetic heterogeneity from stochastic partitioning at cell division

(2010) Dann Huh et al.   NATURE GENETICS

Diversity and reductive evolution of mitochondria among microbial eukaryotes

(2010) K. Hjort et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fewer genes than organelles: extremely low and variable gene copy numbers in mitochondria of somatic plant cells

(2010) Tobias Preuten et al.   PLANT JOURNAL

Breeding Technologies to Increase Crop Production in a Changing World

(2010) M. Tester et al.   SCIENCE

The dynamic plant chondriome

(2010) David C. Logan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation

(2010) Riikka Jokinen et al.   PLoS Genetics

Pronounced Segregation of Donor Mitochondria Introduced by Bovine Ooplasmic Transfer to the Female Germ-Line1

(2009) Christina Ramires Ferreira et al.   BIOLOGY OF REPRODUCTION

Frequency and Selectivity of Mitochondrial Fusion Are Key to Its Quality Maintenance Function

(2009) Pradeep K. Mouli et al.   BIOPHYSICAL JOURNAL

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

(2009) Jaakko L. O. Pohjoismäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heteroplasmy and stoichiometric complexity of plant mitochondrial genomes--though this be madness, yet there's method in't

(2009) M. Woloszynska   JOURNAL OF EXPERIMENTAL BOTANY

The causes of mutation accumulation in mitochondrial genomes

(2009) M. Neiman et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Do organellar genomes function as long-term redox damage sensors?

(2009) Alan F. Wright et al.   TRENDS IN GENETICS

Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico

(2009) Suresh Kumar Poovathingal et al.   PLoS Computational Biology

The Distribution of Mitochondrial DNA Heteroplasmy Due to Random Genetic Drift

(2008) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases

(2008) Christophe Rocher et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Revealing the hidden complexities of mtDNA inheritance

(2008) DANIEL JAMES WHITE et al.   MOLECULAR ECOLOGY

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

The Mitochondrial Cycle of Arabidopsis Shoot Apical Meristem and Leaf Primordium Meristematic Cells Is Defined by a Perinuclear Tentaculate/Cage-Like Mitochondrion

(2008) J. M. Segui-Simarro et al.   PLANT PHYSIOLOGY

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY

Mitochondrial regulation of flower development

(2007) Jenny Carlsson et al.   MITOCHONDRION