A battle for transmission: the cooperative and selfish animal mitochondrial genomes

Mitochondrial Heterogeneity

(2019) Juvid Aryaman et al.   Frontiers in Genetics

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Mitochondrial DNA Heteroplasmy and Purifying Selection in the Mammalian Female Germ Line

(2018) Stephen P. Burr et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes

(2018) Alba Signes et al.   Essays in Biochemistry

Tissue specific differences in mitochondrial DNA maintenance and expression

(2018) Elena Herbers et al.   MITOCHONDRION

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Progress in mitochondrial replacement therapies

(2018) Mary Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Experimental evidence that thermal selection shapes mitochondrial genome evolution

(2018) Zdeněk Lajbner et al.   Scientific Reports

Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

(2018) Yi Yang et al.   Protein & Cell

Deep-Coverage MPS Analysis of Heteroplasmic Variants within the mtGenome Allows for Frequent Differentiation of Maternal Relatives

(2018) Mitchell Holland et al.   Genes

Concordant divergence of mitogenomes and a mitonuclear gene cluster in bird lineages inhabiting different climates

(2018) Hernán E. Morales et al.   Nature Ecology & Evolution

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

(2018) Sandra R. Bacman et al.   NATURE MEDICINE

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

(2018) Payam A. Gammage et al.   NATURE MEDICINE

Mitochondrial DNA Purifying Selection in Mammals and Invertebrates

(2018) Jonathan M. Palozzi et al.   JOURNAL OF MOLECULAR BIOLOGY

Positive Selection Drove the Adaptation of Mitochondrial Genes to the Demands of Flight and High-Altitude Environments in Grasshoppers

(2018) Xiao-Dong Li et al.   Frontiers in Genetics

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

The on-again, off-again relationship between mitochondrial genomes and species boundaries

(2017) Daniel B. Sloan et al.   MOLECULAR ECOLOGY

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

Mother’s curse neutralizes natural selection against a human genetic disease over three centuries

(2017) Emmanuel Milot et al.   Nature Ecology & Evolution

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

(2016) Bryan L. Gitschlag et al.   Cell Metabolism

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

(2016) Mitsutoshi Yamada et al.   Cell Stem Cell

Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster

(2016) Thomas Ryan Hurd et al.   DEVELOPMENTAL CELL

First live birth using human oocytes reconstituted by spindle nuclear transfer for mitochondrial DNA mutation causing Leigh syndrome

(2016) J. Zhang et al.   FERTILITY AND STERILITY

Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages

(2016) Dennis V. Lavrov et al.   Genome Biology and Evolution

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

(2016) Mingkun Li et al.   GENOME RESEARCH

Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck

(2016) Ian J. Wilson et al.   HUMAN MOLECULAR GENETICS

Paternal Mitochondrial Transmission in Intra-SpeciesCaenorhabditis briggsaeHybrids: Table 1

(2016) Joseph A. Ross et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Developmentally programmed germ cell remodelling by endodermal cell cannibalism

(2016) Yusuff Abdu et al.   NATURE CELL BIOLOGY

Selfish drive can trump function when animal mitochondrial genomes compete

(2016) Hansong Ma et al.   NATURE GENETICS

Sex, Mitochondria, and Genetic Rescue

(2016) Justin C. Havird et al.   TRENDS IN ECOLOGY & EVOLUTION

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

(2016) Nikolay P. Kandul et al.   Nature Communications

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells

(2016) Auke B.C. Otten et al.   Cell Reports

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

(2016) Maulik R Patel et al.   eLife

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

(2016) Rebecca Rojansky et al.   eLife

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

(2016) Andrea Strakova et al.   eLife

Pursuing the quest for better understanding the taxonomic distribution of the system of doubly uniparental inheritance of mtDNA

(2016) Arthur Gusman et al.   PeerJ

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

(2015) Pradeep Reddy et al.   CELL

Single Nucleotides in the mtDNA Sequence Modify Mitochondrial Molecular Function and Are Associated with Sex-Specific Effects on Fertility and Aging

(2015) M. Florencia Camus et al.   CURRENT BIOLOGY

Evidence for frequent and tissue-specific sequence heteroplasmy in human mitochondrial DNA

(2015) Jana Naue et al.   MITOCHONDRION

Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function

(2015) Zhe Chen et al.   MOLECULAR BIOLOGY OF THE CELL

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation

(2015) Felipe K. Teixeira et al.   NATURE CELL BIOLOGY

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Mitochondrial and plastid genome architecture: Reoccurring themes, but significant differences at the extremes

(2015) David Roy Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations

(2015) Mingkun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations

(2015) Zhi Yang Tam et al.   PLoS Computational Biology

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools

(2015) Jun Ding et al.   PLoS Genetics

Selections that isolate recombinant mitochondrial genomes in animals

(2015) Hansong Ma et al.   eLife

Why are most organelle genomes transmitted maternally?

(2014) Stephan Greiner et al.   BIOESSAYS

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

Paternal Mitochondrial Destruction after Fertilization Is Mediated by a Common Endocytic and Autophagic Pathway in Drosophila

(2014) Yoav Politi et al.   DEVELOPMENTAL CELL

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions

(2014) M. C. Kenney et al.   HUMAN MOLECULAR GENETICS

Mitochondrial replacement: from basic research to assisted reproductive technology portfolio tool—technicalities and possible risks

(2014) Lynsey Cree et al.   MOLECULAR HUMAN REPRODUCTION

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

(2014) Hansong Ma et al.   NATURE GENETICS

Mitonuclear interactions: evolutionary consequences over multiple biological scales

(2014) J. N. Wolff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA

(2014) B. Rebolledo-Jaramillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioenergetic Constraints on the Evolution of Complex Life

(2014) N. Lane   Cold Spring Harbor Perspectives in Biology

mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage

(2014) Joerg Patrick Burgstaller et al.   Cell Reports

Keeping mtDNA in Shape between Generations

(2014) James B. Stewart et al.   PLoS Genetics

Female and Male Gamete Mitochondria Are Distinct and Complementary in Transcription, Structure, and Genome Function

(2013) Wilson B.M. de Paula et al.   Genome Biology and Evolution

Mitochondrial DNA response to high altitude: A new perspective on high-altitude adaptation

(2013) Yongjun Luo et al.   Mitochondrial DNA

The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro

(2013) Matthew Cotterill et al.   MOLECULAR HUMAN REPRODUCTION

Unique insights into maternal mitochondrial inheritance in mice

(2013) S.-M. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans

(2013) David C. Samuels et al.   PLoS Genetics

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development

(2012) Steven Z. DeLuca et al.   DEVELOPMENTAL CELL

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

(2012) Daniel Paull et al.   NATURE

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

(2012) Christoph Freyer et al.   NATURE GENETICS

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

The Creation of Cybrids Harboring Mitochondrial Haplogroups in the Taiwanese Population of Ethnic Chinese Background: An ExtensiveIn VitroTool for the Study of Mitochondrial Genomic Variations

(2012) Tsu-Kung Lin et al.   Oxidative Medicine and Cellular Longevity

Selfish Little Circles: Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes

(2012) Katie A. Clark et al.   PLoS One

Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans

(2012) F. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

(2012) Hyo-Sang Lee et al.   Cell Reports

Differences in mtDNA whole sequence between Tibetan and Han populations suggesting adaptive selection to high altitude

(2011) Mingliang Gu et al.   GENE

Population genetics of the cytoplasm and the units of selection on mitochondrial DNA in Drosophila melanogaster

(2011) David M. Rand   GENETICA

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Mitochondrial phylogenomics of the Bivalvia (Mollusca): searching for the origin and mitogenomic correlates of doubly uniparental inheritance of mtDNA

(2010) Hélène Doucet-Beaupré et al.   BMC EVOLUTIONARY BIOLOGY

Is the mitochondrial cloud the selection machinery for preferentially transmitting wild-type mtDNA between generations? Rewinding Müller’s ratchet efficiently

(2010) Rong Rong Zhou et al.   CURRENT GENETICS

Adaptive evolution of the mitochondrial ND6 gene in the domestic horse

(2010) T. Ning et al.   GENETICS AND MOLECULAR RESEARCH

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

Tissue-specific differences in mitochondrial activity and biogenesis

(2010) Erika Fernández-Vizarra et al.   MITOCHONDRION

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Do mitochondrial properties explain intraspecific variation in thermal tolerance?

(2009) N. A. Fangue et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Mitochondrial gene replacement in primate offspring and embryonic stem cells

(2009) Masahito Tachibana et al.   NATURE

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

The Distribution of Mitochondrial DNA Heteroplasmy Due to Random Genetic Drift

(2008) Passorn Wonnapinij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution

(2008) Dana K Howe et al.   BMC EVOLUTIONARY BIOLOGY

Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation

(2008) Mannis van Oven et al.   HUMAN MUTATION

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes

(2008) H. Xu et al.   SCIENCE

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY