State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies

A novel method to generate monocyte-derived dendritic cells during coculture with HaCaT facilitates detection of weak contact allergens in cosmetics

(2016) Janna Frombach et al.   ARCHIVES OF TOXICOLOGY

Integrated decision strategies for skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays

(2016) Donna S. Macmillan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

(2016) Coralie Dumont et al.   TOXICOLOGY IN VITRO

Intra- and inter-laboratory reproducibility and accuracy of the LuSens assay: A reporter gene-cell line to detect keratinocyte activation by skin sensitizers

(2016) Tzutzuy Ramirez et al.   TOXICOLOGY IN VITRO

SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study

(2016) Françoise Cottrez et al.   TOXICOLOGY IN VITRO

Integrated Testing Strategy (ITS) – Opportunities to better use existing data and guide future testing in toxicology

(2016) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy

(2015) Joanna S. Jaworska et al.   ARCHIVES OF TOXICOLOGY

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

(2015) Thomas Luechtefeld et al.   JOURNAL OF APPLIED TOXICOLOGY

A novelin chemicomethod to detect skin sensitizers in highly diluted reaction conditions

(2015) Yusuke Yamamoto et al.   JOURNAL OF APPLIED TOXICOLOGY

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

(2015) Osamu Takenouchi et al.   JOURNAL OF APPLIED TOXICOLOGY

Alternatives for skin sensitisation: Hazard identification and potency categorisation: Report from an EPAA/CEFIC LRI/Cosmetics Europe cross sector workshop, ECHA Helsinki, April 23rd and 24th 2015

(2015) David Basketter et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Assessing skin sensitization hazard in mice and men using non-animal test methods

(2015) Daniel Urbisch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers

(2015) Cristina Avonto et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

(2015) Vinicius M. Alves et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prospective multicentre study of the U-SENS test method for skin sensitization testing

(2015) N. Alépée et al.   TOXICOLOGY IN VITRO

The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization

(2015) Cécile Piroird et al.   TOXICOLOGY IN VITRO

Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay

(2015) Françoise Cottrez et al.   TOXICOLOGY IN VITRO

Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA)

(2014) Anna Sonnenburg et al.   ARCHIVES OF TOXICOLOGY

Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

(2014) Jochem W. van der Veen et al.   CRITICAL REVIEWS IN TOXICOLOGY

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

(2014) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Predicting Skin Sensitizer Potency Based on In Vitro Data from KeratinoSens and Kinetic Peptide Binding: Global Versus Domain-Based Assessment

(2014) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Genomic Allergen Rapid Detection In-House Validation—A Proof of Concept

(2014) Henrik Johansson et al.   TOXICOLOGICAL SCIENCES

LuSens: A keratinocyte based ARE reporter gene assay for use in integrated testing strategies for skin sensitization hazard identification

(2014) Tzutzuy Ramirez et al.   TOXICOLOGY IN VITRO

Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

(2014) Kyoko Tsujita-Inoue et al.   TOXICOLOGY IN VITRO

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Integrated testing strategies for safety assessments

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

Hypersensitivity to oxaliplatin: clinical features and risk factors

(2014) Marie Parel et al.   BMC Pharmacology & Toxicology

Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients

(2013) Osamu Takenouchi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The OSIRIS Weight of Evidence approach: ITS for skin sensitisation

(2013) Emiel Rorije et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Computer models versus reality: How well do in silico models currently predict the sensitization potential of a substance

(2013) Wera Teubner et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An epidermal equivalent assay for identification and ranking potency of contact sensitizers

(2013) Susan Gibbs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis

(2013) Kazutoshi Saito et al.   TOXICOLOGY IN VITRO

Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

(2013) Gavin Maxwell et al.   TOXICOLOGY IN VITRO

Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

(2012) Yuri Dancik et al.   ADVANCED DRUG DELIVERY REVIEWS

Anin vitromethod for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing

(2012) James M. McKim et al.   Cutaneous and Ocular Toxicology

Dermal Clearance Model for Epidermal Bioavailability Calculations

(2012) Rania Ibrahim et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Human T cell priming assay (hTCPA) for the identification of contact allergens based on naive T cells and DC – IFN-γ and TNF-α readout

(2012) Anne Richter et al.   TOXICOLOGY IN VITRO

The GARD assay for assessment of chemical skin sensitizers

(2012) Henrik Johansson et al.   TOXICOLOGY IN VITRO

Applicability of a keratinocyte gene signature to predict skin sensitizing potential

(2012) Jochem W. van der Veen et al.   TOXICOLOGY IN VITRO

NCTC 2544 and IL-18 production: A tool for the identification of contact allergens

(2012) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Proteomic allergen–peptide/protein interaction assay for the identification of human skin sensitizers

(2012) Lisa Dietz et al.   TOXICOLOGY IN VITRO

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency

(2012) Marc Teunis et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

(2011) S. F. Martin et al.   ALLERGY

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

(2011) Henrik Johansson et al.   BMC GENOMICS

Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT)

(2011) Yuko Nukada et al.   CONTACT DERMATITIS

Mathematical models of skin permeability: An overview

(2011) Samir Mitragotri et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

An In Vitro Test to Screen Skin Sensitizers Using a Stable THP-1–Derived IL-8 Reporter Cell Line, THP-G8

(2011) Toshiya Takahashi et al.   TOXICOLOGICAL SCIENCES

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

(2011) Caroline Bauch et al.   TOXICOLOGY IN VITRO

Functionality and specificity of gene markers for skin sensitization in dendritic cells

(2011) Nathalie Lambrechts et al.   TOXICOLOGY LETTERS

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

(2010) Stefan F. Martin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Global QSAR models of skin sensitisers for regulatory purposes

(2010) Qasim Chaudhry et al.   Chemistry Central Journal

Non-animal sensitization testing: State-of-the-art

(2010) Rob J. Vandebriel et al.   CRITICAL REVIEWS IN TOXICOLOGY

A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells

(2010) James M. McKim et al.   Cutaneous and Ocular Toxicology

Assessment of Chemical Skin-Sensitizing Potency by an In Vitro Assay Based on Human Dendritic Cells

(2010) Nathalie Lambrechts et al.   TOXICOLOGICAL SCIENCES

Determining Epidermal Disposition Kinetics for Use in an Integrated Nonanimal Approach to Skin Sensitization Risk Assessment

(2010) Michael Davies et al.   TOXICOLOGICAL SCIENCES

Chemical Allergy: Translating Biology into Hazard Characterization

(2010) I. Kimber et al.   TOXICOLOGICAL SCIENCES

Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials

(2010) Hitoshi Sakaguchi et al.   TOXICOLOGY IN VITRO

A potential in vitro epidermal equivalent assay to determine sensitizer potency

(2010) Guilherme G. dos Santos et al.   TOXICOLOGY IN VITRO

The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories

(2010) Natsch Andreas et al.   TOXICOLOGY IN VITRO

Further development of the NCTC 2544 IL-18 assay to identify in vitro contact allergens

(2010) V. Galbiati et al.   TOXICOLOGY IN VITRO

Gene markers in dendritic cells unravel pieces of the skin sensitization puzzle

(2010) Nathalie Lambrechts et al.   TOXICOLOGY LETTERS

Oxidation of Cell Surface Thiol Groups by Contact Sensitizers Triggers the Maturation of Dendritic Cells

(2009) Saori Kagatani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: Possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate

(2009) Morihiko Hirota et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

(2009) Andreas Natsch   TOXICOLOGICAL SCIENCES

Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System

(2009) G. Frank Gerberick et al.   TOXICOLOGICAL SCIENCES

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

(2009) G. Galvão dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test

(2009) Mie Suzuki et al.   TOXICOLOGY IN VITRO

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Development of a ModifiedIn vitroSkin Absorption Method to Study the Epidermal/Dermal Disposition of a Contact Allergen in Human Skin

(2008) Ruth U. Pendlington et al.   Cutaneous and Ocular Toxicology

Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach

(2008) S.J. Enoch et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

A cell-based in vitro alternative to identify skin sensitizers by gene expression

(2008) Jef Hooyberghs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

(2007) Ann-Therese Karlberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients

(2007) Anne Marie Api et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY