Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

Development of LLNA:DAE: a new local lymph node assay that includes the elicitation phase, discriminates borderline-positive chemicals, and is useful for cross-sensitization testing

(2014) Kunihiko Yamashita et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

Food for Thought … Mechanistic Validation

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Allergic Skin Inflammation Induced by Chemical Sensitizers Is Controlled by the Transcription Factor Nrf2

(2013) Zeina El Ali et al.   TOXICOLOGICAL SCIENCES

Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

(2013) Nicola J. Hewitt et al.   TOXICOLOGICAL SCIENCES

An epidermal equivalent assay for identification and ranking potency of contact sensitizers

(2013) Susan Gibbs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure

(2012) Yuri Dancik et al.   ADVANCED DRUG DELIVERY REVIEWS

Induction of skin sensitization is augmented in Nrf2-deficient mice

(2012) Jochem W. van der Veen et al.   ARCHIVES OF TOXICOLOGY

Variable NAT1 Enzyme Activity in Long-Term Cultured Human HaCaT Keratinocytes

(2012) Simone Scheitza et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation

(2012) Philipp R. Esser et al.   PLoS One

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Applicability of a keratinocyte gene signature to predict skin sensitizing potential

(2012) Jochem W. van der Veen et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY

A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

(2011) Henrik Johansson et al.   BMC GENOMICS

A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity

(2011) S. J. Enoch et al.   CRITICAL REVIEWS IN TOXICOLOGY

Toll-like receptors and skin

(2011) A.T. Ermertcan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

WikiPathways: building research communities on biological pathways

(2011) T. Kelder et al.   NUCLEIC ACIDS RESEARCH

T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

(2010) Stefan F. Martin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic factors in contact allergy-review and future goals

(2010) Axel Schnuch et al.   CONTACT DERMATITIS

Non-animal sensitization testing: State-of-the-art

(2010) Rob J. Vandebriel et al.   CRITICAL REVIEWS IN TOXICOLOGY

Allergic Contact Dermatitis: Novel Mechanisms and Therapeutic Perspectives

(2010) Andrea Cavani et al.   CURRENT DRUG METABOLISM

Keratinocytes in allergic skin diseases

(2010) Cristina Albanesi   Current Opinion in Allergy and Clinical Immunology

A newin vitromethod for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells

(2010) James M. McKim et al.   Cutaneous and Ocular Toxicology

Interleukin-1, inflammasomes and the skin

(2010) Laurence Feldmeyer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker geneID2, by contact sensitizers in human bulge-derived keratinocytes

(2010) Yoshie Yoshikawa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Genome-Wide Expression Analysis of Human In Vivo Irritated Epidermis: Differential Profiles Induced by Sodium Lauryl Sulfate and Nonanoic Acid

(2010) Anders Clemmensen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Keratinocyte Gene Expression Profiles Discriminate Sensitizing and Irritating Compounds

(2010) Rob J. Vandebriel et al.   TOXICOLOGICAL SCIENCES

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identifying and characterizing chemical skin sensitizers without animal testing: Colipa’s research and method development program

(2010) P. Aeby et al.   TOXICOLOGY IN VITRO

Effector and regulatory mechanisms in allergic contact dermatitis

(2009) M. Vocanson et al.   ALLERGY

Contact allergy to allergens of the TRUE-test (panels 1 and 2) has decreased modestly in the general population

(2009) J.P. Thyssen et al.   BRITISH JOURNAL OF DERMATOLOGY

Dendritic cells: biology of the skin

(2009) Mascha J. Toebak et al.   CONTACT DERMATITIS

Management of Occupational Dermatitis

(2009) Shane C. Clark et al.   DERMATOLOGIC CLINICS

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Common and Unique Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence and Smoking Cessation

(2009) Ju Wang et al.   NEUROPSYCHOPHARMACOLOGY

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

(2009) G. Galvão dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells

(2009) Krista Ouwehand et al.   TOXICOLOGY IN VITRO

Presenting and exploring biological pathways with PathVisio

(2008) Martijn P van Iersel et al.   BMC BIOINFORMATICS

Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study

(2008) C.M. de Jongh et al.   BRITISH JOURNAL OF DERMATOLOGY

New aspects in allergic contact dermatitis

(2008) Charlotte Gotthard Mortz et al.   Current Opinion in Allergy and Clinical Immunology

Allergic patch test reactions associated with cosmetics: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004

(2008) Erin M. Warshaw et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway

(2008) Nadège Ade et al.   TOXICOLOGICAL SCIENCES

Characterization of early events involved in human dendritic cell maturation induced by sensitizers: Cross talk between MAPK signalling pathways

(2008) Sandra Trompezinski et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

(2007) Ann-Therese Karlberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Loss-of-Function Mutations in the Filaggrin Gene and Allergic Contact Sensitization to Nickel

(2007) Natalija Novak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin sensitization in chemical risk assessment: Report of a WHO/IPCS international workshop focusing on dose–response assessment

(2007) Henk van Loveren et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY