Non-animal sensitization testing: State-of-the-art

Cutting Edge: Notch Signaling Induces a Distinct Cytokine Profile in Dendritic Cells That Supports T Cell-Mediated Regulation and IL-2-Dependent IL-17 Production

(2014) L. Bugeon et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Proteins HSP27 and HSP70 Are Present in the Skin and Are Important Mediators of Allergic Contact Hypersensitivity

(2014) N. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Dermal Dendritic Cells, and Not Langerhans Cells, Play an Essential Role in Inducing an Immune Response

(2014) A. Fukunaga et al.   JOURNAL OF IMMUNOLOGY

Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic ElectrophilesApplication to α,β-Unsaturated Ketones, Acrylates, and Propiolates

(2009) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Electrophilic Reaction Chemistry of Low Molecular Weight Respiratory Sensitizers

(2009) Steven J. Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

High Throughput Kinetic Profiling Approach for Covalent Binding to Peptides: Application to Skin Sensitization Potency of Michael Acceptor Electrophiles

(2009) David W. Roberts et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Gene expression studies in cultured dendritic cells: new indicators for the discrimination of skin sensitizers and irritantsin vitro

(2009) S. Szameit et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain

(2009) Terry Wayne Schultz et al.   CONTACT DERMATITIS

Methods for the prediction of low-molecular-weight occupational respiratory sensitizers

(2009) Martin J Seed et al.   Current Opinion in Allergy and Clinical Immunology

The local lymph node assay compared with the human maximization test as an indicator of allergic potency in humans using patch test clinic populations

(2009) Danny Zaghi et al.   Cutaneous and Ocular Toxicology

The human repeated insult patch test in the 21st century: A commentary

(2009) David A. Basketter   Cutaneous and Ocular Toxicology

The Nrf2-Keap1-ARE Toxicity Pathway as a Cellular Sensor for Skin Sensitizers—Functional Relevance and a Hypothesis on Innate Reactions to Skin Sensitizers

(2009) Andreas Natsch   TOXICOLOGICAL SCIENCES

Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System

(2009) G. Frank Gerberick et al.   TOXICOLOGICAL SCIENCES

Reactivity Profiling: Covalent Modification of Single Nucleophile Peptides for Skin Sensitization Risk Assessment

(2009) Maja Aleksic et al.   TOXICOLOGICAL SCIENCES

THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers

(2009) Nathalie Lambrechts et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

(2009) G. Galvão dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)

(2008) Hitoshi Sakaguchi et al.   CELL BIOLOGY AND TOXICOLOGY

A Comparison of Reactivity Schemes for the Prediction Skin Sensitization Potential

(2008) Grace Patlewicz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitative and Mechanistic Read Across for Predicting the Skin Sensitization Potential of Alkenes Acting via Michael Addition

(2008) Steven James Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction

(2008) Francesco Liotta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA

(2008) Hirokazu Kinoshita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

(2008) Stefan F. Martin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dose metrics in the acquisition of skin sensitization: Thresholds and importance of dose per unit area

(2008) Ian Kimber et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Nonanimal Alternatives for Skin Sensitization: Letter to the Editor

(2008) David W. Roberts et al.   TOXICOLOGICAL SCIENCES

The Respiratory Local Lymph Node Assay as a Tool to Study Respiratory Sensitizers

(2008) Josje H. E. Arts et al.   TOXICOLOGICAL SCIENCES

LC-MS–Based Characterization of the Peptide Reactivity of Chemicals to Improve the In Vitro Prediction of the Skin Sensitization Potential

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

HMOX1 and NQO1 Genes are Upregulated in Response to Contact Sensitizers in Dendritic Cells and THP-1 Cell Line: Role of the Keap1/Nrf2 Pathway

(2008) Nadège Ade et al.   TOXICOLOGICAL SCIENCES

Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: Identification of discriminating genetic markers and pathway analysis

(2008) Sandra Verstraelen et al.   TOXICOLOGY

A cell-based in vitro alternative to identify skin sensitizers by gene expression

(2008) Jef Hooyberghs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of early events involved in human dendritic cell maturation induced by sensitizers: Cross talk between MAPK signalling pathways

(2008) Sandra Trompezinski et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization

(2008) S. Verstraelen et al.   TOXICOLOGY IN VITRO

Leiden reconstructed human epidermal model as a tool for the evaluation of the skin corrosion and irritation potential according to the ECVAM guidelines

(2008) A. El Ghalbzouri et al.   TOXICOLOGY IN VITRO

Reconstruction of three-dimensional human skin model composed of dendritic cells, keratinocytes and fibroblasts utilizing a handy scaffold of collagen vitrigel membrane

(2008) T. Uchino et al.   TOXICOLOGY IN VITRO

Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: Identification of discriminating genetic markers and pathway analysis

(2008) Sandra Verstraelen et al.   TOXICOLOGY LETTERS

Determinants of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY

A review of critical factors in the conduct and interpretation of the human repeat insult patch test

(2007) Pauline M. McNamee et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Respiratory sensitization and allergy: Current research approaches and needs

(2007) Darrell R. Boverhof et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY