Integrated decision strategies for skin sensitization hazard

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships

(2015) Thomas Luechtefeld et al.   JOURNAL OF APPLIED TOXICOLOGY

Evaluation of combinations ofin vitrosensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization

(2015) Morihiko Hirota et al.   JOURNAL OF APPLIED TOXICOLOGY

Test battery with the human cell line activation test, direct peptide reactivity assay and DEREK based on a 139 chemical data set for predicting skin sensitizing potential and potency of chemicals

(2015) Osamu Takenouchi et al.   JOURNAL OF APPLIED TOXICOLOGY

New Publicly Available Chemical Query Language, CSRML, To Support Chemotype Representations for Application to Data Mining and Modeling

(2015) Chihae Yang et al.   Journal of Chemical Information and Modeling

Assessing skin sensitization hazard in mice and men using non-animal test methods

(2015) Daniel Urbisch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

(2015) Kerstin Reisinger et al.   TOXICOLOGY IN VITRO

Development of a multiparametricin vitromodel of skin sensitization

(2014) Muriel Guyard-Nicodème et al.   JOURNAL OF APPLIED TOXICOLOGY

Development and utilization of anex vivobromodeoxyuridine local lymph node assay protocol for assessing potential chemical sensitizers

(2014) W. C. Williams et al.   JOURNAL OF APPLIED TOXICOLOGY

Towards AOP application – Implementation of an integrated approach to testing and assessment (IATA) into a pipeline tool for skin sensitization

(2014) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

(2014) Jochem W. van der Veen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

(2014) Kyoko Tsujita-Inoue et al.   TOXICOLOGY IN VITRO

Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case

(2014) Joanna Jaworska   ALTEX-Alternatives to Animal Experimentation

From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

(2014) Cameron MacKay   ALTEX-Alternatives to Animal Experimentation

Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network

(2014) Jason R. Pirone   ALTEX-Alternatives to Animal Experimentation

15 Years Out: Reinventing ICCVAM

(2013) Linda S. Birnbaum   ENVIRONMENTAL HEALTH PERSPECTIVES

Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients

(2013) Osamu Takenouchi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Utility of Rat Liver S9 Fractions to Study Skin-Sensitizing Prohaptens in a Modified KeratinoSens Assay

(2013) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Non-animal test methods for predicting skin sensitization potentials

(2012) Annette Mehling et al.   ARCHIVES OF TOXICOLOGY

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT)

(2011) Yuko Nukada et al.   CONTACT DERMATITIS

The regulatory use of the Local Lymph Node Assay for the notification of new chemicals in Europe

(2011) Alexandre Angers-Loustau et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluating the sensitization potential of surfactants: Integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach

(2011) Nicholas Ball et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals

(2011) Caroline Bauch et al.   TOXICOLOGY IN VITRO

The Reach Perspective: Toward a New Concept of Toxicity Testing

(2010) Greet Schoeters   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Chemical Allergy: Translating Biology into Hazard Characterization

(2010) I. Kimber et al.   TOXICOLOGICAL SCIENCES

Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro

(2010) Roger Emter et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials

(2010) Hitoshi Sakaguchi et al.   TOXICOLOGY IN VITRO

The European Union’s REACH regulation: a review of its history and requirements

(2009) E. Spencer Williams et al.   CRITICAL REVIEWS IN TOXICOLOGY

Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System

(2009) G. Frank Gerberick et al.   TOXICOLOGICAL SCIENCES

Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)

(2008) R. Kreiling et al.   FOOD AND CHEMICAL TOXICOLOGY

Filling the Concept with Data: Integrating Data from Different In Vitro and In Silico Assays on Skin Sensitizers to Explore the Battery Approach for Animal-Free Skin Sensitization Testing

(2008) Andreas Natsch et al.   TOXICOLOGICAL SCIENCES

Determinants of skin sensitisation potential

(2007) David W. Roberts et al.   JOURNAL OF APPLIED TOXICOLOGY