Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

PPARs and pain

(2018) Bright N Okine et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potential interactions among phenolic compounds and probiotics for mutual boosting of their health-promoting properties and food functionalities – A review

(2018) Evandro Leite de Souza et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Dietary polyphenols and type 2 diabetes: Human study and clinical trials

(2018) Hui Cao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

(2018) Saikat Dewanjee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin

(2018) Pranay Srivastava et al.   NEUROTOXICOLOGY

Cyanidin-3-O-glucoside inhibits different enzymes involved in central nervous system pathologies and type-2 diabetes

(2018) Guillermo Cásedas et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signalling pathway

(2018) Sajad Fakhri et al.   EUROPEAN JOURNAL OF PAIN

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

(2017) David Porras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

(2017) Shirin Pournourmohammadi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy

(2017) Navpreet Kaur et al.   JOURNAL OF ETHNOPHARMACOLOGY

The dietary constituent resveratrol suppresses nociceptive neurotransmission via the NMDA receptor

(2017) Shiori Takehana et al.   Molecular Pain

Differential Molecular Targets for Neuroprotective Effect of Chlorogenic Acid and its Related Compounds Against Glutamate Induced Excitotoxicity and Oxidative Stress in Rat Cortical Neurons

(2017) Olfa Rebai et al.   NEUROCHEMICAL RESEARCH

Bacosine isolated from aerial parts of Bacopa monnieri improves the neuronal dysfunction in Streptozotocin-induced diabetic neuropathy

(2017) Lalit Kishore et al.   Journal of Functional Foods

Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity

(2016) Arumugam Ramakrishnan et al.   BIOMEDICINE & PHARMACOTHERAPY

6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain

(2016) Shehla Akbar et al.   BIOMEDICINE & PHARMACOTHERAPY

Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice

(2016) G. Smilin Bell Aseervatham et al.   BIOMEDICINE & PHARMACOTHERAPY

NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801

(2016) Hila Roshanravan et al.   DIABETES

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update

(2016) Niloy Bhattacharjee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes

(2016) Ryan B. Griggs et al.   JOURNAL OF PAIN

Anti-obesity effects of resveratrol: comparison between animal models and humans

(2016) Alfredo Fernández-Quintela et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

GW27-e0657 Resveratrol Protects against oxidized LDL-induced foam cells formation and apoptosis through inhibition of ER stress and downregulation of CD36

(2016) Hui Zhang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus

(2016) Rania M. Khalil et al.   NEUROSIGNALS

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Effects of curcumin and captopril on the functions of kidney and nerve in streptozotocin-induced diabetic rats: role of angiotensin converting enzyme 1

(2015) Eman S.H. Abd Allah et al.   Applied Physiology Nutrition and Metabolism

Nociceptive spinal cord neurons of laminae I–III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate (EGCG)

(2015) D. Raposo et al.   BRAIN RESEARCH BULLETIN

Role of Peroxynitrite in the Development of Diabetic Peripheral Neuropathy: Table 1

(2015) Joshua F. Edwards et al.   DIABETES CARE

Protection of curcumin against amyloid-β-induced cell damage and death involves the prevention from NMDA receptor-mediated intracellular Ca2+elevation

(2015) Han-Chang Huang et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity

(2015) Yoshinori Mikami et al.   LIFE SCIENCES

Resveratrol Prevents Retinal Dysfunction by Regulating Glutamate Transporters, Glutamine Synthetase Expression and Activity in Diabetic Retina

(2015) Kaihong Zeng et al.   NEUROCHEMICAL RESEARCH

Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

(2015) Salim S. Al-Rejaie et al.   NEUROLOGICAL RESEARCH

Astragaloside IV Attenuates Glutamate-Induced Neurotoxicity in PC12 Cells through Raf-MEK-ERK Pathway

(2015) Rongcai Yue et al.   PLoS One

Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism

(2015) Ilaria Zanotti et al.   Food & Function

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Pharmacologic Interventions for Painful Diabetic Neuropathy

(2014) Marcio L. Griebeler et al.   ANNALS OF INTERNAL MEDICINE

Antineuropathic effect of 7-hydroxy-3,4-dihydrocadalin in streptozotocin-induced diabetic rodents

(2014) Héctor Isaac Rocha-González et al.   BMC Complementary and Alternative Medicine

The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus

(2014) Tahereh Arablou et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

(2014) Deniz Bagdas et al.   JOURNAL OF MEDICINAL FOOD

Activation of spinal GABAB receptors normalizes N-methyl-D-aspartate receptor in diabetic neuropathy

(2014) Hui-Ping Bai et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stress and inflammation in diabetes-induced nephrotoxic rats

(2014) Omolola R. Ayepola et al.   PHYTOMEDICINE

Oxidative stress mediated by NMDA, AMPA/KA channels in acute hippocampal slices: Neuroprotective effect of resveratrol

(2014) André Quincozes-Santos et al.   TOXICOLOGY IN VITRO

Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats

(2014) SD AlSharari et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?

(2014) Caroline M. Freitag et al.   Frontiers in Cellular Neuroscience

Neuroprotective effect of resveratrol in diabetic cerebral ischemic-reperfused rats through regulation of inflammatory and apoptotic events

(2014) Hoda E Mohamed et al.   Diabetology & Metabolic Syndrome

Resveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons

(2014) Kyu Suk Cho et al.   Food & Function

Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells

(2014) Eun-Ju Yang et al.   Food & Function

Involvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells

(2013) Yong Son et al.   AMINO ACIDS

Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy

(2013) Eugen V. Khomula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway

(2013) Hualei Guo et al.   CARDIOVASCULAR DRUGS AND THERAPY

Pathogenesis of diabetic neuropathy: Focus on neurovascular mechanisms

(2013) P. Sytze Van Dam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carvacrol Attenuates Diabetes-Associated Cognitive Deficits in Rats

(2013) Wenjing Deng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Protective effects of resveratrol on glutamate-induced damages in murine brain cultures

(2013) Rudolf Moldzio et al.   JOURNAL OF NEURAL TRANSMISSION

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains

(2013) Keun-Sung Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Health effects of olive oil polyphenols: Recent advances and possibilities for the use of health claims

(2013) Sandra Martín-Peláez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord

(2013) Wei-Cheng Zhao et al.   NEUROSCIENCE LETTERS

Quercetin inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex

(2013) Cheng-Wei Lu et al.   NEUROTOXICOLOGY

Functional and Morphological Effects of Grape Seed Proanthocyanidins on Peripheral Neuropathy in Rats with Type 2 Diabetes Mellitus

(2013) Ye Ding et al.   PHYTOTHERAPY RESEARCH

Novel pathogenic pathways in diabetic neuropathy

(2013) Jennifer Zenker et al.   TRENDS IN NEUROSCIENCES

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats

(2012) Hanan Naeim Attia et al.   BEHAVIOURAL PHARMACOLOGY

NMDA and AMPA receptor mediated excitotoxicity in cerebral cortex of streptozotocin induced diabetic rat: Ameliorating effects of curcumin

(2012) S. Jayanarayanan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Role of Glutamate in Diabetic and in Chemotherapy Induced Peripheral Neuropathies and its Regulation by Glutamate Carboxypeptidase II

(2012) V. A. Carozzi et al.   CURRENT MEDICINAL CHEMISTRY

Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic neurop

(2012) N. Hotta et al.   DIABETIC MEDICINE

Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy

(2012) Amit D. Kandhare et al.   FITOTERAPIA

Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization

(2012) Tzu Yu Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol Attenuates Peripheral Neuropathy in Streptozotocin-Induced Diabetes in Rats

(2012) Giuseppe Ristagno et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

TRP channels and analgesia

(2012) Louis S. Premkumar et al.   LIFE SCIENCES

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test

(2012) Lin Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy

(2012) Somsuvra B. Ghatak et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

(2011) Pál Brasnyó et al.   BRITISH JOURNAL OF NUTRITION

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary polyphenols in the prevention and treatment of allergic diseases

(2011) A. Singh et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Cinnamon Intake Lowers Fasting Blood Glucose: Meta-Analysis

(2011) Paul A. Davis et al.   JOURNAL OF MEDICINAL FOOD

The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis

(2011) R. Hursel et al.   Obesity Reviews

Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

(2011) Parviz Khajehdehi et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Different Roles of 12/15-Lipoxygenase in Diabetic Large and Small Fiber Peripheral and Autonomic Neuropathies

(2010) Irina G. Obrosova et al.   AMERICAN JOURNAL OF PATHOLOGY

NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy

(2010) Ashutosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

Aldose Reductase and Cardiovascular Diseases, Creating Human-Like Diabetic Complications in an Experimental Model

(2010) Ravichandran Ramasamy et al.   CIRCULATION RESEARCH

Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database

(2010) J Pérez-Jiménez et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level

(2010) Jixu Yu et al.   FEBS LETTERS

Impact of Dietary Polyphenols on Carbohydrate Metabolism

(2010) Kati Hanhineva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basic biochemical mechanisms behind the health benefits of polyphenols

(2010) Cesar G. Fraga et al.   MOLECULAR ASPECTS OF MEDICINE

Evidence for neurotrophic factors associating with TRPV1 gene expression in the inflamed human esophagus

(2010) K. R. Shieh et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

(2010) Tourandokht Baluchnejadmojarad et al.   NEUROSCIENCE LETTERS

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Mechanism of diabetic neuropathy: Where are we now and where to go?

(2010) Soroku Yagihashi et al.   Journal of Diabetes Investigation

Dietary Polyphenols and Obesity

(2010) Mohsen Meydani et al.   Nutrients

Abnormal calcium homeostasis in peripheral neuropathies

(2009) Paul Fernyhough et al.   CELL CALCIUM

Dual Angiogenic and Neurotrophic Effects of Bone Marrow–Derived Endothelial Progenitor Cells on Diabetic Neuropathy

(2009) Jin-Ok Jeong et al.   CIRCULATION

Development of Selective Axonopathy in Adult Sensory Neurons Isolated From Diabetic Rats: Role of Glucose-Induced Oxidative Stress

(2009) E. Zherebitskaya et al.   DIABETES

Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

(2009) J. L. Edwards et al.   DIABETOLOGIA

Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy

(2009) John Doupis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Interactions of gut microbiota with functional food components and nutraceuticals

(2009) J.M. Laparra et al.   PHARMACOLOGICAL RESEARCH

Protective effects of vitamin E and curcumin on l-thyroxine-induced rat testicular oxidative stress

(2008) Dipak Kumar Sahoo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aldose Reductase, Still a Compelling Target for Diabetic Neuropathy

(2008) Peter Oates   CURRENT DRUG TARGETS

Pro-Inflammatory Mechanisms in Diabetic Neuropathy: Focus on the Nuclear Factor Kappa B Pathway

(2008) Norman Cameron et al.   CURRENT DRUG TARGETS

Role of Advanced Glycation End Products in Diabetic Neuropathy

(2008) Kazuhiro Sugimoto et al.   CURRENT PHARMACEUTICAL DESIGN

Depletion of capsaicin sensitive afferents prevents lamina-dependent increases in spinal N-methyl-d-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats

(2008) Dae-Hyun Roh et al.   EUROPEAN JOURNAL OF PAIN

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inhibitory effect of glutamate release from rat cerebrocortical nerve terminals by resveratrol

(2008) Yi Chang et al.   NEUROCHEMISTRY INTERNATIONAL

A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes

(2008) Tomonori Nagao et al.   Obesity

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE