Target identification for biologically active small molecules using chemical biology approaches
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Target identification for biologically active small molecules using chemical biology approaches
Authors
Keywords
Small molecule, High throughput screen, Target identification, Chemical biology, Drug discovery, Affinity based approach
Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 39, Issue 9, Pages 1193-1201
Publisher
Springer Nature
Online
2016-07-08
DOI
10.1007/s12272-016-0791-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Nonspecific protein labeling of photoaffinity linkers correlates with their molecular shapes in living cells
- (2016) Hankum Park et al. CHEMICAL COMMUNICATIONS
- Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation
- (2016) Pu-Hyeon Cha et al. Nature Chemical Biology
- Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase
- (2016) Panayotis C Theodoropoulos et al. Nature Chemical Biology
- Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery
- (2015) Hye Jin Jung et al. ARCHIVES OF PHARMACAL RESEARCH
- Photoaffinity labeling in target- and binding-site identification
- (2015) Ewan Smith et al. Future Medicinal Chemistry
- Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling
- (2015) Danny Hung-Chieh Chou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
- (2015) Ujunwa C Okoye-Okafor et al. Nature Chemical Biology
- Functional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs
- (2015) Alexey Chernobrovkin et al. Scientific Reports
- RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule
- (2014) Satish Srinivas Kitambi et al. CELL
- A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation
- (2014) Sanghee Lee et al. Nature Chemical Biology
- Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack
- (2013) Slava Ziegler et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182
- (2013) Tsukasa Mizuhara et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Target identification of biologically active small molecules via in situ methods
- (2013) Ying Su et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Target deconvolution techniques in modern phenotypic profiling
- (2013) Jiyoun Lee et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Combinatorial drug screening identifies synergistic co-targeting of Bruton’s tyrosine kinase and the proteasome in mantle cell lymphoma
- (2013) M Axelrod et al. LEUKEMIA
- Target identification of small molecules based on chemical biology approaches
- (2013) Yushi Futamura et al. Molecular BioSystems
- Recent Advances in Target Characterization and Identification by Photoaffinity Probes
- (2013) Jitapa Sumranjit et al. MOLECULES
- Target identification and mechanism of action in chemical biology and drug discovery
- (2013) Monica Schenone et al. Nature Chemical Biology
- Affinity-based target identification for bioactive small molecules
- (2013) Makoto Kawatani et al. MedChemComm
- Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis
- (2012) Jongmin Park et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Discovery of small molecule cancer drugs: Successes, challenges and opportunities
- (2012) Swen Hoelder et al. Molecular Oncology
- A Phthalimide Derivative That Inhibits Centrosomal Clustering Is Effective on Multiple Myeloma
- (2012) Hirokazu Shiheido et al. PLoS One
- Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis
- (2012) M. M. P. Schulz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Stem Cell-Based Approach to Cartilage Repair
- (2012) K. Johnson et al. SCIENCE
- Identification of Small Molecule Activators of Cryptochrome
- (2012) T. Hirota et al. SCIENCE
- The Binding of Fluorophores to Proteins Depends on the Cellular Environment
- (2011) Yun Kyung Kim et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Identification and validation of bioactive small molecule target through phenotypic screening
- (2011) Yoon Sun Cho et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Role of natural product diversity in chemical biology
- (2011) Jiyong Hong CURRENT OPINION IN CHEMICAL BIOLOGY
- Selective killing of cancer cells by a small molecule targeting the stress response to ROS
- (2011) Lakshmi Raj et al. NATURE
- Natural product–inspired cascade synthesis yields modulators of centrosome integrity
- (2011) Heiko Dückert et al. Nature Chemical Biology
- Bugs, drugs and chemical genomics
- (2011) Terry Roemer et al. Nature Chemical Biology
- Natural Products as Chemical Probes
- (2010) Erin E. Carlson ACS Chemical Biology
- Identification of Direct Protein Targets of Small Molecules
- (2010) Brett Lomenick et al. ACS Chemical Biology
- Biochemical Target Isolation for Novices: Affinity-Based Strategies
- (2010) Shin-ichi Sato et al. CHEMISTRY & BIOLOGY
- Use of phage display technology for the determination of the targets for small-molecule therapeutics
- (2010) Yoichi Takakusagi et al. Expert Opinion on Drug Discovery
- Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing
- (2010) Hye Jin Jung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The identification of cellular targets of 17β estradiol using a lytic (T7) cDNA phage display approach
- (2010) Bieke Van Dorst et al. TOXICOLOGY IN VITRO
- Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling
- (2009) Nag S. Kumar et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A Small Molecule Primes Embryonic Stem Cells for Differentiation
- (2009) Shoutian Zhu et al. Cell Stem Cell
- Phosphatidylethanolamine-Binding Proteins, Including RKIP, Exhibit Affinity for Phosphodiesterase-5 Inhibitors
- (2009) Poupak Dadvar et al. CHEMBIOCHEM
- Identifying the proteins to which small-molecule probes and drugs bind in cells
- (2009) S.-E. Ong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Target identification using drug affinity responsive target stability (DARTS)
- (2009) B. Lomenick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic methods for drug target discovery
- (2008) Lekha Sleno et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Small molecules and chemical tools at the interface
- (2008) Robert H Newman et al. Nature Chemical Biology
- Combination chemical genetics
- (2008) Joseph Lehár et al. Nature Chemical Biology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now