Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

(2012) Marcus Bantscheff et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Natural Product Inspired Tetrahydropyran Collection Yields Mitosis Modulators that Synergistically Target CSE1L and Tubulin

(2012) Tobias Voigt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding

(2012) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors

(2012) Joanna M. Krysiak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis

(2012) Jongmin Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

(2012) Dominic Hoepfner et al.   Cell Host & Microbe

Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiae

(2012) Anja Wilmes et al.   GENE

Dabigatran and Dabigatran Ethyl Ester: Potent Inhibitors of Ribosyldihydronicotinamide Dehydrogenase (NQO2)

(2012) Simon Michaelis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target Identification by Chromatographic Co-elution: Monitoring of Drug-Protein Interactions without Immobilization or Chemical Derivatization

(2012) Janet N. Y. Chan et al.   MOLECULAR & CELLULAR PROTEOMICS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Direct identification of ligand-receptor interactions on living cells and tissues

(2012) Andreas P Frei et al.   NATURE BIOTECHNOLOGY

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

(2012) Chuan-Xu Liu et al.   Nature Chemical Biology

A Phthalimide Derivative That Inhibits Centrosomal Clustering Is Effective on Multiple Myeloma

(2012) Hirokazu Shiheido et al.   PLoS One

Simplified proteomics approach to discover protein-ligand interactions

(2012) Youngil Chang et al.   PROTEIN SCIENCE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

A photocleavable affinity tag for the enrichment of alkyne-modified biomolecules

(2012) Timo Koopmans et al.   RSC Advances

Identification of Drug Targets In Vitro and in Living Cells by Soluble-Nanopolymer-Based Proteomics

(2011) Lianghai Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphopeptide-Dependent Labeling of 14-3-3 ζ Proteins by Fusicoccin-Based Fluorescent Probes

(2011) Michiko Takahashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Chemical Genetics–Based Target Identification in Drug Discovery

(2011) Feng Cong et al.   Annual Review of Pharmacology and Toxicology

Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells

(2011) Ulrich Elling et al.   Cell Stem Cell

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

What makes a good drug target?

(2011) Isabella Gashaw et al.   DRUG DISCOVERY TODAY

AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy

(2011) Yoshimi Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

(2011) Chun-wa Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Energetics-Based Discovery of Protein–Ligand Interactions on a Proteomic Scale

(2011) Pei-Fen Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing small molecule–protein interactions: A new perspective for functional proteomics

(2011) Thomas Lenz et al.   Journal of Proteomics

Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells

(2011) Jürgen Eirich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome

(2011) Yuko Arita et al.   Molecular BioSystems

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Natural product–inspired cascade synthesis yields modulators of centrosome integrity

(2011) Heiko Dückert et al.   Nature Chemical Biology

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

(2011) Christopher Chidley et al.   Nature Chemical Biology

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

(2011) Alexander Adibekian et al.   Nature Chemical Biology

Natural products reveal cancer cell dependence on oxysterol-binding proteins

(2011) Anthony W G Burgett et al.   Nature Chemical Biology

Bugs, drugs and chemical genomics

(2011) Terry Roemer et al.   Nature Chemical Biology

Erratum: The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

(2011) Nagaratna S. Hegde et al.   Nature Chemistry

Harnessing synthetic lethal interactions in anticancer drug discovery

(2011) Denise A. Chan et al.   NATURE REVIEWS DRUG DISCOVERY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B

(2011) Kengo Morohashi et al.   PLoS One

Identification of Genes Affecting the Toxicity of Anti-Cancer Drug Bortezomib by Genome-Wide Screening in S. pombe

(2011) Kojiro Takeda et al.   PLoS One

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

(2011) S. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

(2011) J. H. Reiling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

Arabidopsis methyltransferase fingerprints by affinity-based protein profiling

(2010) Lisette Wirsing et al.   ANALYTICAL BIOCHEMISTRY

A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling

(2010) Paul P. Geurink et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Reactivity of Natural Product-Derived γ-Butyrolactones

(2010) Martin H. Kunzmann et al.   BIOCHEMISTRY

Synthesis of Conjugates of 6-Aminophenanthridine and Guanabenz, Two Structurally Unrelated Prion Inhibitors, for the Determination of Their Cellular Targets by Affinity Chromatography

(2010) Fabienne Gug et al.   BIOCONJUGATE CHEMISTRY

Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor

(2010) Jinesh Gheeya et al.   CANCER LETTERS

Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases

(2010) Christian Dalhoff et al.   CHEMBIOCHEM

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides

(2010) Jason E. Hein et al.   CHEMICAL SOCIETY REVIEWS

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

Biochemical Target Isolation for Novices: Affinity-Based Strategies

(2010) Shin-ichi Sato et al.   CHEMISTRY & BIOLOGY

Comparative Analysis of Cleavable Azobenzene-Based Affinity Tags for Bioorthogonal Chemical Proteomics

(2010) Yu-Ying Yang et al.   CHEMISTRY & BIOLOGY

Barcode technology in yeast: application to pharmacogenomics

(2010) Daniela Delneri   FEMS YEAST RESEARCH

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

(2010) Christian A. Luber et al.   IMMUNITY

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

(2010) Hye Jin Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening†

(2010) Thomas Weidemann et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Proteomics Analysis of Cellular Imatinib Targets and their Candidate Downstream Effectors

(2010) Susanne B. Breitkopf et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative Analysis of the Intra- and Inter-Individual Variability of the Normal Urinary Proteome

(2010) Nagarjuna Nagaraj et al.   JOURNAL OF PROTEOME RESEARCH

Two-dimensional gel electrophoresis in proteomics: Past, present and future

(2010) Thierry Rabilloud et al.   Journal of Proteomics

A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

(2010) Benjamin W. Jester et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria

(2010) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor

(2010) Luigi Margarucci et al.   Molecular BioSystems

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

(2010) Dong-Uk Kim et al.   NATURE BIOTECHNOLOGY

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

(2010) Shinichi Nishimura et al.   Nature Chemical Biology

A universal TagModule collection for parallel genetic analysis of microorganisms

(2010) Julia Oh et al.   NUCLEIC ACIDS RESEARCH

Protein Microarrays: Novel Developments and Applications

(2010) Luis Berrade et al.   PHARMACEUTICAL RESEARCH

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements

(2010) G. M. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

cDNA phage display as a novel tool to screen for cellular targets of chemical compounds

(2010) Bieke Van Dorst et al.   TOXICOLOGY IN VITRO

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

The Ras Pathway Modulator Melophlin A Targets Dynamins

(2009) Tanja Knoth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

(2009) T. Sanda et al.   BLOOD

Phosphatidylethanolamine-Binding Proteins, Including RKIP, Exhibit Affinity for Phosphodiesterase-5 Inhibitors

(2009) Poupak Dadvar  et al.   CHEMBIOCHEM

Useful Tools for Biomolecule Isolation, Detection, and Identification: Acylhydrazone-Based Cleavable Linkers

(2009) Ki Duk Park et al.   CHEMISTRY & BIOLOGY

Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects

(2009) Yama A. Abassi et al.   CHEMISTRY & BIOLOGY

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth

(2009) Sayumi Yamazoe et al.   CHEMISTRY & BIOLOGY

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

(2009) Jens-Uwe Peters et al.   ChemMedChem

Identifying druggable disease-modifying gene products

(2009) Scott J Dixon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of novel hair-growth inducers by means of connectivity mapping

(2009) Yumiko Ishimatsu-Tsuji et al.   FASEB JOURNAL

Quantitative phenotyping via deep barcode sequencing

(2009) A. M. Smith et al.   GENOME RESEARCH

MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules

(2009) Zhixiang Zhang et al.   INVESTIGATIONAL NEW DRUGS

Capture of Drug Targets from Live Cells Using a Multipurpose Immuno-Chemo-Proteomics Tool

(2009) Chaitanya Saxena et al.   JOURNAL OF PROTEOME RESEARCH

Comprehensive Identification of Staurosporine-Binding Kinases in the Hepatocyte Cell Line HepG2 using Capture Compound Mass Spectrometry (CCMS)

(2009) Jenny J. Fischer et al.   JOURNAL OF PROTEOME RESEARCH

Marinopyrrole A Target Elucidation by Acyl Dye Transfer

(2009) Chambers C. Hughes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Electrochemical Sensor for the Detection of Protein−Small Molecule Interactions Directly in Serum and Other Complex Matrices

(2009) Kevin J. Cash et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Quantitative Comparison of the Membrane Proteomes of Self-renewing and Differentiating Human Embryonic Stem Cells

(2009) Tatyana A. Prokhorova et al.   MOLECULAR & CELLULAR PROTEOMICS

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

(2009) Jordi Mestres et al.   Molecular BioSystems

A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124

(2009) Poupak Dadvar et al.   Molecular BioSystems

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Synthesis and application of a new cleavable linker for “click”-based affinity chromatography

(2009) Felicetta Landi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

(2009) Jenny J. Fischer et al.   TOXICOLOGICAL SCIENCES

Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

(2009) Sabine Kuettel et al.   PLoS Neglected Tropical Diseases

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

(2009) Nicoletta Bivi et al.   GENOME BIOLOGY

Enantiodifferential Approach for the Detection of the Target Membrane Protein of the Jasmonate Glycoside that Controls the Leaf Movement ofAlbizzia saman

(2008) Yoko Nakamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Strategies for Generating Protein Biochips

(2008) Pascal Jonkheijm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ammosamides A and B Target Myosin

(2008) Chambers C. Hughes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

(2008) D. C. Taussig et al.   BLOOD

SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function

(2008) Marcus Krüger et al.   CELL

Biology-inspired synthesis of compound libraries

(2008) M. Kaiser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F by Using Reverse Chemical Proteomics

(2008) Andrew M. Piggott et al.   CHEMBIOCHEM

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS

A Ligand-Based Approach to Mining the Chemogenomic Space of Drugs

(2008) Elisabet Gregori-Puigjane et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   FEBS LETTERS

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition

(2008) Nobumoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

(2008) Laura Trinkle-Mulcahy et al.   JOURNAL OF CELL BIOLOGY

Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases

(2008) William L. Scott et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

An Immuno-Chemo-Proteomics Method for Drug Target Deconvolution

(2008) Chaitanya Saxena et al.   JOURNAL OF PROTEOME RESEARCH

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

Enhancing Drug Accumulation in Saccharomyces cerevisiae by Repression of Pleiotropic Drug Resistance Genes with Chimeric Transcription Repressors

(2008) A. Stepanov et al.   MOLECULAR PHARMACOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

An integrated platform of genomic assays reveals small-molecule bioactivities

(2008) Shawn Hoon et al.   Nature Chemical Biology

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

(2008) Darren J. Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays

(2008) Cathrin Schnack et al.   PROTEOMICS

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

(2008) Fung-Ming Siu et al.   PROTEOMICS

Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols

(2008) Naoki Kanoh et al.   TETRAHEDRON