Affinity-based target identification for bioactive small molecules

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Affinity-based screening of MDM2/MDMX–p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

(2013) Taro Noguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Target identification of small molecules based on chemical biology approaches

(2013) Yushi Futamura et al.   Molecular BioSystems

Systems-level antimicrobial drug and drug synergy discovery

(2013) Terry Roemer et al.   Nature Chemical Biology

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Chemical reporters for biological discovery

(2013) Markus Grammel et al.   Nature Chemical Biology

Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

(2012) Yukiko Sasazawa et al.   ACS Chemical Biology

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry

(2012) David J. Lapinsky   BIOORGANIC & MEDICINAL CHEMISTRY

Boron-Based Inhibitors of Acyl Protein Thioesterases 1 and 2

(2012) Tobias J. Zimmermann et al.   CHEMBIOCHEM

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

High-throughput Screening Identifies Small Molecule Inhibitors of Molecular Chaperones

(2012) Yasumitsu Kondoh et al.   CURRENT PHARMACEUTICAL DESIGN

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target Identification by Chromatographic Co-elution: Monitoring of Drug-Protein Interactions without Immobilization or Chemical Derivatization

(2012) Janet N. Y. Chan et al.   MOLECULAR & CELLULAR PROTEOMICS

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells

(2012) Chuan-Xu Liu et al.   Nature Chemical Biology

A Phthalimide Derivative That Inhibits Centrosomal Clustering Is Effective on Multiple Myeloma

(2012) Hirokazu Shiheido et al.   PLoS One

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity

(2011) Shun Minagawa et al.   BIOCHEMICAL JOURNAL

Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound

(2011) Satoshi Sakamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

(2011) Makoto Kawatani et al.   CHEMISTRY & BIOLOGY

Vipirinin, a Coumarin-based HIV-1 Vpr Inhibitor, Interacts with a Hydrophobic Region of VPR

(2011) Eugene Boon Beng Ong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

(2011) Marco Bürger et al.   JOURNAL OF LIPID RESEARCH

Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach

(2011) Xijun Wang et al.   Journal of Proteomics

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

(2011) Christopher Chidley et al.   Nature Chemical Biology

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B

(2011) Kengo Morohashi et al.   PLoS One

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

(2010) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases

(2010) Christian Dalhoff et al.   CHEMBIOCHEM

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

Biochemical Target Isolation for Novices: Affinity-Based Strategies

(2010) Shin-ichi Sato et al.   CHEMISTRY & BIOLOGY

Metabolomic Identification of the Target of the Filopodia Protrusion Inhibitor Glucopiericidin A

(2010) Mitsuhiro Kitagawa et al.   CHEMISTRY & BIOLOGY

Target Profiling of a Small Library of Phosphodiesterase 5 (PDE5) Inhibitors using Chemical Proteomics

(2010) Reinout Raijmakers et al.   ChemMedChem

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

(2010) Hye Jin Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

(2010) Hyun Seung Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

(2010) Shinichi Nishimura et al.   Nature Chemical Biology

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

(2010) Isao Miyazaki et al.   Nature Chemical Biology

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements

(2010) G. M. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

(2009) Naoki Kanoh et al.   BIOCONJUGATE CHEMISTRY

Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases

(2009) Makoto Kawatani et al.   CANCER SCIENCE

FLAG tagging by CuAAC and nanogram-scale purification of the target protein for a bioactive metabolite involved in circadian rhythmic leaf movement in Leguminosae

(2009) Yoshiyuki Manabe et al.   CHEMICAL COMMUNICATIONS

Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing

(2009) Chunping Xu et al.   CHEMISTRY & BIOLOGY

GDP-Capture Compound — A novel tool for the profiling of GTPases in pro- and eukaryotes by capture compound mass spectrometry (CCMS)

(2009) Yan Luo et al.   Journal of Proteomics

Marinopyrrole A Target Elucidation by Acyl Dye Transfer

(2009) Chambers C. Hughes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

(2009) Jenny J. Fischer et al.   TOXICOLOGICAL SCIENCES

Recent advances and method development for drug target identification

(2009) Janet N.Y. Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chemical Strategies for Generating Protein Biochips

(2008) Pascal Jonkheijm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ammosamides A and B Target Myosin

(2008) Chambers C. Hughes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

(2008) Isao MIYAZAKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Small-molecule microarrays as tools in ligand discovery

(2008) Arturo J. Vegas et al.   CHEMICAL SOCIETY REVIEWS

Chemical Proteomics-Based Drug Design: Target and Antitarget Fishing with a Catechol−Rhodanine Privileged Scaffold for NAD(P)(H) Binding Proteins

(2008) Xia Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Immuno-Chemo-Proteomics Method for Drug Target Deconvolution

(2008) Chaitanya Saxena et al.   JOURNAL OF PROTEOME RESEARCH

Photocrosslinkers illuminate interactions in living cells

(2008) Yoshihito Tanaka et al.   Molecular BioSystems

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

(2008) A. A. Cohen et al.   SCIENCE

Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols

(2008) Naoki Kanoh et al.   TETRAHEDRON