Target identification of small molecules based on chemical biology approaches

Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

(2012) Yukiko Sasazawa et al.   ACS Chemical Biology

The expanding field of SILAC

(2012) Shao-En Ong   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis

(2012) Jongmin Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

(2012) W. C. Reinhold et al.   CANCER RESEARCH

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Construction of a microbial natural product library for chemical biology studies

(2012) Naoki Kato et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

High-throughput Screening Identifies Small Molecule Inhibitors of Molecular Chaperones

(2012) Yasumitsu Kondoh et al.   CURRENT PHARMACEUTICAL DESIGN

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

(2012) O. Ryan et al.   SCIENCE

Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers

(2011) Eriko Sumiya et al.   ACS Chemical Biology

Pattern Recognition Approaches and Computational Systems Tools for Ultra Performance Liquid Chromatography–Mass Spectrometry-Based Comprehensive Metabolomic Profiling and Pathways Analysis of Biological Data Sets

(2011) Xijun Wang et al.   ANALYTICAL CHEMISTRY

Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors

(2011) Petra Ross-Macdonald et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cleavable linkers in chemical biology

(2011) Geoffray Leriche et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genetic and proteomic approaches to identify cancer drug targets

(2011) G Roti et al.   BRITISH JOURNAL OF CANCER

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

(2011) Derek F. Ceccarelli et al.   CELL

Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic Profiling

(2011) Makoto Kawatani et al.   CHEMISTRY & BIOLOGY

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph

(2011) Shinsuke Ohnuki et al.   FEMS YEAST RESEARCH

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

(2011) Marco Bürger et al.   JOURNAL OF LIPID RESEARCH

Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach

(2011) Xijun Wang et al.   Journal of Proteomics

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Padanamides A and B, Highly Modified Linear Tetrapeptides Produced in Culture by aStreptomycessp. Isolated from a Marine Sediment

(2011) David. E. Williams et al.   ORGANIC LETTERS

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study

(2011) Lun Yang et al.   PLoS Computational Biology

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system

(2010) De-xin Kong et al.   ACTA PHARMACOLOGICA SINICA

Optimization and Evaluation of Metabolite Extraction Protocols for Untargeted Metabolic Profiling of Liver Samples by UPLC-MS

(2010) Perrine Masson et al.   ANALYTICAL CHEMISTRY

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of Phosphatidylinositol 3-Kinase Inhibitory Compounds from the Screening Committee of Anticancer Drugs (SCADS) Library

(2010) Dexin Kong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Introduction of New Tools for Chemical Biology Research on Microbial Metabolites

(2010) Hiroyuki OSADA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction

(2010) Stefano Leone et al.   CANCER LETTERS

Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status:In silicoand Biological Evaluations

(2010) Shingo Dan et al.   CANCER RESEARCH

Synthesis of S-Adenosyl-L-homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases

(2010) Christian Dalhoff et al.   CHEMBIOCHEM

Application of Proteomic Profiling Based on 2D-DIGE for Classification of Compounds According to the Mechanism of Action

(2010) Makoto Muroi et al.   CHEMISTRY & BIOLOGY

Metabolomic Identification of the Target of the Filopodia Protrusion Inhibitor Glucopiericidin A

(2010) Mitsuhiro Kitagawa et al.   CHEMISTRY & BIOLOGY

Target Profiling of a Small Library of Phosphodiesterase 5 (PDE5) Inhibitors using Chemical Proteomics

(2010) Reinout Raijmakers et al.   ChemMedChem

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

(2010) Hye Jin Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

(2010) P. D. Caie et al.   MOLECULAR CANCER THERAPEUTICS

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

(2010) Mariam Aghajan et al.   NATURE BIOTECHNOLOGY

Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

(2010) Shinichi Nishimura et al.   Nature Chemical Biology

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

(2010) Isao Miyazaki et al.   Nature Chemical Biology

Phenomics: the next challenge

(2010) David Houle et al.   NATURE REVIEWS GENETICS

High-Content, Image-Based Screening for Drug Targets in Yeast

(2010) Shinsuke Ohnuki et al.   PLoS One

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements

(2010) G. M. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue

(2010) Hiroyuki Yamakoshi et al.   ACS Medicinal Chemistry Letters

Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

(2009) Naoki Kanoh et al.   BIOCONJUGATE CHEMISTRY

The combined status of ATM and p53 link tumor development with therapeutic response

(2009) H. Jiang et al.   GENES & DEVELOPMENT

Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids inCandida albicans

(2009) Deming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multidimensional quantification of subcellular morphology of Saccharomyces cerevisiae using CalMorph, the high-throughput image-processing program

(2009) Takahiro Negishi et al.   JOURNAL OF BIOTECHNOLOGY

GDP-Capture Compound — A novel tool for the profiling of GTPases in pro- and eukaryotes by capture compound mass spectrometry (CCMS)

(2009) Yan Luo et al.   Journal of Proteomics

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances and method development for drug target identification

(2009) Janet N.Y. Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mass spectrometry for proteomics

(2008) Xuemei Han et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Global Analysis of Gel Mobility of Proteins and Its Use in Target Identification

(2008) Atsuko Shirai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Proteomics-Based Drug Design: Target and Antitarget Fishing with a Catechol−Rhodanine Privileged Scaffold for NAD(P)(H) Binding Proteins

(2008) Xia Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytosine methylation profiling of cancer cell lines

(2008) M. Ehrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

(2008) A. A. Cohen et al.   SCIENCE

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE