Recent Advances in Target Characterization and Identification by Photoaffinity Probes

Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease

(2013) Christina J. Crump et al.   BIOCHEMISTRY

Improving bioorthogonal protein ubiquitylation by click reaction

(2013) Daniel Schneider et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182

(2013) Tsukasa Mizuhara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture

(2013) Partha Sarathi Addy et al.   CHEMICAL COMMUNICATIONS

L-Phototryptophan

(2013) Thomas Wartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Photoreactive 2-Phenethylamine Derivatives - Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling

(2013) Yuta Murai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Identification of Propofol Binding Sites in a Nicotinic Acetylcholine Receptor with a Photoreactive Propofol Analog

(2013) Selwyn S. Jayakar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals

(2013) D. Zeng et al.   JOURNAL OF NUCLEAR MEDICINE

A new family of bioorthogonally applicable fluorogenic labels

(2013) András Herner et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two-Dimensional Gel Electrophoresis

(2012) Jongmin Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells

(2012) Andreas Rennhack et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry

(2012) David J. Lapinsky   BIOORGANIC & MEDICINAL CHEMISTRY

Development of clickable active site-directed photoaffinity probes for γ-secretase

(2012) Christina J. Crump et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases

(2012) Jingyan Ge et al.   CHEMICAL COMMUNICATIONS

Comprehensive Synthesis of Photoreactive (3-Trifluoromethyl)diazirinyl Indole Derivatives from 5- and 6- Trifluoroacetylindoles for Photoaffinity Labeling

(2012) Yuta Murai et al.   JOURNAL OF ORGANIC CHEMISTRY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorogenic Azidofluoresceins for Biological Imaging

(2012) Peyton Shieh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interactions of the Antitumor Macrolide Aplyronine A with Actin and Actin-Related Proteins Established by Its Versatile Photoaffinity Derivatives

(2012) Masaki Kita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling

(2011) Lianne I. Willems et al.   ACCOUNTS OF CHEMICAL RESEARCH

Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

(2011) Christina J. Crump et al.   ACS Chemical Neuroscience

Phosphatidylinositol 3,4,5-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners

(2011) Meng M. Rowland et al.   BIOCHEMISTRY

Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes: Design, physico-chemical properties and preliminary functional investigations

(2011) Benoît Hilbold et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins

(2011) Rongsheng E. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A general method for affinity-based proteomic profiling of exo-α-glycosidases

(2011) Michael N. Gandy et al.   CHEMICAL COMMUNICATIONS

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties

(2011) Emilia Pǎunescu et al.   DYES AND PIGMENTS

Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes

(2011) Raghupathi Neelarapu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling

(2011) Oliver A. Battenberg et al.   JOURNAL OF ORGANIC CHEMISTRY

Bioorthogonal chemistry: recent progress and future directions

(2010) Reyna K. V. Lim et al.   CHEMICAL COMMUNICATIONS

Design and synthesis of an all-in-one 3-(1,1-difluoroprop-2-ynyl)-3H-diazirin-3-yl functional group for photo-affinity labeling

(2009) Nag S. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Iron-Catalyzed Ligand-Free Three-Component Coupling Reactions of Aldehydes, Terminal Alkynes, and Amines

(2009) Pinhua Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Application of Prenyl-Derived Photoaffinity Probes

(2009) Lingdong LI et al.   CHINESE JOURNAL OF CHEMISTRY

Indium-Catalyzed Highly Efficient Three-Component Coupling of Aldehyde, Alkyne, and Amine via C−H Bond Activation

(2009) Yicheng Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Probing the Structure of the Affinity-Purified and Lipid-ReconstitutedTorpedoNicotinic Acetylcholine Receptor†

(2008) Ayman K. Hamouda et al.   BIOCHEMISTRY

Development of bifunctional photoactivatable benzophenone probes and their application to glycoside substrates

(2008) Nir Qvit et al.   BIOPOLYMERS

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS

General Approach to the Total Synthesis of 9-Methoxy-Substituted Indole Alkaloids: Synthesis of Mitragynine, as well as 9-Methoxygeissoschizol and 9-Methoxy-Nb-methylgeissoschizol

(2008) Jun Ma et al.   JOURNAL OF ORGANIC CHEMISTRY

Photochemistry of 7-azide-1-ethyl-3-carboxylate-6,8-difluoroquinolone: a novel reagent for photoaffinity labeling

(2008) Elisa Leyva et al.   TETRAHEDRON LETTERS