Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia–Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brain

Immunomodulatory properties of quercetin-3-O-α-L-rhamnopyranoside from Rapanea melanophloeos against influenza a virus

(2018) Parvaneh Mehrbod et al.   BMC Complementary and Alternative Medicine

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Therapeutic potential of quercetin as a cardiovascular agent

(2018) Rahul V. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers

(2018) Arjun Patra et al.   International Journal of Nanomedicine

TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathway

(2018) Li Hao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart

(2018) Nitin A. Das et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders

(2018) Adaze Bijou Enogieru et al.   Oxidative Medicine and Cellular Longevity

Quercetin Shows the Pharmacological Activity to Simultaneously Downregulate the Inflammatory and Fibrotic Responses to Tissue Injury in Association with its Ability to Target Multi-Kinases

(2018) Ju-Yong Song et al.   PHARMACOLOGY

Roles of some antioxidants in modulation of cardiac myopathy induced by sodium nitrite via down-regulation of mRNA expression of NF-κB, Bax, and flt-1 and suppressing DNA damage

(2018) Laila Mohamed Fadda et al.   SAUDI PHARMACEUTICAL JOURNAL

Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of Edgeworthia gardneri

(2018) Manjiao Zhuang et al.   Drug Design Development and Therapy

A powerful on line ABTS+–CE-DAD method to screen and quantify major antioxidants for quality control of Shuxuening Injection

(2018) Huifen Ma et al.   Scientific Reports

Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries

(2018) Ming Lyu et al.   Frontiers in Pharmacology

Topical TWEAK Accelerates Healing of Experimental Burn Wounds in Mice

(2018) Jing Liu et al.   Frontiers in Pharmacology

Danhong Injection Reversed Cardiac Abnormality in Brain–Heart Syndrome via Local and Remote β-Adrenergic Receptor Signaling

(2018) John O. Orgah et al.   Frontiers in Pharmacology

TWEAK Receptor Deficiency Has Opposite Effects on Female and Male Mice Subjected to Neonatal Hypoxia–Ischemia

(2018) Anton Kichev et al.   Frontiers in Neurology

Standardized Ginkgo biloba extract EGb 761® attenuates early brain injury following subarachnoid hemorrhage via suppressing neuronal apoptosis through the activation of Akt signaling

(2018) Ting Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

(2017) Nicola E. Wilsher et al.   FOOD AND CHEMICAL TOXICOLOGY

Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk

(2017) Allison B. Goldfine et al.   JOURNAL OF CLINICAL INVESTIGATION

Danshen injection prevents heart failure by attenuating post-infarct remodeling

(2017) Lingyan Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke

(2017) H. Mahdessian et al.   JOURNAL OF INTERNAL MEDICINE

Actions of Quercetin, a Polyphenol, on Blood Pressure

(2017) Yoshinori Marunaka et al.   MOLECULES

Ginkgolide B Suppresses TLR4-Mediated Inflammatory Response by Inhibiting the Phosphorylation of JAK2/STAT3 and p38 MAPK in High Glucose-Treated HUVECs

(2017) Kun Chen et al.   Oxidative Medicine and Cellular Longevity

Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion

(2017) Jing-Yan Han et al.   PHARMACOLOGY & THERAPEUTICS

TWEAK/Fn14 signaling in tumors

(2017) Guanglei Hu et al.   TUMOR BIOLOGY

Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells

(2017) Yueying Li et al.   Oncology Letters

TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis

(2017) Daniel Sidler et al.   Nature Communications

Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-κB axis

(2017) Feng Guan et al.   Oncotarget

Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection

(2017) Ming Lyu et al.   Scientific Reports

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Activates Type I Interferon Signals in Lupus Nephritis

(2017) Leixi Xue et al.   Biomed Research International

EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse

(2016) Wenbin Wan et al.   EXPERIMENTAL GERONTOLOGY

Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression

(2016) J.L. Zheng et al.   GENETICS AND MOLECULAR RESEARCH

Amelioration of cardiac dysfunction and ventricular remodeling after myocardial infarction by danhong injection are critically contributed by anti-TGF-β-mediated fibrosis and angiogenesis mechanisms

(2016) Jingrui Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Blood-brain barrier specific permeability assay reveals N -methylated tyramine derivatives in standardised leaf extracts and herbal products of Ginkgo biloba

(2016) Árpád Könczöl et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Preparation and Physicochemical and Pharmacokinetic Characterization of Ginkgo Lactone Nanosuspensions for Antiplatelet Aggregation

(2016) Tian-Qi Rui et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies

(2016) Danina M. Muntean et al.   Oxidative Medicine and Cellular Longevity

Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission

(2016) Fang Li et al.   Scientific Reports

Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae)

(2015) Marie Geneviève Djouossi et al.   BMC Complementary and Alternative Medicine

Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions

(2015) Jingrui Chen et al.   Drug Design Development and Therapy

The protective effect of ginko bilboa leaves injection on the brain dopamine in the rat model of cerebral ischemia/reperfusion injury

(2014) J Gu et al.   African Health Sciences

Cognitive impairment and cardiovascular diseases in the elderly. A heart–brain continuum hypothesis

(2014) Pasquale Abete et al.   AGEING RESEARCH REVIEWS

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential

(2014) A. Priyanka et al.   FREE RADICAL RESEARCH

Ginkgo biloba extract postconditioning reduces myocardial ischemia reperfusion injury

(2014) K. Ran et al.   GENETICS AND MOLECULAR RESEARCH

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood–brain barrier cell model

(2014) Shuwei Ma et al.   LIFE SCIENCES

Phytochemical and medicinal importance ofGinkgo bilobaL.

(2014) Tapan Kumar Mohanta et al.   NATURAL PRODUCT RESEARCH

Atrial Fibrillation in Patients with Cryptogenic Stroke

(2014) David J. Gladstone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryptogenic Stroke and Underlying Atrial Fibrillation

(2014) Tommaso Sanna et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective effect and mechanism of Ginkgo biloba extract-EGb 761 on STZ-induced diabetic cardiomyopathy in rats

(2014) ArminderSingh Saini et al.   Pharmacognosy Magazine

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

(2014) Shao-hua Shi et al.   PLoS One

A New Micro–Computed Tomography–Based High-Resolution Blood–Brain Barrier Imaging Technique to Study Ischemic Stroke

(2014) Jin-Yong Park et al.   STROKE

TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases

(2014) Luis M. Blanco-Colio   Frontiers in Immunology

Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel

(2013) Xin Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice

(2013) A Son et al.   Mucosal Immunology

Oxidative Stress Is Involved in the Pathogenesis of Keshan Disease (an Endemic Dilated Cardiomyopathy) in China

(2013) Junrui Pei et al.   Oxidative Medicine and Cellular Longevity

Ischemic Stroke Brain Sends Indirect Cell Death Signals to the Heart

(2013) Hiroto Ishikawa et al.   STROKE

Microvascular protection is essential for successful neuroprotection in stroke

(2012) Yasemin Gursoy-Ozdemir et al.   JOURNAL OF NEUROCHEMISTRY

Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation

(2012) Thomas H. Sanderson et al.   MOLECULAR NEUROBIOLOGY

Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining

(2012) Estelle Rousselet et al.   Jove-Journal of Visualized Experiments

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Two New Ginkgolides from the Leaves ofGinkgo biloba

(2011) Hua-Jun Liao et al.   PLANTA MEDICA

Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats

(2010) E. Mustonen et al.   Acta Physiologica

Soluble TWEAK is markedly upregulated in patients with ST-elevation myocardial infarction and related to an adverse short-term outcome

(2010) Emmanuel Chorianopoulos et al.   ATHEROSCLEROSIS

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death

(2010) W.B. Haile et al.   NEUROSCIENCE

Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals

(2009) Teris A. van Beek et al.   JOURNAL OF CHROMATOGRAPHY A

Cytochrome P450 ω-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion

(2008) Xiaojun Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke

(2008) Ioana Inta et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY