Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zihui Zhang, Wenhua Jiang, Chan Zhang, Yue Yin, Nan Mu, Yishi Wang, Lu Yu, Heng Ma
Summary: Through a multi-level study from molecule to animal model, these findings uncover the key role of frataxin in inhibiting cardiomyocyte ferroptosis and provide new strategies and perspectives for the treatment of myocardial I/R injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qingqing Wang, Zihou Liu, Rui Wang, Run Li, Xiaoru Lian, Yanquan Yang, Jiao Yan, Zhiqi Yin, Guangji Wang, Jianguo Sun, Ying Peng
Summary: This study investigated the additional benefits of Ginkgo biloba extract (GBE) in combination with statins for the treatment of dyslipidaemia. The results showed that the combination therapy significantly improved blood lipid parameters, reduced liver fat content, and had additional liver protection. GBE also regulated abnormal lipid metabolism and increased the exposure of statins in plasma, providing important implications for disease progression and statin resistance.
Article
Chemistry, Medicinal
Fernanda Malanconi Thomaz, Jussara de Jesus Simao, Viviane Simoes da Silva, Meira Maria Forcelini Machado, Lila Missae Oyama, Eliane Beraldi Ribeiro, Maria Isabel Cardoso Alonso Vale, Monica Marques Telles
Summary: The study found that Ginkgo biloba extract (GbE) can modulate adipocyte differentiation, increasing lipid content and gene expression of major adipogenesis markers. GbE can modify key proteins involved in the differentiation process and accelerate the expression of mature adipocyte proteins.
Article
Nanoscience & Nanotechnology
Yazhong Wei, Minfang Zhu, Saiqi Li, Ting Hong, Xiaoyu Guo, Yongyong Li, Yiqiong Liu, Xumin Hou, Bin He
Summary: PDA@M, a nanoplatform, can target infarcted myocardium to provide antioxidative and antipyroptosis functions for myocardial protection against MI/RI-induced oxidative stress. The results demonstrate that PDA@M significantly reduces infarct size and improves cardiac function post-MI/RI.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, Jingui Yu
Summary: The study found that propofol can protect the myocardium from I/R injury by inhibiting ferroptosis and the AKT/p53 signaling pathway. This research provides a theoretical basis for understanding the prevention and treatment of myocardial ischemia/reperfusion injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Tingting Chen, Yiqiang Chen, Kaiyuan Li, Zhuo Chen, Qingyu Zhao, Yimeng Fan, Ying Liu, Suxia Zhang, Zhihui Hao
Summary: Ginkgo biloba extract (GBE) can modulate intestinal microbiota, decrease pro-inflammatory factors, elevate intestinal integrity, and protect animals from Citrobacter rodentium (CR)-induced colitis. Therefore, GBE should be seriously considered in the preventive control of CR-induced colitis and the development of effective and safe therapeutic strategies for controlling IBD.
Article
Neurosciences
Wen Dong, Ting Gong, Shunying Zhao, Shaohong Wen, Qingfang Chen, Mingyu Jiang, Weizhen Ye, Qiuru Huang, Chunjuan Wang, Chunmei Yang, Xiangrong Liu, Yongjun Wang
Summary: The comprehensive effects of Ginkgo biloba L. leaf extract (GBE) on cerebral ischemia remained unclear. This study investigated the effect of a novel GBE (nGBE) on inflammation, white matter integrity, and long-term neurological function in an experimental stroke model. The results showed that nGBE significantly reduced infarct volume, improved sensorimotor and cognitive functions, inhibited microglia-related inflammation, and promoted white matter repair.
Article
Chemistry, Medicinal
Yun Wang, Yuanyuan Xu, Xiaowei Xu, Hong Wang, Dong Wang, Wenchao Yan, Jiaying Zhu, Haiping Hao, Guangji Wang, Lijuan Cao, Jun Zhang
Summary: This study confirmed the beneficial effects of Ginkgo biloba leave extract (GbE) in alleviating hypercholesterolemia, inflammation, and atherosclerosis. GbE treatment reshaped the intestinal microbiota, downregulated proinflammatory cytokines, and enhanced the expression of tight junction proteins. It also reversed the dysfunction of microbial metabolic phenotypes and reduced atherosclerotic plaque areas. These findings provide important insights into the pharmacological mechanism underlying the antiatherogenic efficacy of GbE.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Han-Yang Lin, Wen-Hao Li, Chen-Feng Lin, Hao-Ran Wu, Yun-Peng Zhao
Summary: This article provides detailed information on the biology of Ginkgo biloba, covering its ecological characteristics, distribution, habitat, responses to environment and biotic factors, physiological structure, reproductive and seed characters, and the impact of diseases and pests. Ginkgo has a strong adaptability globally, with high tolerance to temperature variations, drought, and fire. Stem rot and leaf blight are common diseases in nursery seedlings and juvenile trees, which can be mitigated through shading and fertilization. Ginkgo biloba is one of the world's most distinctive trees, with significant importance in plant evolution and human society.
JOURNAL OF ECOLOGY
(2022)
Article
Chemistry, Physical
Shujun Chen, Hai Zhang, Yujie Qiang, Bochuan Tan, Yuanhui Wu, Siyi Chen
Summary: A self-assembled monolayer (SAM) based on Ginkgo biloba exocarp extract (GBEE) was successfully formed on a copper surface, exhibiting efficient inhibition behavior. Characterization of the GBEE SAM using Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and contact angle tests confirmed the hydrophobic nature of the SAM. Electrochemical measurements and scanning electron microscopy revealed that the SAM showed excellent anti-corrosion performance with a high inhibition efficiency of 97.86%. Theoretical calculations were also conducted to further understand the adsorption and inhibition mechanism of the GBEE SAM.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nanoscience & Nanotechnology
Liqiang Yang, Juanjuan Peng, Aiping Shi, Xueshen Wang, Junyao Li, Yaoquan Su, Kunpeng Yin, Lingzhi Zhao, Yanli Zhao
Summary: Cardioprotective medication has limited effectiveness in relieving myocardial ischemia/reperfusion (I/R) injury. By using nanomedicine for myocardium-targeted delivery, the concentration of therapeutic drugs in the injured myocardium can be significantly increased, leading to effective protection against cardiac damage.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Medicinal
Jia Ke, Meng-Ting Li, Ya-Jing Huo, Yan-Qiong Cheng, Shu-Fen Guo, Yang Wu, Lei Zhang, Jianpeng Ma, Ai-Jun Liu, Yan Han
Summary: Our study showed that the combination of GBE50 and aspirin could enhance the antiplatelet effects by synergistic and additive effects, with stronger inhibition of platelet aggregation. GBE50 interfered with platelet aggregation through cAMP pathway, AA metabolism and calcium signaling pathway, while aspirin regulated platelet aggregation through AA metabolism and platelet activation. Demonstrating the potential application of GBE50 as a supplementary therapy for thrombosis-related diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ke Wang, Yuan Chen, Xue Zhu, Wenjun Zou, Fanfan Zhou
Summary: The study demonstrates the protective effect of Ginkgo biloba extract (GBE) on photoreceptors against white light-induced oxidative damage. This effect is mediated through the modulation of CAV-1-redoxosome signaling, showing potential therapeutic benefits in preventing retinal degenerative diseases.
Article
Chemistry, Multidisciplinary
Chaoqun Nie, A. Rong, Jing Wang, Shuang Pan, Rentong Zou, Bin Wang, Shuiqing Xi, Xiaojian Hong, Meifang Zhou, Haoyu Wang, Mengshu Yu, Lina Wu, Xilin Sun, Wei Yang
Summary: H-2-PFOB nanoemulsions (NEs) with high hydrogen loading capacity are developed for targeted therapy of ischemic myocardium, exhibiting excellent antioxidant and anti-inflammatory properties. The uptake of H-2-PFOB NEs in ischemia-reperfusion myocardium and its influence on F-19-MR signal can be visualized using a 9.4T MR imaging system.