Article
Biotechnology & Applied Microbiology
Honghua Niu, Wenchao Song, Dongyang Pei, Chen Ma, Fudong Liu, Yan Li, Shuaiwei Han
Summary: This study reveals that down-regulation of HDAC3 can promote the recovery of SCI by regulating miR-19b-1-5p and inhibiting the activation of JAK2/STAT3 pathway, leading to improvements in inflammation, pathological damage, apoptosis, and GFAP expression.
Article
Neurosciences
Jie Han, Zhen Hua, Wen-jie Yang, Shu Wang, Fang Yan, Jun-nan Wang, Tao Sun
Summary: In this study, the analgesic effect of Resveratrol (Res) and its underlying mechanism were investigated in a rat model of spinal cord injury (SCI). The results showed that intrathecal administration with Res effectively alleviated mechanical allodynia in rats with SCI. It was also found that Res suppressed the production of pro-inflammatory factors and inhibited the expressions of the JAK2/STAT3 signaling pathway. These findings suggest that Res has the potential to be an effective treatment for neuropathic pain following SCI.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Fei Tong, Wenchao Shen, Jingjing Zhao, Yonghe Hu, Qi Zhao, Huizhi Lv, Feifan Liu, Zhipeng Meng, Jing Liu
Summary: This study aims to investigate the protective effects of SIRT1 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and reveal its underlying molecular mechanism. The results suggest that SIRT1 protects against LPS-induced ALI by counteracting inflammatory remission and activation of Cav-1 expression via suppressing STAT3. This study reveals the potential importance of SIRT1 in the treatment of ALI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katri Vaparanta, Anne Jokilammi, Ilkka Paatero, Johannes A. Merilahti, Juho Heliste, Karthik Amudhala Hemanthakumar, Riikka Kivela, Kari Alitalo, Pekka Taimen, Klaus Elenius
Summary: In this study, it is demonstrated that Neuregulin-1 (NRG-1) regulates myocardial growth through the STAT5b pathway. Disruption of the NRG-1/ERBB4 pathway or inhibition of Dynamin-2 reduces STAT5b activation and cardiomyocyte hypertrophy. Activation of Stat5 is also observed in NRG-1-induced myocardial growth in zebrafish embryos, and knockdown of stat5b leads to reduced myocardial growth and cardiac function. Furthermore, the NRG-1/ERBB4/STAT5b pathway is differentially regulated in patients with pathological cardiac hypertrophy.
Article
Chemistry, Multidisciplinary
Zheng-nan Ren, Jun Yang, Meng-ya Zhang, Yi-wen Huang, Dong-xiao Song, Xun Sun, Li-long Pan, Jia Sun
Summary: This study demonstrated that (R)-TML104 alleviates experimental pancreatitis by activating AMP-activated protein kinase and inducing SIRT1 expression, which in turn reduces inflammatory cell infiltration. The mechanism involves inhibition of the inflammatory response mediated by the interleukin 6-STAT3 pathway through modulation of SIRT1.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Infectious Diseases
Zhao-Ming Chen, Xiao-Yun Yang, Zheng-Tu Li, Wei-Jie Guan, Ye Qiu, Shao-Qiang Li, Yang-Qing Zhan, Zi-Ying Lei, Jing Liu, Jian-Quan Zhang, Zhong-Fang Wang, Feng Ye
Summary: The presence of anti-IFN-gamma autoantibodies inhibits immune responses of CD4(+) Th1 and CD8(+) T cells, and increases the release of IL-10.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, Research & Experimental
Jiameng Lu, Xiaoqing Ji, Lixia Wang, Fei Sun, Chuanjun Huang, Haiying Peng, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Yanbo Ji, Degan Lu
Summary: This study found that prophylactic administration of IL-27 can improve asthma by restoring the STAT1 and STAT3 pathways, alleviating the Th2 inflammatory environment in the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Chemistry, Medicinal
Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Jiangnan Ye, Huang Chen, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen
Summary: This study describes the design, synthesis, and structure-activity relationship studies of triaromatic heterocyclic derivatives as potent dual phosphorylation STAT3 inhibitors. The best compound 3h (HP590) was discovered with high inhibitory activity against p-Tyr(705) and p-Ser(727), resulting in the growth inhibition of gastric cancer both in vitro and in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wijdan Al-Ahmadi, Thomas S. Webberley, Alex Joseph, Ffion Harris, Yee-Hung Chan, Reem Alotibi, Jessica O. Williams, Alaa Alahmadi, Thomas Decker, Timothy R. Hughes, Dipak P. Ramji
Summary: The study revealed significant impacts of ERK1 deficiency and STAT1 S727A modification on gene expression in macrophages, as well as key processes like inflammation and cell migration. These findings suggest potential therapeutic implications for the regulation of atherosclerosis.
Review
Pharmacology & Pharmacy
Yuhan Su, Tianyu Tao, Xiuxing Liu, Wenru Su
Summary: This review summarizes the diverse roles of the JAK-STAT signaling pathway in ocular homeostasis and non-infectious uveitis (NIU) pathology, and discusses the safety and efficacy of JAK inhibitors for treating NIU and potential approaches for treatment optimization.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Xin Wang, Baokun Zhang, Zhiheng Chen, Qiang Shi, Erzhu Yang, Jianguang Xu, Xiaofeng Lian
Summary: Following spinal cord injury, the disruption of the blood-spinal cord barrier (BSCB) and hemorrhage lead to progressive secondary injuries. Bazedoxifene, a third-generation estrogen receptor modulator, has been found to inhibit inflammation and blood-brain barrier disruption caused by traumatic brain injury. In this study, a new biomaterial carrier was developed to deliver Bazedoxifene to the site of spinal cord injury and effectively attenuate BSCB disruption through the NF-KB pathway, providing potential therapeutic benefits for spinal cord repair.
ACTA BIOMATERIALIA
(2023)
Review
Oncology
Ranzhiqiang Yang, Yinghui Song, Kashif Shakoor, Weimin Yi, Chuang Peng, Sulai Liu
Summary: Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumor with a poor prognosis, characterized by neoplastic transformation of intrahepatic biliary epithelial cells. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that may serve as a target for ICC treatment. Further research is needed to improve understanding of STAT3 and its role in ICC development.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Immunology
Xiaoxue Ma, Shingo Nakayamada
Summary: T follicular helper (Tfh) cells participate in humoral immune responses by promoting inflammation and aiding B cells survival, proliferation, maturation, and generation of autoantibodies. The plasticity of Tfh cells allows for adjustment of differentiation direction based on immune response level, regulated by various signaling factors such as cytokines, receptors, transcription factors, and genes. The STAT family signaling pathways play a crucial role in Tfh formation, with each member contributing to Tfh differentiation through mutual restraint and cooperation among cytokine-STAT signals.
FRONTIERS IN IMMUNOLOGY
(2021)
