Editorial Material
Immunology
Laurence Morel
Summary: Erythrocytes from lupus patients that fail to switch metabolic pathways retain their mitochondria, becoming a novel source of IFN when phagocytosed by macrophages.
TRENDS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hanna Nosek, Dorota Jankowska, Karolina Brzozowska, Katarzyna Kazberuk, Anna Wasilewska, Katarzyna Taranta-Janusz
Summary: This study indicates that TWEAK and RANTES may serve as potential markers of renal impairment in children with solitary functioning kidney.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
A. Celikkol, A. Demirkiran, C. Aydin
Summary: The study suggests that plasma TWEAK levels are elevated earlier in the acute phase and decrease earlier after PPCI in patients with STEMI, compared to other classic myocardial biomarkers.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Rheumatology
Zhi-Hui Wang, Zi-Wei Dai, Yuan-Yuan Dong, Hong Wang, Fei-Fei Yuan, Bin Wang, Dong-Qing Ye
Summary: This meta-analysis evaluated the diagnostic value of uTWEAK for lupus nephritis (LN) and found that uTWEAK has moderate sensitivity and specificity for diagnosing and evaluating activity in LN, indicating its potential as a helpful biomarker for LN.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Peter Korsten, Bjoern Tampe
Summary: Recent research has shown that in systemic lupus erythematosus (SLE), the tubulointerstitial expression of type I interferon IFNA5 is associated with proteinuria in lupus nephritis, while other type I interferons expressed in the glomerular compartment are not correlated. This finding is important for understanding the mechanism and treatment of lupus nephritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Li-ying He, Shu-qi Niu, Cai-xia Yang, Pan Tang, Jiao-jiao Fu, Li Tan, Yong Li, Ya-nan Hua, Si-jing Liu, Jin-lin Guo
Summary: This study aimed to examine the therapeutic potential of Cordyceps proteins (CP) in lupus nephritis (LN) and uncover the underlying molecular mechanism. The results showed that CP had a favorable bidirectional immunomodulatory effect, reducing proteinuria, renal inflammation, and fibrosis in LN mice. CP's regulatory effects surpassed artificial Cordyceps fungus powder (BC) and prednisolone acetate (PA), modulating the STAT3/mTOR/NF-kB signaling pathway and lowering the levels of IL-6 and IL-1 beta.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yiyao Deng, Ying Zheng, Delun Li, Quan Hong, Min Zhang, Qinggang Li, Bo Fu, Lingling Wu, Xu Wang, Wanjun Shen, Yingjie Zhang, Jiakai Chang, Kangkang Song, Xiaomin Liu, Shunlai Shang, Guangyan Cai, Xiangmei Chen
Summary: Through single-cell RNA sequencing analysis, it was found that monocytes, B cells, dendritic cells, and granulocytes were significantly increased in SLE patients, while subsets of T cells were significantly decreased. Neutrophils and low-density granulocytes exhibited the highest ISG activity. 31 common ISGs were found expressed in both PBMCs and kidneys, and these ISGs were also most active in neutrophils and LDGs.
Article
Environmental Sciences
Bijing Yang, Yingwei Liu, Yangwei Li, Shanshan Zhu, Yuanliang Li, Jiangnan Yi, Zhuanxu Ouyang, Bingxian Liu, Khalid Mehmood, Riaz Hussain, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Guanhua Wang, Ying Li, Hui Zhang
Summary: The study found that exposure to Butachlor induces liver damage in mice, characterized by hepatocyte swelling, disordered arrangement, and increased serum enzyme concentrations. Additionally, Butachlor exposure disrupts lipid metabolism, abnormal autophagy, and apoptosis mechanisms leading to hepatotoxicity.
Article
Rheumatology
Taro Iwamoto, Jessica M. Dorschner, Shanmugapriya Selvaraj, Valeria Mezzano, Mark A. Jensen, Danielle Vsetecka, Shreyasee Amin, Ashima Makol, Thomas Osborn, Kevin Moder, Vaidehi R. Chowdhary, Peter Izmirly, H. Michael Belmont, Robert M. Clancy, Jill P. Buyon, Ming Wu, Cynthia A. Loomis, Timothy B. Niewold
Summary: This study found an association between high serum IFN and subtypes of lupus nephritis, and investigated the effect of IFN on renal tissues and cells.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Immunology
Ryan M. Baxter, Christine S. Wang, Josselyn E. Garcia-Perez, Daniel S. Kong, Brianne M. Coleman, Valentyna Larchenko, Ronald P. Schuyler, Conner Jackson, Tusharkanti Ghosh, Pratyaydipta Rudra, Debdas Paul, Manfred Claassen, Rosemary Rochford, John C. Cambier, Debashis Ghosh, Jennifer C. Cooper, Mia J. Smith, Elena W. Y. Hsieh
Summary: The expansion of extrafollicular B cells is closely related to disease activity in childhood-onset lupus nephritis (cLN), suggesting that the interaction between extrafollicular T and B cells plays a role in the pathogenesis of pediatric renal diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Maliha Ahmed, Tanzy Love, Catherine Moore, Thu H. Le, Jerome Jean-Gilles, Bruce Goldman, Hae Yoon Grace Choung
Summary: Some patients without overt systemic lupus erythematosus (SLE) present with lupus nephritis-like biopsy findings. It remains unclear how to classify or treat these patients. Lupus-like nephritis (LLN) may be a manifestation of an autoimmune process that overlaps with SLE.
Article
Oncology
Jingxue Ma, Qiming Gong, Xiuhong Pan, Pengwei Guo, Linlin He, Yanwu You
Summary: Research showed that in lupus-prone BALB/c female mice, FKN levels increased while p38 and FOXP3 levels decreased. Treatment with anti-FKN antibody and p38MAPK inhibitor improved proteinuria and renal function, reduced serum autoantibody levels, and increased renal FOXP3 levels. Furthermore, FKN depletion and p38MAPK inhibitor decreased Treg cell apoptosis, reduced levels of apoptotic factors, and increased levels of anti-apoptotic factors.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yi-Cheng Chen, Pin-Yu Kuo, Yu-Chi Chou, Hao-Earn Chong, Yu-Tung Hsieh, Mei-Lin Yang, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wang
Summary: Accelerated cell apoptosis with dysregulated long noncoding RNAs is the crucial pathogenesis in lupus nephritis (LN). Pro-apoptotic lincRNA-p21 was found to be up-regulated in LN, positively correlated with disease activity, while miR-181a levels were down-regulated and negatively correlated with activity. Modulating the expression of lincRNA-p21 was shown to affect apoptosis and miR-181a levels in experimental models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bogdan Obrisca, Bogdan Sorohan, Liliana Tuta, Gener Ismail
Summary: SLE is an autoimmune disorder caused by a loss of tolerance to endogenous nuclear antigens, triggering an aberrant autoimmune response. LN, a major cause of morbidity and mortality in SLE patients, has seen recent advancements in understanding its genetic and molecular basis, leading to the development of newer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Makayla P. Brady, Saiteja Chava, Shweta Tandon, Madhavi J. Rane, Michelle T. Barati, Dawn J. Caster, David W. Powell
Summary: The measurement of IP-10 levels in serum and urine shows promise in monitoring the activity of lupus nephritis (LN), differentiating between classifications of LN, and distinguishing LN from other forms of glomerular disease. Further assessment of elevated IP-10 levels in high-risk populations, such as African Americans, could help determine why these patients have worse outcomes and are unresponsive to standard therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Dermatology
Jinlu Ma, Wentian Lu, Dong Yan, Zhichun Liu, Leixi Xue
DERMATOLOGIC THERAPY
(2022)
Article
Rheumatology
Wentian Lu, Ying Zhong, Chenghua Weng, Qing Wang, Mei Tang, Zhichun Liu, Leixi Xue
Summary: This study compared the diagnostic performance of three different versions of classification criteria in Chinese patients with SLE and found that SLICC-2012 and EULAR/ACR-2019 showed good early diagnosis ability.
LUPUS SCIENCE & MEDICINE
(2022)
Letter
Rheumatology
Gang Wang, Ning Zhuo, Mei Tang, Leixi Xue, Zhichun Liu
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Ying Zhong, Zhichun Liu, Jinlu Ma, Lin Zhang, Leixi Xue
Summary: This retrospective study aimed to investigate the relationship between tumour-associated antigens (TAAs) and the clinical manifestations and serological markers of SLE. The results showed that SLE patients had higher positivity rates for TAAs such as CA19-9 and CYFRA21-1, and elevated levels of CA125, CA15-3, and CYFRA21-1. Thrombocytopenia and serum creatinine levels were identified as independent risk factors for TAA positivity in SLE patients. In addition, CA125 positivity rate and serum CA125 levels were associated with SLE disease activity.
Letter
Rheumatology
Gang Wang, Ning Zhuo, Ying Luo, Leixi Xue, Mei Tang, Zhichun Liu
ARTHRITIS & RHEUMATOLOGY
(2023)