Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function

(2019) Li Wang et al.   MOLECULAR PSYCHIATRY

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder

(2018) Elizabeth L. Berg et al.   Autism Research

USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels

(2018) Meghan Kerrisk Campbell et al.   JOURNAL OF NEUROSCIENCE

Shank3-deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties

(2018) Mengye Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

(2018) Haitham Amal et al.   MOLECULAR PSYCHIATRY

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Histone deacetylase inhibitor MS-275 restores social and synaptic function in a Shank3-deficient mouse model of autism

(2018) Kaijie Ma et al.   NEUROPSYCHOPHARMACOLOGY

SHANK genes in autism: Defining therapeutic targets

(2018) Adele Mossa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations

(2018) Silvia De Rubeis et al.   Molecular Autism

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

(2018) Alexandra L. Bey et al.   Translational Psychiatry

Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

(2018) Seungjoon Lee et al.   Frontiers in Molecular Neuroscience

Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models

(2018) Christopher Heise et al.   Frontiers in Molecular Neuroscience

Mouse models as a tool for discovering new neurological diseases

(2018) Qiumin Tan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

(2018) Chunmei Jin et al.   Frontiers in Molecular Neuroscience

Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder

(2018) Chantell Balaan et al.   BEHAVIOURAL BRAIN RESEARCH

Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice

(2018) Chantelle Fourie et al.   Frontiers in Cellular Neuroscience

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities

(2018) Taesun Yoo et al.   Frontiers in Cellular Neuroscience

Shank3B mutant mice display pitch discrimination enhancements and learning deficits

(2018) Amanda R. Rendall et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

(2017) Wenting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

(2017) Johanna Lilja et al.   NATURE CELL BIOLOGY

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

(2017) Hala Harony-Nicolas et al.   eLife

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

(2017) Sameer C. Dhamne et al.   Molecular Autism

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

(2017) Yeunkum Lee et al.   Frontiers in Molecular Neuroscience

Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function

(2016) Thomas C. Jaramillo et al.   Autism Research

The contribution of ultrasonic vocalizations to mouse courtship

(2016) SE Roian Egnor et al.   CURRENT OPINION IN NEUROBIOLOGY

The spectrum of epilepsy and electroencephalographic abnormalities due toSHANK3loss-of-function mutations

(2016) J. Lloyd Holder et al.   EPILEPSIA

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

(2016) C Vicidomini et al.   MOLECULAR PSYCHIATRY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

(2016) Rui T Peixoto et al.   NATURE NEUROSCIENCE

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

(2016) F. Yi et al.   SCIENCE

Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus

(2016) Christopher Heise et al.   Frontiers in Cellular Neuroscience

Altered Striatal Synaptic Function and Abnormal Behaviour inShank3Exon4-9 Deletion Mouse Model of Autism

(2015) Thomas C. Jaramillo et al.   Autism Research

Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist

(2015) Ekrem Dere et al.   BEHAVIOURAL BRAIN RESEARCH

Phelan McDermid Syndrome

(2015) Hala Harony-Nicolas et al.   JOURNAL OF CHILD NEUROLOGY

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

(2015) Carlo Sala et al.   JOURNAL OF NEUROCHEMISTRY

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

(2015) H. E. Speed et al.   JOURNAL OF NEUROSCIENCE

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

(2015) Jiseok Lee et al.   Frontiers in Cellular Neuroscience

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID

(2015) Daniela M Cochoy et al.   Molecular Autism

Whole Genome Sequencing Reveals a De Novo SHANK3 Mutation in Familial Autism Spectrum Disorder

(2015) Sergio I. Nemirovsky et al.   PLoS One

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice

(2014) Alipi V. Naydenov et al.   NEURON

Seizures and EEG pattern in the 22q13.3 deletion syndrome: Clinical report of six Italian cases

(2014) Maria Grazia Figura et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders

(2013) Li Zhu et al.   HUMAN MOLECULAR GENETICS

SHANK3Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region

(2013) Marie Germaine Mameza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of two novelShank3transcripts in the developing mouse neocortex

(2013) Chikako Waga et al.   JOURNAL OF NEUROCHEMISTRY

Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

(2013) M. Kouser et al.   JOURNAL OF NEUROSCIENCE

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

(2013) Latha Soorya et al.   Molecular Autism

Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders

(2012) Luigi Boccuto et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

(2012) Michael J. Schmeisser et al.   NATURE

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability

(2011) Fadi F. Hamdan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice

(2011) Sukchan Lee et al.   NATURE NEUROSCIENCE

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Molecular Mechanisms Generating and Stabilizing Terminal 22q13 Deletions in 44 Subjects with Phelan/McDermid Syndrome

(2011) Maria Clara Bonaglia et al.   PLoS Genetics

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Modulation of long-term memory for object recognition via HDAC inhibition

(2009) D. P. Stefanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES