Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice

Cell-Type-SpecificShank2Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes

(2018) Ryunhee Kim et al.   JOURNAL OF NEUROSCIENCE

Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells

(2018) Tetsuya Tatsukawa et al.   NEUROBIOLOGY OF DISEASE

Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice

(2018) Wei Cao et al.   NEURON

SHANK genes in autism: Defining therapeutic targets

(2018) Adele Mossa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

(2018) Federica Filice et al.   Molecular Autism

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures

(2017) Sattar Khoshkhoo et al.   NEURON

Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice

(2017) Chae-Seok Lim et al.   NEUROPHARMACOLOGY

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

(2017) Aslihan Selimbeyoglu et al.   Science Translational Medicine

Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms

(2017) Alexandra Clemente-Perez et al.   Cell Reports

Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism

(2017) Sameer C. Dhamne et al.   Molecular Autism

The contribution of ultrasonic vocalizations to mouse courtship

(2016) SE Roian Egnor et al.   CURRENT OPINION IN NEUROBIOLOGY

Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects

(2016) Fengping Dong et al.   HUMAN MOLECULAR GENETICS

Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors

(2016) S. Ha et al.   JOURNAL OF NEUROSCIENCE

Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness

(2016) O R Homann et al.   MOLECULAR PSYCHIATRY

Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling

(2016) Jinwei Zhu et al.   NATURE REVIEWS NEUROSCIENCE

Selective Localization of Shanks to VGLUT1-Positive Excitatory Synapses in the Mouse Hippocampus

(2016) Christopher Heise et al.   Frontiers in Cellular Neuroscience

Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

(2016) Saša Peter et al.   Nature Communications

Parvalbumin and autism: different causes, same effect?

(2016) Federica Filice et al.   Oncotarget

Prenatal Valproate Exposure Differentially Affects Parvalbumin-Expressing Neurons and Related Circuits in the Cortex and Striatum of Mice

(2016) Emanuel Lauber et al.   Frontiers in Molecular Neuroscience

Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders

(2015) Michael J. Schmeisser   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist

(2015) Ekrem Dere et al.   BEHAVIOURAL BRAIN RESEARCH

Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons

(2015) Wenjie Mao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

(2015) Carlo Sala et al.   JOURNAL OF NEUROCHEMISTRY

Parvalbumin-Positive Inhibitory Interneurons Oppose Propagation But Favor Generation of Focal Epileptiform Activity

(2015) M. Sessolo et al.   JOURNAL OF NEUROSCIENCE

Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders

(2015) S A Barnes et al.   MOLECULAR PSYCHIATRY

Rare SHANK2 variants in schizophrenia

(2015) S Peykov et al.   MOLECULAR PSYCHIATRY

The role of SHANK2 rare variants in schizophrenia susceptibility

(2015) J Costas   MOLECULAR PSYCHIATRY

Identification and functional characterization of rare SHANK2 variants in schizophrenia

(2015) S Peykov et al.   MOLECULAR PSYCHIATRY

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Loss of MeCP2 in Parvalbumin-and Somatostatin-Expressing Neurons in Mice Leads to Distinct Rett Syndrome-like Phenotypes

(2015) Aya Ito-Ishida et al.   NEURON

The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles

(2015) Daniel Vogt et al.   Cell Reports

Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities

(2015) M Wöhr et al.   Translational Psychiatry

Differential Distribution of Shank and GKAP at the Postsynaptic Density

(2015) Jung-Hwa Tao-Cheng et al.   PLoS One

Repetitive behaviors in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

(2014) A. Özge Sungur et al.   JOURNAL OF NEUROSCIENCE METHODS

ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice

(2014) Alipi V. Naydenov et al.   NEURON

Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation

(2014) Nadine Gogolla et al.   NEURON

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

GABAergic Signaling as Therapeutic Target for Autism Spectrum Disorders

(2014) Giada Cellot et al.   Frontiers in Pediatrics

The Autism ProSAP1/Shank2 mouse model displays quantitative and structural abnormalities in ultrasonic vocalisations

(2013) Elodie Ey et al.   BEHAVIOURAL BRAIN RESEARCH

Dysfunction ofSHANK2andCHRNA7in a patient with intellectual disability and language impairment supports genetic epistasis of the two loci

(2013) B Chilian et al.   CLINICAL GENETICS

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

Breakpoint mapping by next generation sequencing reveals causative gene disruption in patients carrying apparently balanced chromosome rearrangements with intellectual deficiency and/or congenital malformations

(2013) Caroline Schluth-Bolard et al.   JOURNAL OF MEDICAL GENETICS

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study

(2012) Anita Rauch et al.   LANCET

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

(2012) Michael J. Schmeisser et al.   NATURE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks

(2012) Peter J. Uhlhaas et al.   NEURON

A Discovery Resource of Rare Copy Number Variations in Individuals with Autism Spectrum Disorder

(2012) Aparna Prasad et al.   G3-Genes Genomes Genetics

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology

(2011) Simone Berkel et al.   HUMAN MOLECULAR GENETICS

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

The Origins of Cortical Interneurons: Mouse versus Monkey and Human

(2009) E. G. Jones   CEREBRAL CORTEX

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

(2009) Nadine Gogolla et al.   Journal of Neurodevelopmental Disorders

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Development of a mouse test for repetitive, restricted behaviors: Relevance to autism

(2008) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Multiple distinct subtypes of GABAergic neurons in mouse visual cortex identified by triple immunostaining

(2008) Yuri Gonchar   Frontiers in Neuroanatomy