Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

(2018) Luye Qin et al.   NATURE NEUROSCIENCE

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

(2018) Alexandra L. Bey et al.   Translational Psychiatry

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylation of CYFIP2, a component of the WAVE-regulatory complex, regulates dendritic spine density and neurite outgrowth in cultured hippocampal neurons potentially by affecting the complex assembly

(2017) Yeunkum Lee et al.   NEUROREPORT

Age-dependent decrease of GAD65/67 mRNAs but normal densities of GABAergic interneurons in the brain regions of Shank3 -overexpressing manic mouse model

(2017) Bokyoung Lee et al.   NEUROSCIENCE LETTERS

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

(2017) Hala Harony-Nicolas et al.   eLife

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

(2017) Yeunkum Lee et al.   Frontiers in Molecular Neuroscience

Increased Excitatory Synaptic Transmission of Dentate Granule Neurons in Mice Lacking PSD-95-Interacting Adhesion Molecule Neph2/Kirrel3 during the Early Postnatal Period

(2017) Junyeop D. Roh et al.   Frontiers in Molecular Neuroscience

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations

(2017) Yeunkum Lee et al.   Frontiers in Molecular Neuroscience

Proteomic Analysis of Post-synaptic Density Fractions from Shank3 Mutant Mice Reveals Brain Region Specific Changes Relevant to Autism Spectrum Disorder

(2017) Dominik Reim et al.   Frontiers in Molecular Neuroscience

Chronic social defeat reduces myelination in the mouse medial prefrontal cortex

(2017) Michael L. Lehmann et al.   Scientific Reports

Neonatal Maternal Separation Impairs Prefrontal Cortical Myelination and Cognitive Functions in Rats Through Activation of Wnt Signaling

(2016) Youjun Yang et al.   CEREBRAL CORTEX

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

(2016) C Vicidomini et al.   MOLECULAR PSYCHIATRY

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

(2016) Michael Bidinosti et al.   SCIENCE

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

(2016) Xiaoming Wang et al.   Nature Communications

Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses

(2016) Yoonhee Kim et al.   Experimental Neurobiology

Emerging role of synaptic actin-regulatory pathway in the pathophysiology of mood disorders

(2015) Su-Yeon Choi et al.   Animal Cells and Systems

Translational neurobiology in Shank mutant mice - Model systems for neuropsychiatric disorders

(2015) Michael J. Schmeisser   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Phelan McDermid Syndrome

(2015) Hala Harony-Nicolas et al.   JOURNAL OF CHILD NEUROLOGY

Phelan–McDermid Syndrome and SHANK3: Implications for Treatment

(2015) Jesse L. Costales et al.   Neurotherapeutics

Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference

(2015) Su-Yeon Choi et al.   Frontiers in Cellular Neuroscience

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

(2015) Jiseok Lee et al.   Frontiers in Cellular Neuroscience

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders

(2015) Su-Yeon Choi et al.   Molecular Brain

The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis

(2015) Eriko Fujita-Jimbo et al.   Molecular Autism

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

(2014) Stefanie Grabrucker et al.   EXPERIMENTAL NEUROLOGY

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

mTORC1 signaling controls multiple steps in ribosome biogenesis

(2014) Valentina Iadevaia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

(2013) Aleksandr Shcheglovitov et al.   NATURE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Shank mutant mice as an animal model of autism

(2013) J. Yoo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

(2013) Ozlem Bozdagi et al.   Molecular Autism

The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress

(2012) Melanie P. Leussis et al.   BIOLOGICAL PSYCHIATRY

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory

(2012) Qian Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Impaired adult myelination in the prefrontal cortex of socially isolated mice

(2012) Jia Liu et al.   NATURE NEUROSCIENCE

Effect of Schizophrenia Risk-Associated Alleles in SREB2 (GPR85) on Functional MRI Phenotypes in Healthy Volunteers

(2012) Eugenia Radulescu et al.   NEUROPSYCHOPHARMACOLOGY

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

(2011) Chiara Verpelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

(2010) Christian Lüscher et al.   NEURON

Protein translation in synaptic plasticity: mGluR-LTD, Fragile X

(2009) Maggie W Waung et al.   CURRENT OPINION IN NEUROBIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA