Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

(2017) Wenting Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Erbb4 Deletion from Medium Spiny Neurons of the Nucleus Accumbens Core Induces Schizophrenia-Like Behaviors via Elevated GABA A Receptor α1 Subunit Expression

(2017) Hong-Yan Geng et al.   JOURNAL OF NEUROSCIENCE

Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons

(2017) Yanina V. Martos et al.   JOURNAL OF NEUROSCIENCE

Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain

(2017) Samuel W. Hulbert et al.   Neuroscience Bulletin

Cortico–Basal Ganglia Circuit Function in Psychiatric Disease

(2016) Lisa A. Gunaydin et al.   Annual Review of Physiology

Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals

(2016) Sonja Halbedl et al.   JOURNAL OF NEUROCHEMISTRY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

(2016) Rui T Peixoto et al.   NATURE NEUROSCIENCE

Direct Ventral Hippocampal-Prefrontal Input Is Required for Anxiety-Related Neural Activity and Behavior

(2016) Nancy Padilla-Coreano et al.   NEURON

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

The Basal Ganglia in Action

(2016) Henry H. Yin   NEUROSCIENTIST

Striatal Circuits as a Common Node for Autism Pathophysiology

(2016) Marc V. Fuccillo   Frontiers in Neuroscience

Altered Striatal Synaptic Function and Abnormal Behaviour inShank3Exon4-9 Deletion Mouse Model of Autism

(2015) Thomas C. Jaramillo et al.   Autism Research

Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders

(2015) Rachel Wurzman et al.   BEHAVIOURAL BRAIN RESEARCH

Autism-Associated Insertion Mutation (InsG) of Shank3 Exon 21 Causes Impaired Synaptic Transmission and Behavioral Deficits

(2015) H. E. Speed et al.   JOURNAL OF NEUROSCIENCE

Resolving the neural circuits of anxiety

(2015) Gwendolyn G Calhoon et al.   NATURE NEUROSCIENCE

Neurobiology of rodent self-grooming and its value for translational neuroscience

(2015) Allan V. Kalueff et al.   NATURE REVIEWS NEUROSCIENCE

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Prefrontal neuronal circuits of contextual fear conditioning

(2014) R. R. Rozeske et al.   GENES BRAIN AND BEHAVIOR

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

(2014) Stephen A. Allsop et al.   Frontiers in Behavioral Neuroscience

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

Increased Prepulse Inhibition and Sensitization of the Startle Reflex in Autistic Children

(2013) Gitte Falcher Madsen et al.   Autism Research

Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism

(2013) Sheryl S. Moy et al.   BEHAVIOURAL BRAIN RESEARCH

Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism

(2013) Marieke Langen et al.   BIOLOGICAL PSYCHIATRY

Reconceptualizing functional brain connectivity in autism from a developmental perspective

(2013) Lucina Q. Uddin et al.   Frontiers in Human Neuroscience

Functional and structural connectivity of frontostriatal circuitry in Autism Spectrum Disorder

(2013) Sonja Delmonte et al.   Frontiers in Human Neuroscience

Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission

(2013) M. Kouser et al.   JOURNAL OF NEUROSCIENCE

Corticostriatal connectivity and its role in disease

(2013) Gordon M. G. Shepherd   NATURE REVIEWS NEUROSCIENCE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors

(2013) E. Burguiere et al.   SCIENCE

Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

(2013) S. E. Ahmari et al.   SCIENCE

Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency

(2013) Latha Soorya et al.   Molecular Autism

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Aberrant Striatal Functional Connectivity in Children with Autism

(2011) Adriana Di Martino et al.   BIOLOGICAL PSYCHIATRY

Brain structure anomalies in autism spectrum disorder-a meta-analysis of VBM studies using anatomic likelihood estimation

(2011) Thomas Nickl-Jockschat et al.   HUMAN BRAIN MAPPING

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

(2011) Andreas M. Grabrucker et al.   TRENDS IN CELL BIOLOGY

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

The neurobiology of repetitive behavior: Of mice…

(2010) Marieke Langen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The neurobiology of repetitive behavior: …and men

(2010) Marieke Langen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reward circuitry function in autism spectrum disorders

(2010) Gabriel S. Dichter et al.   Social Cognitive and Affective Neuroscience

Changes in the Developmental Trajectories of Striatum in Autism

(2009) Marieke Langen et al.   BIOLOGICAL PSYCHIATRY

Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks

(2008) Henry H. Yin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson's Disease

(2008) S. Taverna et al.   JOURNAL OF NEUROSCIENCE

A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity as Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-Outs

(2008) H.-Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Functional disturbances in the striatum by region-specific ablation of NMDA receptors

(2008) N. Ohtsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA