Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport

Structural basis for functional interactions in dimers of SLC26 transporters

(2019) Yung-Ning Chang et al.   Nature Communications

CryoEM structure of the human SLC4A4 sodium-coupled acid-base transporter NBCe1

(2018) Kevin W. Huynh et al.   Nature Communications

Structure of the mechanosensitive OSCA channels

(2018) Mingfeng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

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Cryo-EM structure of the mechanically activated ion channel OSCA1.2

(2018) Sebastian Jojoa-Cruz et al.   eLife

Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

(2018) Andy KM Lam et al.   eLife

Role of the SLC26A9 Chloride Channel as Disease Modifier and Potential Therapeutic Target in Cystic Fibrosis

(2018) Anita Balázs et al.   Frontiers in Pharmacology

Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism

(2017) Emel Ficici et al.   JOURNAL OF GENERAL PHYSIOLOGY

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

Recent developments in the CCP-EM software suite

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Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Cystic fibrosis gene modifierSLC26A9modulates airway response to CFTR-directed therapeutics

(2016) Lisa J. Strug et al.   HUMAN MOLECULAR GENETICS

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

(2016) Yilmaz Alguel et al.   Nature Communications

The STAS domain of mammalian SLC26A5 prestin harbours an anion-binding site

(2015) G. Lolli et al.   BIOCHEMICAL JOURNAL

Targeting ion channels in cystic fibrosis

(2015) Marcus A. Mall et al.   Journal of Cystic Fibrosis

Variants in Solute Carrier SLC26A9 Modify Prenatal Exocrine Pancreatic Damage in Cystic Fibrosis

(2015) Melissa R. Miller et al.   JOURNAL OF PEDIATRICS

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the anion exchanger domain of human erythrocyte band 3

(2015) T. Arakawa et al.   SCIENCE

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins

(2014) Jing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Conserved structure and domain organization among bacterial Slc26 transporters

(2014) Emma L. R. Compton et al.   BIOCHEMICAL JOURNAL

Structure and insights into the function of a Ca2+-activated Cl− channel

(2014) Veronica Kane Dickson et al.   NATURE

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO3 - transport and reduces survival in CFTR-deficient mice

(2014) Xuemei Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions

(2013) Giovanni Cardone et al.   JOURNAL OF STRUCTURAL BIOLOGY

The SLC26 gene family of anion transporters and channels

(2013) Seth L. Alper et al.   MOLECULAR ASPECTS OF MEDICINE

Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase

(2013) Negah Rahmati et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

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SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation

(2012) Pinelopi Anagnostopoulou et al.   JOURNAL OF CLINICAL INVESTIGATION

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

(2012) Lei Sun et al.   NATURE GENETICS

Prevention of overfitting in cryo-EM structure determination

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REFMAC5 for the refinement of macromolecular crystal structures

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A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

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STAS Domain Structure and Function

(2011) Alok K. Sharma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters

(2011) Ehud Ohana et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and mechanism of the uracil transporter UraA

(2011) Feiran Lu et al.   NATURE

SLC26A9 stimulates CFTR expression and function in human bronchial cell lines

(2010) Martine Avella et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Structure of the Cytosolic Portion of the Motor Protein Prestin and Functional Role of the STAS Domain in SLC26/SulP Anion Transporters

(2010) Elisa Pasqualetto et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a SLC26 Anion Transporter STAS Domain in Complex with Acyl Carrier Protein: Implications for E. coli YchM in Fatty Acid Metabolism

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Slc26a9 Is Inhibited by the R-region of the Cystic Fibrosis Transmembrane Conductance Regulator via the STAS Domain

(2009) Min-Hwang Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia

(2009) Carol A. Bertrand et al.   JOURNAL OF GENERAL PHYSIOLOGY

Slc26a9—Anion Exchanger, Channel and Na+ Transporter

(2009) Min-Hwang Chang et al.   JOURNAL OF MEMBRANE BIOLOGY

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Characterization of SLC26A9, Facilitation of Cl- Transport by Bicarbonate

(2008) Celine Loriol et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Congenital Chloride-losing Diarrhea Causing Mutations in the STAS Domain Result in Misfolding and Mistrafficking of SLC26A3

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Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols

The Solute Carrier 26 Family of Proteins in Epithelial Ion Transport

(2008) Michael R. Dorwart et al.   PHYSIOLOGY

Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach

(2008) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA