Evolution of sequence-defined highly functionalized nucleic acid polymers

Selection of DNA aptamers with two modified bases

(2017) Bharat N. Gawande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase

(2016) Matthew R. Dunn et al.   CHEMBIOCHEM

Impact of Target-Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

(2016) John P. Gibbs et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Versatile Approach Towards Nucleobase-Modified Aptamers

(2015) Fabian Tolle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution of Functional Six-Nucleotide DNA

(2015) Liqin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence-Defined Scaffolding of Peptides on Nucleic Acid Polymers

(2015) Chun Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IL-6 as a keystone cytokine in health and disease

(2015) Christopher A Hunter et al.   NATURE IMMUNOLOGY

Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming

(2015) J. M. Rogers et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A High-Fidelity Codon Set for the T4 DNA Ligase-Catalyzed Polymerization of Modified Oligonucleotides

(2015) Yi Lei et al.   ACS Combinatorial Science

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand

(2014) Amy D. Gelinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

(2014) Shashi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin

(2014) Susan Kühnast et al.   JOURNAL OF LIPID RESEARCH

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Towards XNA nanotechnology: new materials from synthetic genetic polymers

(2014) Vitor B. Pinheiro et al.   TRENDS IN BIOTECHNOLOGY

Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers

(2013) Yuri Imaizumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of high-affinity DNA aptamers using an expanded genetic alphabet

(2013) Michiko Kimoto et al.   NATURE BIOTECHNOLOGY

In vitro selection with artificial expanded genetic information systems

(2013) K. Sefah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging World of Synthetic Genetics

(2012) John C. Chaput et al.   CHEMISTRY & BIOLOGY

The XNA world: progress towards replication and evolution of synthetic genetic polymers

(2012) Vitor B Pinheiro et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers

(2012) Ryan Hili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleoside Triphosphates — Building Blocks for the Modification of Nucleic Acids

(2012) Marcel Hollenstein   MOLECULES

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol

(2012) Evan A. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

(2012) D. R. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

(2011) Paola Lo Surdo et al.   EMBO REPORTS

Expanding the Chemistry of DNA for in Vitro Selection

(2010) Jonathan D. Vaught et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An in vitro translation, selection and amplification system for peptide nucleic acids

(2010) Yevgeny Brudno et al.   Nature Chemical Biology

Recent Progress Toward the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers

(2009) Yevgeny Brudno et al.   CHEMISTRY & BIOLOGY

cDNA display: a novel screening method for functional disulfide-rich peptides by solid-phase synthesis and stabilization of mRNA-protein fusions

(2009) J. Yamaguchi et al.   NUCLEIC ACIDS RESEARCH

A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M 2+ )

(2009) Marcel Hollenstein et al.   NUCLEIC ACIDS RESEARCH

Molecular basis of PCSK9 function

(2008) Gilles Lambert et al.   ATHEROSCLEROSIS