Role of epigenetics in transformation of inflammation into colorectal cancer

miR-24 inhibited the killing effect of natural killer cells to colorectal cancer cells by downregulating Paxillin

(2018) Ling-li Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-β1 exposure

(2018) Zhen Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Colorectal cancer cell–derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway

(2018) Guangyao Dai et al.   BULLETIN DU CANCER

LncRNA AB073614 induces epithelial- mesenchymal transition of colorectal cancer cells via regulating the JAK/STAT3 pathway

(2018) Jinfang Xue et al.   Cancer Biomarkers

Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation

(2018) Lili Chen et al.   CARCINOGENESIS

LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling

(2018) Zehua Bian et al.   CLINICAL CANCER RESEARCH

MicroRNAs 15A and 16–1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors

(2018) Ronghua Liu et al.   GASTROENTEROLOGY

MicroRNA-6869-5p acts as a tumor suppressor via targeting TLR4/NF-κB signaling pathway in colorectal cancer

(2018) Shushan Yan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Risk of gastrointestinal bleeding and benefit from colorectal cancer reduction from long-term use of low-dose aspirin: A retrospective study of 612 509 patients

(2018) Kelvin KF Tsoi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways

(2018) Ai‑Lei Wang et al.   Molecular Medicine Reports

Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

(2018) Katja Zappe et al.   Oxidative Medicine and Cellular Longevity

STAT3 induces colorectal carcinoma progression through a novel miR-572-MOAP-1 pathway

(2018) Nan Wang et al.   OncoTargets and Therapy

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids

(2018) Samaneh K. Sarvestani et al.   Oncotarget

Adipose tissue inflammation and VDR expression and methylation in colorectal cancer

(2018) Daniel Castellano-Castillo et al.   Clinical Epigenetics

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

(2018) Christian Gerecke et al.   Oncotarget

Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1

(2018) Meryem Gülfem Öner et al.   GASTROENTEROLOGY

The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression

(2017) Martha L. Slattery et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Role of cyclooxygenase-2 inhibitors in the survival outcome of colorectal cancer patients: A population-based cohort study

(2017) Wan-Wen Huang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer

(2017) Chengxin Luo et al.   MEDIATORS OF INFLAMMATION

MicroRNA-329 serves a tumor suppressive role in colorectal cancer by directly targeting transforming growth factor beta-1

(2017) Baohuan Li et al.   Molecular Medicine Reports

MicroRNA-1299 is a negative regulator of STAT3 in colon cancer

(2017) Yong Wang et al.   ONCOLOGY REPORTS

Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

(2017) Yongfeng Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway

(2017) Chen Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-105 is involved in TNF-α-related tumor microenvironment enhanced colorectal cancer progression

(2017) Zetao Shen et al.   Cell Death & Disease

Maintenance of cancer stemness by miR-196b-5p contributes to chemoresistance of colorectal cancer cells via activating STAT3 signaling pathway

(2017) Dong Ren et al.   Oncotarget

lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-κB/TS Signaling in Colorectal Cancer

(2017) Peilong Li et al.   Molecular Therapy-Nucleic Acids

Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer

(2017) Marcello Rubino et al.   OncoImmunology

Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study

(2016) M. Song et al.   Cancer Prevention Research

The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice

(2016) Yue Guo et al.   CARCINOGENESIS

Targeted deletion of miR-139-5p activates MAPK, NF-κB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer

(2016) Fangyuan Zou et al.   FEBS Journal

Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer

(2016) CHENG-YUN LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Versatile roles of extracellular vesicles in cancer

(2016) Nobuyoshi Kosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3-NF-κB feedback loops

(2016) T Wang et al.   ONCOGENE

Long noncoding RNAs in digestive system cancers: Functional roles, molecular mechanisms, and clinical implications (Review)

(2016) Min Fu et al.   ONCOLOGY REPORTS

Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?

(2016) Nick E Burr et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Circulating long non-coding HOX transcript antisense intergenic ribonucleic acid in plasma as a potential biomarker for diagnosis of breast cancer

(2016) Yi Zhang et al.   Thoracic Cancer

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer

(2015) M. Abu-Remaileh et al.   CANCER RESEARCH

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

(2015) X. Ma et al.   CANCER RESEARCH

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

(2015) Eduardo Bonavita et al.   CELL

miRNA-15a/16: as tumor suppressors and more

(2015) Enyu Huang et al.   Future Oncology

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

Regulation of the vitamin D receptor gene by environment, genetics and epigenetics

(2015) Donovan Saccone et al.   GENE

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α

(2015) Yanlei Ma et al.   GUT

Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: putative risk markers for colitis-associated cancer

(2015) Christian Gerecke et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells

(2015) Ornella I Selmin et al.   JOURNAL OF NUTRITION

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancers Complicating Inflammatory Bowel Disease

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer

(2015) Inês Cebola et al.   Clinical Epigenetics

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3

(2014) S A A Patel et al.   BRITISH JOURNAL OF CANCER

Loss of the Polycomb Mark from Bivalent Promoters Leads to Activation of Cancer-Promoting Genes in Colorectal Tumors

(2014) M. A. Hahn et al.   CANCER RESEARCH

HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients

(2014) M. Svoboda et al.   CARCINOGENESIS

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer

(2014) Kimmie Ng et al.   JNCI-Journal of the National Cancer Institute

Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

(2014) Catarina Roma-Rodrigues et al.   Biomed Research International

PTGS2 (Cyclooxygenase-2) Expression and Survival among Colorectal Cancer Patients: A Systematic Review

(2013) A. T. Kunzmann et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Declining Risk of Colorectal Cancer in Inflammatory Bowel Disease

(2013) Maurice W. M. D. Lutgens et al.   INFLAMMATORY BOWEL DISEASES

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Vitamin D signalling in adipose tissue

(2012) Cherlyn Ding et al.   BRITISH JOURNAL OF NUTRITION

IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer

(2012) Yi Li et al.   CARCINOGENESIS

Regulatory Function of Trefoil peptides (TFF) on Intestinal Cell Junctional Complexes

(2012) Andrea Buda et al.   CELL COMMUNICATION AND ADHESION

Epigenetics of Colorectal Cancer

(2012) Ajay Goel et al.   GASTROENTEROLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Colorectal Cancer Stem Cells

(2012) Aristides G. Vaiopoulos et al.   STEM CELLS

Nucleosome Structure(s) and Stability: Variations on a Theme

(2011) Andrew J. Andrews et al.   Annual Review of Biophysics

Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

(2011) Mary-Clare Cathcart et al.   CANCER AND METASTASIS REVIEWS

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Epigenetic Alteration of PRKCDBP in Colorectal Cancers and Its Implication in Tumor Cell Resistance to TNF -Induced Apoptosis

(2011) J.-H. Lee et al.   CLINICAL CANCER RESEARCH

Intestinal Inflammation and Cancer

(2011) Thomas A. Ullman et al.   GASTROENTEROLOGY

Expression of the nuclear bile acid receptor/farnesoid X receptor is reduced in human colon carcinoma compared to nonneoplastic mucosa independent from site and may be associated with adverse prognosis

(2011) Sigurd Lax et al.   INTERNATIONAL JOURNAL OF CANCER

Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1

(2011) Ruipeng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation

(2011) Fábio S Lira et al.   Lipids in Health and Disease

Incidence of serious respiratory infections in patients with rheumatoid arthritis treated with tocilizumab

(2011) Daisuke Hoshi et al.   Modern Rheumatology

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

Epigenetics and colorectal cancer

(2011) Victoria Valinluck Lao et al.   Nature Reviews Gastroenterology & Hepatology

Risk of Extra-Intestinal Cancer in Inflammatory Bowel Disease: Meta-Analysis of Population-Based Cohort Studies

(2010) Natalia Pedersen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Prostaglandin E2 modulates components of the Wnt signaling system in bone and prostate cancer cells

(2010) Xin-Hua Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials

(2010) Peter M Rothwell et al.   LANCET

Upregulation of DNA Methyltransferase-Mediated Gene Silencing, Anchorage-Independent Growth, and Migration of Colon Cancer Cells by Interleukin-6

(2010) E. Foran et al.   MOLECULAR CANCER RESEARCH

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy

(2010) A. Biffi et al.   NEUROLOGY

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease-Associated Colorectal Cancer

(2009) R. A. Edwards et al.   CANCER RESEARCH

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

(2009) A. J. Schetter et al.   CARCINOGENESIS

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma

(2009) A. J. Schetter et al.   CLINICAL CANCER RESEARCH

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of COX-2 in intestinal inflammation and colorectal cancer

(2009) D Wang et al.   ONCOGENE

Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation?

(2009) Michael Herfs et al.   TRENDS IN MOLECULAR MEDICINE

DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in Colorectal Cancer and Is a Therapeutic Target of Histone Modifications

(2008) Xia Jiang et al.   CANCER CELL

Methylation of Polycomb Target Genes in Intestinal Cancer Is Mediated by Inflammation

(2008) M. A. Hahn et al.   CANCER RESEARCH

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY