Article
Cell Biology
Yuhua Gao, Tao Han, Cailing Han, Hua Sun, Xiaoxia Yang, Dongmei Zhang, Xinli Ni
Summary: Propofol can protect the intestinal barrier, inhibit bacterial invasion, and increase beneficial bacteria levels. It inhibits the activation of the NF-kappa B pathway by downregulating miR-155 expression, thus reducing inflammatory cytokine secretion.
Article
Biochemistry & Molecular Biology
Aili Li, Jiajie Yang, Chao Zhang, Houyu Chi, Congwei Zhang, Tongtong Li, Jingjing Zhang, Peng Du
Summary: Activation of the TLR4/NF-κB signaling pathway is a crucial mechanism in macrophages during beta-Lg-induced allergic inflammation. La KLDS 1.0738 significantly alleviates allergic inflammation by inhibiting the TLR4 pathway and upregulating miR-146a levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Hougang Xia, Dandan Wang, Xiaohui Guo, Kaidi Wu, Fuwei Huang, Yanjiang Feng
Summary: The study revealed that treatment with CTP could improve functional recovery in SCI mice, suppress apoptosis, alleviate inflammatory response, and oxidative stress. Moreover, CTP was found to regulate the HMGB1/TLR4/NF-kappa B pathway through miR-142, thus providing protective effects against apoptosis, inflammation, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao
Summary: Sevoflurane postconditioning exerts hepatoprotective effects by inhibiting apoptosis, oxidative stress, and inflammatory response, improving survival rates in HIRI mice. Regulation of miR-142 and HMGB1 expression, as well as blocking the TLR4/NF-kappa B pathway activation, contribute to the protective effects of sevoflurane in hepatic I/R injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Maryam Nemati, Saeideh Akseh, Maryam Amiri, Hamid Reza Nejabati, Ahmadreza Jodati, Nazila Fathi Maroufi, Yousef Faridvand, Mohammad Nouri
Summary: The study demonstrated that LF has anti-inflammatory properties by downregulating cytokines such as IL-6 and TNF-alpha, degrading P-p65, reducing HMGB1, TLR4, and MyD88 in the LPS-induced inflammatory response. Additionally, LF also decreased the expression of inflammatory miRNAs mmu-mir-155 and mmu-mir-146a.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Weihua Ren, Fucheng Zhao, Yanru Han, Zhenzhou Liu, Jianli Zhai, Kui Jia
Summary: Through in vitro experiments, we demonstrate for the first time that muscone treatment alleviates cerebral hypoxia injury by blocking activation of the TLR4/NF-kappa B signaling pathway. In the cell model, miR-142-5p is significantly upregulated by muscone treatment, and downregulation of miR-142-5p eliminates the neuroprotective effects of muscone against cerebral hypoxia injury.
Article
Medicine, Research & Experimental
Afsane Bahrami, Maryam Moradi Binabaj, Gordon A. Ferns
Summary: Exosomes are small membrane nano-vesicles derived from cells that carry various components such as lipids, proteins, and nucleic acids. They play a crucial role in tumorigenesis and metastasis, especially by altering signaling pathways to induce colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju
Summary: NF-kappa B is a major regulator of the biological characteristics of tumor cells, and antioxidants or protease inhibitors may suppress colorectal cancer. Computational studies suggest NF-kappa B could be a potential target for anti-cancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Hye Roh, Yeojin Lee, Je-Hyun Yoon, Danbi Lee, Eunju Kim, Eunchong Park, In Young Lee, Tae Sung Kim, Hyun Kyu Song, Jaekyoon Shin, Dae-Sik Lim, Eui-Ju Choi
Summary: MST1/STK4 acts as a negative regulator of the TLR4-NF-kappa B signaling pathway, inhibiting TRAF6 autoubiquitination and downstream signaling, thereby limiting inflammation induced by LPS. The research also suggests that MST1/STK4 can regulate the production of proinflammatory cytokines in macrophages.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
George Notas, Athanasios Panagiotopoulos, Rodanthi Vamvoukaki, Konstantina Kalyvianaki, Foteini Kiagiadaki, Alexandra Deli, Marilena Kampa, Elias Castanas
Summary: ER alpha 36 collaborates with GPER1 to inhibit NF kappa B-mediated inflammation and ER alpha 66 actions in breast cancer cells. Particularly, this effect is more significant in the absence of ER alpha 66. Moreover, overexpression of ER alpha 36 enhances the inhibitory effect of estrogen on inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Han Zhang, Xiang Li, Juan Wang, Qi Cheng, Yunxiao Shang, Guizhen Wang
Summary: Baicalin treatment significantly reduces lung injury induced by Mycoplasma pneumoniae infection, possibly through inhibition of miR-221 expression and regulation of the TLR4/NF-kappa B signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Rui Qian, Xinli Niu, Yinghui Wang, Zhi Guo, Xuyi Deng, Zhenhua Ding, Meijuan Zhou, Haijun Deng
Summary: MALT1 is highly upregulated in colorectal cancer and plays a crucial role in cell proliferation and migration. MiR-375 and miR-365a-3p inhibit NF-κB activation by targeting MALT1, affecting the progression of CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Tao Lin, Ling Ding, Yicheng Lin, Chunbo Liu, Changzhen Wang, Dahao Wu, Zhe Li, Meng Li, Jinlong Sun
Summary: This study found that the use of TLR4 inhibitor TAK-242 can effectively prevent the occurrence of posthemorrhagic hydrocephalus and improve the prognosis. Its mechanism of action involves the regulation of the TLR4-NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Chengfei Zhang, Qiue Zhang, Lingling Qin, Zhiyi Yan, Lili Wu, Tonghua Liu
Summary: This study aimed to investigate the protective effects and potential mechanisms of dioscin in autoimmune thyroiditis. The results showed that dioscin regulated thyroid function, alleviated the pathological process, and suppressed the inflammatory response by inhibiting mTOR and TLR4/NF-κB pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Dermatology
Guo-Yan Liu, Hao Song, Xiu-Lian Xu
JOURNAL OF DERMATOLOGY
(2016)
Article
Computer Science, Artificial Intelligence
Guoyan Liu, Abdurahman Kadir, Hongjun Liu
NEURAL COMPUTING & APPLICATIONS
(2016)
Article
Mathematical & Computational Biology
Guoyan Liu, Hongjun Liu, Abdurahman Kadir
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2012)
Article
Biology
Guoyan Liu, Jie Li, Hongjun Liu
COMPUTERS IN BIOLOGY AND MEDICINE
(2014)
Article
Computer Science, Interdisciplinary Applications
Guoyan Liu, Hongjun Liu, Abdurahman Kadir
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2014)
Article
Dermatology
Xiangfeng Yuan, Dan Meng, Peihua Cao, Lina Sun, Yunyan Pang, Yuan Li, Xing Wang, Zengxiang Luo, Li Zhang, Guoyan Liu
DERMATOLOGIC THERAPY
(2019)
Article
Biochemical Research Methods
Zhao Dong, Guoyan Liu, Guangming Ni, Jason Jerwick, Lian Duan, Chao Zhou
JOURNAL OF BIOPHOTONICS
(2020)
Article
Immunology
Xiangfeng Yuan, Linlin Wang, Dan Meng, Lingyun Wu, Xing Wang, Dong Zhang, Zengxiang Luo, Yunyan Pang, Guoyan Liu
MICROBIAL PATHOGENESIS
(2020)
Article
Nanoscience & Nanotechnology
Lingyun Wu, Guoyan Liu, Wenyu Wang, Ruobing Liu, Lingyan Liao, Ni Cheng, Wentong Li, Weifen Zhang, Dejun Ding
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biochemical Research Methods
Yongyang Huang, Jason Jerwick, Guoyan Liu, Chao Zhou
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Dermatology
Huijuan Meng, Yunyan Pang, Guoyan Liu, Zengxiang Luo, Haiyang Tan, Xiangming Liu
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Dong Zhang, Weifen Zhang, Xinghan Wu, Qian Li, Zhiyi Mu, Fengshuo Sun, Mogen Zhang, Guoyan Liu, Linlin Hu
Summary: A multifunctional drug delivery system was developed for melanoma treatment by incorporating drugs into manganese-doped mesoporous silica nanoparticles, coupled with MRI and photothermal imaging. The system showed excellent drug loading and release efficiency, imaging capability, photothermal heating ability, and demonstrated superior antitumor effect in both in vitro and in vivo experiments, highlighting its potential for melanoma therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haiying Zhao, Guoping Xing, Yingying Wang, Zengxiang Luo, Guoyan Liu, Huijuan Meng
BIOSCIENCE REPORTS
(2017)