Review
Oncology
Alessandro Massano, Luisa Bertin, Fabiana Zingone, Andrea Buda, Pierfrancesco Visaggi, Lorenzo Bertani, Nicola de Bortoli, Matteo Fassan, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Cristina Bezzio, Valentina Casini, Davide Giuseppe Ribaldone, Edoardo Vincenzo Savarino, Brigida Barberio
Summary: This review summarizes the evidence on the association between inflammatory bowel disease (IBD) and extraintestinal cancers (EICs), as well as the safety and management of immunomodulators and biologics for IBD patients with prior or current EICs.
Article
Gastroenterology & Hepatology
Frederikke S. Troelsen, Henrik T. Sorensen, Seth D. Crockett, Lars Pedersen, Rune Erichsen
Summary: In patients with inflammatory bowel disease (IBD), postcolonoscopy colorectal cancers (PCCRC) account for 50% of cases and have distinct characteristics, while the survival rates are similar to those of colorectal cancer (dCRC) with immediate diagnosis after colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Hui Gao, Shuhao Zheng, Xin Yuan, Jiarong Xie, Lei Xu
Summary: This study identified a potential casual relationship between inflammatory bowel disease (IBD) and the development of oral cavity and breast cancer based on Mendelian randomization analysis.
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mika Nakayama, Yuki Ozato, Yoshiko Tsuji, Yasuko Arao, Chihiro Otsuka, Yumiko Hamano, Genzo Sumi, Ken Ofusa, Shizuka Uchida, Andrea Vecchione, Hideshi Ishii
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by damage to the intestinal mucosa. Recent studies have shown the involvement of RNA modifications in the specific pathogenesis of IBD. RNA modification-targeting reagents have shown promising outcomes in treating colitis. Understanding RNA modifications in IBD could contribute to early diagnosis, disease monitoring, and innovative therapeutic approaches.
Article
Rheumatology
Clare Harris, J. R. Fraser Cummings
Summary: Primary non-response and secondary loss of response are still significant issues with current treatment options for inflammatory bowel disease, highlighting the need for new therapeutic choices. As our understanding of IBD pathogenesis advances, new therapeutic targets are being identified.
Review
Medicine, General & Internal
Elizabeth A. A. Spencer, Manasi Agrawal, Tine Jess
Summary: This article reviews the available predictors of outcomes in IBD patient and emphasizes the importance of global collaborative efforts and tools to support the clinical use of these prognostication tools.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Bing Chen, Lauren V. Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J. Lavie, Chayakrit Krittanawong
Summary: This article reviews the association between chronic inflammatory bowel disease and atherosclerotic cardiovascular diseases, heart failure, and atrial fibrillation. The mechanisms underlying this association may involve shared risk factors and pathophysiology. A multidisciplinary team is needed for optimal care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Cell & Tissue Engineering
Yusuke Wakisaka, Shinya Sugimoto, Toshiro Sato
Summary: This review discusses the application of adult tissue-derived organoids culture technology to elucidate the pathogenesis of IBD and to develop novel therapies, including regenerative treatments.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Pharmacology & Pharmacy
Linshan Duan, Shuyu Cheng, Long Li, Yanling Liu, Dan Wang, Guoyan Liu
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by various factors, with Crohn's disease and ulcerative colitis being the two major types. Most commonly used drugs for IBD have adverse reactions and limited long-term efficacy, leading to challenges in treating patients. Research suggests that natural compounds with anti-inflammatory activities could offer potential therapeutic strategies for IBD.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Chih-Hsing Hung, Yi-Ching Lin, Yu-Han Chang, Yu-Chih Lin, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Ming-Feng Hou
EUROPEAN JOURNAL OF CANCER PREVENTION
(2019)
Article
Food Science & Technology
Chien-Hua Chiang, Hei-Hwa Lee, Bai-Hsiun Chen, Yi-Ching Lin, Yu-Ying Chao, Yeou-Lih Huang
JOURNAL OF FOOD AND DRUG ANALYSIS
(2019)
Article
Endocrinology & Metabolism
Yi-Ching Lin, Yen-Chun Chen, Hui-Pin Hsiao, Chang-Hung Kuo, Bai-Hsiun Chen, Yi-Ting Chen, Shih-Ling Wang, Mei-Lan Tsai, Chih-Hsing Hung
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Neurosciences
Ming-Chu Feng, Yi-Ching Lin, Yu-Han Chang, Chun-Hung Chen, Hsiu-Chu Chiang, Ling-Chun Huang, Yuan-Han Yang, Chih-Hsing Hung
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Article
Immunology
Yi-Ching Lin, Yen-Chun Chen, Chang-Hung Kuo, Yu-Han Chang, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Ming-Yii Huang, Chih-Hsing Hung
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chia-Chun Tseng, Man-Chun Wong, Wei-Ting Liao, Chung-Jen Chen, Su-Chen Lee, Jeng-Hsien Yen, Shun-Jen Chang
Summary: Variants of TFBS play a crucial role in regulating gene expression in the human genome, impacting human phenotypes through various mechanisms. However, challenges persist in studying such polymorphisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mei-Lan Tsai, Yi-Giien Tsai, Yu-Chih Lin, Ya-Ling Hsu, Yi-Ting Chen, Ming-Kai Tsai, Wei-Ting Liao, Yi-Ching Lin, Chih-Hsing Hung
Summary: This study demonstrates that IL-25 stimulation induces ROS production and promotes M2 macrophage polarization in monocytes by activating AMPK and inducing mitophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Yi-Giien Tsai, Chao-Hung Kuo, Chih-Hsing Hung
Summary: IL-33 induces ROS production in monocytes and regulates mitophagy through the AMPK pathway. IL-33 also alters the polarization phenotype of monocytes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Chung-Hsiang Li, Mei-Lan Tsai, Hsin-Ying (clair) Chiou, Yi-Ching Lin, Wei-Ting Liao, Chih-Hsing Hung
Summary: This article explores the pathogenesis of asthma and the negative impact of air pollution on asthma outcomes, with a focus on the role of macrophages in patients with asthma exposed to air pollutants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Hua-Yu Hsu, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Huey-Ling You, Yu-Chih Lin, Wei-Ting Liao, Yi-Ching Lin
Summary: Arsenic can promote macrophage polarization to M2 type, resulting in the epithelial-mesenchymal transition of lung epithelial cells. This study found that arsenic induces repolarization of M1 macrophages to M2 macrophages through the autophagy/mitophagy pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Cheng-Che Chen, Chung-Jen Chen
Summary: New-onset inflammatory arthritis after COVID-19 vaccination is more common in females and older patients. Although COVID-19 vaccines may lead to inflammatory arthritis, the benefits of vaccination substantially outweigh the potential risks of such serious adverse effects due to their rarity.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, Research & Experimental
Shih-Yun Hsu, Frank Art Lin, Chung-Jen Chen
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Feng-Shuo Yang, Hei-Hwa Lee, Li-Ping Tseng, Yung-Hung Lee, Yung-Sheng Lan, Yi-Cheng Lee, Yi-Cheng Chou, Yi-Ching Lin
Summary: This study investigated the stability of ten new psychoactive substances (NPSs) in urine and methanol/water at different storage temperatures. The results showed that some substances exhibited excellent stability in urine, even after storing for 90 days at different temperatures. However, for synthetic cathinones, the concentrations declined over time in urine but remained relatively stable in methanol with 0.1% formic acid.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ming-Kai Tsai, Mei-Lan Tsai, Zhi-Hong Wen, Wei-Ting Liao, Yi-Ching Lin, Hsin-Ying Clair Chiou, Ming-Hong Lin, Chih-Hsing Hung
Summary: This study demonstrated that 4-PSB-2 has an anti-inflammatory effect on CCL-1 production, possibly through intracellular signaling pathways and epigenetic regulation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
