Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention

Effect of Eicosapentaenoic Acid on E-type Prostaglandin Synthesis and EP4 Receptor Signaling Human Colorectal Cancer Cells

(2015) Gillian Hawcroft et al.   NEOPLASIA

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment

(2011) Benjamin B. Davis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

(2011) R. E. Carroll et al.   Cancer Prevention Research

Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APC 468 Mice

(2011) E. C. Cheon et al.   CANCER RESEARCH

Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer

(2011) Mainak Mal et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Prostaglandin E2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells

(2010) Hiromichi Fujino et al.   BIOCHEMICAL PHARMACOLOGY

The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia

(2010) Yasmin Hernandez et al.   BMC GASTROENTEROLOGY

Cytochrome P450-derived eicosanoids: the neglected pathway in cancer

(2010) Dipak Panigrahy et al.   CANCER AND METASTASIS REVIEWS

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

HEF1 Is a Crucial Mediator of the Proliferative Effects of Prostaglandin E2 on Colon Cancer Cells

(2010) D. Xia et al.   CANCER RESEARCH

Histone Deacetylase Inhibitors and 15-Deoxy- 12,14-Prostaglandin J2 Synergistically Induce Apoptosis

(2010) M. Koyama et al.   CLINICAL CANCER RESEARCH

Inhibition of Hypoxia Inducible Factor-1  by Dihydroxyphenylethanol, a Product from Olive Oil, Blocks Microsomal Prostaglandin-E Synthase-1/Vascular Endothelial Growth Factor Expression and Reduces Tumor Angiogenesis

(2010) E. Terzuoli et al.   CLINICAL CANCER RESEARCH

Activation of the Acute Inflammatory Response Alters Cytochrome P450 Expression and Eicosanoid Metabolism

(2010) K. N. Theken et al.   DRUG METABOLISM AND DISPOSITION

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer

(2010) Farhat V N Din et al.   GUT

Tumor-secreted PGE2Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway

(2010) Xuesong Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of Regulatory T Cells Facilitates Growth of Established Tumors: A Mechanism Involving the Regulation of Myeloid-Derived Suppressor Cells by Lipoxin A4

(2010) B. Zhang et al.   JOURNAL OF IMMUNOLOGY

The Effects of the Stromal Cell-Derived Cyclooxygenase-2 Metabolite Prostaglandin E2 on the Proliferation of Colon Cancer Cells

(2010) S.-W. Park et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells

(2010) A Greenhough et al.   ONCOGENE

PI3-kinase/Wnt association mediates COX-2/PGE2 pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac

(2010) Jasmeet Kaur et al.   TUMOR BIOLOGY

A  -Tocopherol-Rich Mixture of Tocopherols Inhibits Colon Inflammation and Carcinogenesis in Azoxymethane and Dextran Sulfate Sodium-Treated Mice

(2009) J. Ju et al.   Cancer Prevention Research

15d-PGJ2 Induces Apoptosis by Reactive Oxygen Species-mediated Inactivation of Akt in Leukemia and Colorectal Cancer Cells and Shows In vivo Antitumor Activity

(2009) S.-W. Shin et al.   CLINICAL CANCER RESEARCH

Role of Lipoxins and Resolvins as Anti-Inflammatory and Proresolving Mediators in Colon Cancer

(2009) Naveena Janakiram et al.   CURRENT MOLECULAR MEDICINE

Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?

(2009) Glen A Doherty et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cyclooxygenase 2 Modulates Killing of Cytotoxic T Lymphocytes by Colon Cancer Cells

(2009) Quanxin Wang et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers

(2009) Emmanuel S. Antonarakis et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis

(2009) Xiangsheng Zuo et al.   JNCI-Journal of the National Cancer Institute

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

(2009) A. Koeberle et al.   MOLECULAR CANCER THERAPEUTICS

Experimental cancer therapy using restoration of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression

(2009) L. N. Kaliberova et al.   MOLECULAR CANCER THERAPEUTICS

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

Gemcitabine Plus Celecoxib in Patients With Advanced or Metastatic Pancreatic Adenocarcinoma

(2008) Tomislav Dragovich et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APCMin/+ mice

(2008) N. Elander et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2

(2008) Ivonne Löffler et al.   BMC CANCER

Pro-inflammatory prostaglandins and progression of colorectal cancer

(2008) Dingzhi Wang et al.   CANCER LETTERS

Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis

(2008) M. Nakanishi et al.   CANCER RESEARCH

Overexpression of 5-Lipoxygenase in Colon Polyps and Cancer and the Effect of 5-LOX Inhibitors In vitro and in a Murine Model

(2008) L. G. Melstrom et al.   CLINICAL CANCER RESEARCH

Pilot Randomized Phase II Study of Celecoxib in Oral Premalignant Lesions

(2008) V. A. Papadimitrakopoulou et al.   CLINICAL CANCER RESEARCH

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

(2008) Rong-Ying Su et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells

(2008) Yulyana Yudina et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS