Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

(2016) Unmesh Jadhav et al.   CELL

PRC2 preserves intestinal progenitors and restricts secretory lineage commitment

(2016) Fulvio Chiacchiera et al.   EMBO JOURNAL

Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells

(2016) Martijn A.J. Koppens et al.   GASTROENTEROLOGY

Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice

(2016) Wenlong Lin et al.   GUT

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution

(2016) Assaf Weiner et al.   NATURE BIOTECHNOLOGY

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

(2016) Jinjin Xu et al.   Nature Communications

Interleukin-18: The Bouncer at the Mucosal Bar

(2015) Timothy W. Hand   CELL

Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency

(2015) Christina V. Theodoris et al.   CELL

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis

(2015) Huatuo Zhu et al.   Scientific Reports

Linking Immunity, Epigenetics, and Cancer in Inflammatory Bowel Disease

(2014) Jan Däbritz et al.   INFLAMMATORY BOWEL DISEASES

A20 controls intestinal homeostasis through cell-specific activities

(2014) Lars Vereecke et al.   Nature Communications

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis

(2013) Theresa Alenghat et al.   NATURE

Towards personalized care in IBD

(2013) Mark E. Gerich et al.   Nature Reviews Gastroenterology & Hepatology

Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells

(2012) Hideyuki Takeshima et al.   CARCINOGENESIS

A functional methylome map of ulcerative colitis

(2012) R. Hasler et al.   GENOME RESEARCH

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Mucosal genome-wide methylation changes in inflammatory bowel disease

(2012) James Cooke et al.   INFLAMMATORY BOWEL DISEASES

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

(2012) Joshua D. Stender et al.   MOLECULAR CELL

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis

(2012) Jun Qin et al.   NATURE

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

(2012) Rhys S. Allan et al.   NATURE

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL