Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

Brain cholesterol metabolism and Parkinson's disease

(2019) Xuemei Huang et al.   MOVEMENT DISORDERS

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

The level of 24-hydroxycholesteryl esters decreases in plasma of patients with Parkinson’s disease

(2018) Concetta Di Natale et al.   NEUROSCIENCE LETTERS

Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study

(2018) Violetta Rozani et al.   MOVEMENT DISORDERS

Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons

(2018) Xiaofei Wei et al.   NEUROPHARMACOLOGY

In vitrocytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

(2017) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

Possible anti-depressant effect of efavirenz and pro-depressive-like effect of voriconazole in specified doses in various experimental models of depression in mice

(2017) Tejal K. Patel et al.   Pharmacological Reports

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

(2017) Natalia Mast et al.   PLoS One

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

(2017) Fabian Arenas et al.   Frontiers in Molecular Neuroscience

Chromatin-Modifying Agents Increase Transcription of CYP46A1, a Key Player in Brain Cholesterol Elimination

(2017) Inês Milagre et al.   JOURNAL OF ALZHEIMERS DISEASE

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

(2016) Kyle W. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

(2016) Min-Yu Sun et al.   JOURNAL OF NEUROPHYSIOLOGY

The association between CYP46A1 rs4900442 polymorphism and the risk of Alzheimer’s disease: A meta-analysis

(2016) Fengjv Jia et al.   NEUROSCIENCE LETTERS

LXR Regulation of Brain Cholesterol: From Development to Disease

(2016) Rebecca Courtney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The influence of cholesterol on membrane protein structure, function, and dynamics studied by molecular dynamics simulations

(2015) Julie Grouleff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

(2015) Farah Chali et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

(2015) Marie-Anne Burlot et al.   HUMAN MOLECULAR GENETICS

Efavirenz and the CNS: what we already know and questions that need to be answered

(2015) Nadezda Apostolova et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

(2015) Junji Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evidence for altered cholesterol metabolism in Huntington's diseasepost mortembrain tissue

(2015) Fabian Kreilaus et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

(2015) Min-Yu Sun et al.   NEUROSCIENTIST

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin

(2014) Jean E. Vance et al.   JOURNAL OF LIPID RESEARCH

Efavirenz Promotes β-Secretase Expression and Increased Aβ1-40,42 via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND)

(2014) Lecia A. M. Brown et al.   PLoS One

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

(2013) Tomonori Ishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

CYP46A1 intron-2T/C polymorphism and Alzheimer's disease: An updated meta-analysis of 16 studies including 3960 cases and 3828 controls

(2013) Min Li et al.   NEUROSCIENCE LETTERS

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

(2013) Ingemar Björkhem et al.   NEUROSCIENCE LETTERS

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

Association ofCYP46gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis

(2012) Chunhui Jin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies

(2012) Krishna Undela et al.   JOURNAL OF NEUROLOGY

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The NMDA receptor as a target for cognitive enhancement

(2012) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

(2012) Ana M. Sebastião et al.   NEUROPHARMACOLOGY

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter

(2011) Inês Milagre et al.   JOURNAL OF NEUROCHEMISTRY

Whole body cholesterol metabolism is impaired in Huntington's disease

(2011) V. Leoni et al.   NEUROSCIENCE LETTERS

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

(2010) David A Elliott et al.   Clinical Lipidology

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington’s disease

(2010) Daniel Del Toro et al.   JOURNAL OF NEUROCHEMISTRY

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression ofCYP46A1gene transcription

(2010) Maria João Nunes et al.   JOURNAL OF NEUROCHEMISTRY

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme−Product Correlations in Human Retina but Not Human Brain

(2010) Wei-Li Liao et al.   JOURNAL OF PROTEOME RESEARCH

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

(2009) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

(2009) R. W. Halford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors

(2008) Marjan Shafaati et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

(2008) Valerio Leoni et al.   BRAIN

Cholesterol depletion inhibits synaptic transmission and synaptic plasticity in rat hippocampus

(2008) C. Frank et al.   EXPERIMENTAL NEUROLOGY

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins

(2008) Veronica Hirsch-Reinshagen et al.   JOURNAL OF LIPID RESEARCH

Transcriptional regulation of the humanCYP46A1brain-specific expression by Sp transcription factors

(2008) Ins Milagre et al.   JOURNAL OF NEUROCHEMISTRY

Low LDL cholesterol and increased risk of Parkinson's disease: Prospective results from Honolulu-Asia Aging Study

(2008) Xuemei Huang et al.   MOVEMENT DISORDERS

Statin use and the risk of Parkinson disease

(2008) A. D. Wahner et al.   NEUROLOGY

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA