Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

Pyramidal Cell Selective Ablation of N-Methyl-D-Aspartate Receptor 1 Causes Increase in Cellular and Network Excitability

(2015) Valerie M. Tatard-Leitman et al.   BIOLOGICAL PSYCHIATRY

Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel

(2015) Christine M Emnett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

(2015) Farah Chali et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

(2014) Cynthia Fourgeux et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse

(2014) Anna Meljon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting of NMDA receptors in new treatments for schizophrenia

(2014) Kenji Hashimoto   EXPERT OPINION ON THERAPEUTIC TARGETS

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

Pregnenolone sulfate as a modulator of synaptic plasticity

(2014) Conor C. Smith et al.   PSYCHOPHARMACOLOGY

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+-Activated Small Conductance Potassium Channels

(2013) P. Pagadala et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction

(2012) Nicholas L Weilinger et al.   ACTA PHARMACOLOGICA SINICA

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

(2012) Anna Meljon et al.   JOURNAL OF LIPID RESEARCH

Diversity in NMDA Receptor Composition

(2012) Antonio Sanz-Clemente et al.   NEUROSCIENTIST

Analysis of oxysterol metabolomes

(2011) William J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The NMDA receptor complex as a therapeutic target in epilepsy: a review

(2011) Mehdi Ghasemi et al.   EPILEPSY & BEHAVIOR

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key

(2009) Philippe Liere et al.   JOURNAL OF LIPID RESEARCH

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

(2009) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

(2009) Jeffrey Burgdorf et al.   NEUROBIOLOGY OF AGING

Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease

(2008) Sonia Cohen et al.   Annual Review of Cell and Developmental Biology

Synaptic clustering by dendritic signalling mechanisms

(2008) Matthew E Larkum et al.   CURRENT OPINION IN NEUROBIOLOGY

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex

(2008) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA