Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs
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Title
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs
Authors
Keywords
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Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 26, Issue 7, Pages 535-544
Publisher
Springer Science and Business Media LLC
Online
2019-07-04
DOI
10.1038/s41594-019-0252-8
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Note: Only part of the references are listed.- Identification of a bilirubin receptor that may mediate a component of cholestatic itch
- (2019) James Meixiong et al. eLife
- An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking
- (2019) Julia Kozlitina et al. PLoS Genetics
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- (2019) Kanako Terakado Kimura et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ultra-large library docking for discovering new chemotypes
- (2019) Jiankun Lyu et al. NATURE
- Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
- (2018) Tao Che et al. CELL
- 5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology
- (2018) Yao Peng et al. CELL
- Selectivity Challenges in Docking Screens for GPCR Targets and Anti-Targets
- (2018) Dahlia R Weiss et al. JOURNAL OF MEDICINAL CHEMISTRY
- Unexplored therapeutic opportunities in the human genome
- (2018) Tudor I. Oprea et al. NATURE REVIEWS DRUG DISCOVERY
- Biased signalling: from simple switches to allosteric microprocessors
- (2018) Jeffrey S. Smith et al. NATURE REVIEWS DRUG DISCOVERY
- Orphan neuropeptides and receptors: Novel therapeutic targets
- (2018) Lloyd D. Fricker et al. PHARMACOLOGY & THERAPEUTICS
- Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein
- (2018) Javier García-Nafría et al. eLife
- The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats
- (2018) C. Austin Zamarripa et al. DRUG AND ALCOHOL DEPENDENCE
- Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
- (2018) Christopher J. Draper-Joyce et al. NATURE
- Structural insights into G-protein-coupled receptor allostery
- (2018) David M. Thal et al. NATURE
- Crystal structure of the Frizzled 4 receptor in a ligand-free state
- (2018) Shifan Yang et al. NATURE
- Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
- (2018) Sheng Wang et al. NATURE
- Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go
- (2018) Javier García-Nafría et al. NATURE
- Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
- (2018) Yi-Lynn Liang et al. NATURE
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex
- (2018) Yi-Lynn Liang et al. NATURE
- Mechanisms of signalling and biased agonism in G protein-coupled receptors
- (2018) Denise Wootten et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural determinants of 5-HT2B receptor activation and biased agonism
- (2018) John D. McCorvy et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- G protein–coupled receptor kinases (GRKs) orchestrate biased agonism at the β2-adrenergic receptor
- (2018) Minjung Choi et al. Science Signaling
- Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat
- (2018) Dionéia Araldi et al. NEUROSCIENCE
- Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
- (2018) Hongtao Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Far away from the lamppost
- (2018) Tudor I. Oprea et al. PLOS BIOLOGY
- Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
- (2017) Yi-Lynn Liang et al. NATURE
- Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
- (2017) Yan Zhang et al. NATURE
- Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
- (2017) John D McCorvy et al. Nature Chemical Biology
- In silico design of novel probes for the atypical opioid receptor MRGPRX2
- (2017) Katherine Lansu et al. Nature Chemical Biology
- Discovery of new GPCR ligands to illuminate new biology
- (2017) Bryan L Roth et al. Nature Chemical Biology
- Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications
- (2017) Hsin-Pei Shih et al. NATURE REVIEWS DRUG DISCOVERY
- Biopharma deal-making in 2016
- (2017) Amanda Micklus et al. NATURE REVIEWS DRUG DISCOVERY
- Trends in GPCR drug discovery: new agents, targets and indications
- (2017) Alexander S. Hauser et al. NATURE REVIEWS DRUG DISCOVERY
- D4dopamine receptor high-resolution structures enable the discovery of selective agonists
- (2017) Sheng Wang et al. SCIENCE
- Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
- (2017) Mette Trauelsen et al. Molecular Metabolism
- Identifying ligands at orphan GPCRs: current status using structure-based approaches
- (2016) Tony Ngo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Crystal Structure of the Human Cannabinoid Receptor CB 1
- (2016) Tian Hua et al. CELL
- Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment
- (2016) Vivek Kumar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability
- (2016) Rachel Saylor Crowley et al. JOURNAL OF MEDICINAL CHEMISTRY
- Docking Screens for Novel Ligands Conferring New Biology
- (2016) John J. Irwin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists
- (2016) Xin Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2
- (2016) András Váradi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
- (2016) Dean P. Staus et al. NATURE
- Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
- (2016) David M. Thal et al. NATURE
- Structure-based discovery of opioid analgesics with reduced side effects
- (2016) Aashish Manglik et al. NATURE
- Public biotech in 2015 – the numbers
- (2016) Chris Morrison et al. NATURE BIOTECHNOLOGY
- Orphan receptor ligand discovery by pickpocketing pharmacological neighbors
- (2016) Tony Ngo et al. Nature Chemical Biology
- Phase II and phase III failures: 2013–2015
- (2016) Richard K. Harrison NATURE REVIEWS DRUG DISCOVERY
- Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
- (2016) Jie Yin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DREADDs for Neuroscientists
- (2016) Bryan L. Roth NEURON
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- (2016) Jie Yin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure–Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias
- (2015) Kimberly M. Lovell et al. ACS Chemical Neuroscience
- Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily
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- (2015) John A. Christopher et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
- (2015) Xi-Ping Huang et al. NATURE
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
- (2015) Wesley K Kroeze et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice
- (2015) Su M Park et al. NEUROPSYCHOPHARMACOLOGY
- Structure and function of serotonin G protein-coupled receptors
- (2015) John D. McCorvy et al. PHARMACOLOGY & THERAPEUTICS
- PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
- (2015) Wesley K Kroeze et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Polypharmacology: Challenges and Opportunities in Drug Discovery
- (2014) Andrew Anighoro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular control of δ-opioid receptor signalling
- (2014) Gustavo Fenalti et al. NATURE
- Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey
- (2014) Joshua D. Vardigan et al. PSYCHOPHARMACOLOGY
- Structure-Based Discovery of Selective Serotonin 5-HT 1B Receptor Ligands
- (2014) David Rodríguez et al. STRUCTURE
- Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening
- (2013) Ana Negri et al. Journal of Chemical Information and Modeling
- Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain
- (2013) Xiao-Tao Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- GENSAT BAC Cre-Recombinase Driver Lines to Study the Functional Organization of Cerebral Cortical and Basal Ganglia Circuits
- (2013) Charles R. Gerfen et al. NEURON
- Structural Basis for Molecular Recognition at Serotonin Receptors
- (2013) C. Wang et al. SCIENCE
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- Structure-Function of the G Protein–Coupled Receptor Superfamily
- (2012) Vsevolod Katritch et al. Annual Review of Pharmacology and Toxicology
- Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
- (2012) Kazuko Haga et al. NATURE
- Structure of the human κ-opioid receptor in complex with JDTic
- (2012) Huixian Wu et al. NATURE
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- Structure and dynamics of the M3 muscarinic acetylcholine receptor
- (2012) Andrew C. Kruse et al. NATURE
- Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
- (2012) Arvin C. Dar et al. NATURE
- Automated design of ligands to polypharmacological profiles
- (2012) Jérémy Besnard et al. NATURE
- Crystal Structure of a Lipid G Protein-Coupled Receptor
- (2012) M. A. Hanson et al. SCIENCE
- Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
- (2012) W. Liu et al. SCIENCE
- Advancing drug discovery for schizophrenia
- (2011) Stephen R. Marder et al. Annals of the New York Academy of Sciences
- Cardiorenal Actions of TRV120027, a Novel ß-Arrestin–Biased Ligand at the Angiotensin II Type I Receptor, in Healthy and Heart Failure Canines
- (2011) Guido Boerrigter et al. Circulation-Heart Failure
- Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase
- (2011) Kunio S. Misono et al. FEBS Journal
- Structure of the human histamine H1 receptor complex with doxepin
- (2011) Tatsuro Shimamura et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- ChEMBL: a large-scale bioactivity database for drug discovery
- (2011) A. Gaulton et al. NUCLEIC ACIDS RESEARCH
- Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy
- (2011) J. A. Allen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine
- (2011) Andrew S. Doré et al. STRUCTURE
- Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist
- (2010) E. Y. T. Chien et al. SCIENCE
- The Expanded Biology of Serotonin
- (2009) Miles Berger et al. Annual Review of Medicine
- Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors
- (2009) Georgia M. Alexander et al. NEURON
- PubChem: a public information system for analyzing bioactivities of small molecules
- (2009) Y. Wang et al. NUCLEIC ACIDS RESEARCH
- Anatomical Profiling of G Protein-Coupled Receptor Expression
- (2008) Jean B. Regard et al. CELL
- Structure of a β1-adrenergic G-protein-coupled receptor
- (2008) Tony Warne et al. NATURE
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