In silico design of novel probes for the atypical opioid receptor MRGPRX2

The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective

(2016) Sonia Podvin et al.   Annual Review of Pharmacology and Toxicology

Identifying ligands at orphan GPCRs: current status using structure-based approaches

(2016) Tony Ngo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Docking Screens for Novel Ligands Conferring New Biology

(2016) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Recognition of Identical Ligands by Unrelated Proteins

(2015) Sarah Barelier et al.   ACS Chemical Biology

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

(2015) Xi-Ping Huang et al.   NATURE

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

(2015) Casey O’Connor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preliminary Pharmacological Evaluation of Enantiomeric Morphinans

(2014) Anna W. Sromek et al.   ACS Chemical Neuroscience

Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2

(2014) Trevor Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Computer-Aided Discovery of Aromatic l-α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139

(2014) Vignir Isberg et al.   Journal of Chemical Information and Modeling

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

(2014) Ewelina Rojewska et al.   NEUROPHARMACOLOGY

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

(2013) Mathias Rask-Andersen et al.   Annual Review of Pharmacology and Toxicology

 -Defensins Activate Human Mast Cells via Mas-Related Gene X2

(2013) H. Subramanian et al.   JOURNAL OF IMMUNOLOGY

A pharmacological organization of G protein–coupled receptors

(2013) Henry Lin et al.   NATURE METHODS

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4

(2012) M. M. Mysinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights from structural biology into the druggability of G protein-coupled receptors

(2012) Jonathan S. Mason et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A mast cell degranulation screening assay for the identification of novel mast cell activating agents

(2012) Herman F. Staats et al.   MedChemComm

Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

(2011) John A. Allen et al.   Annual Review of Pharmacology and Toxicology

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

(2011) Jens Carlsson et al.   Nature Chemical Biology

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Rapid Context-Dependent Ligand Desolvation in Molecular Docking

(2010) Michael M. Mysinger et al.   Journal of Chemical Information and Modeling

Discovery of Dinaciclib (SCH 727965): A Potent and Selective Inhibitor of Cyclin-Dependent Kinases

(2010) Kamil Paruch et al.   ACS Medicinal Chemistry Letters

Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis

(2009) Leila Malik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Determining the Neurotransmitter Concentration Profile at Active Synapses

(2009) Annalisa Scimemi et al.   MOLECULAR NEUROBIOLOGY

Activation of opioid μ-receptor by sinomenine in cell and mice

(2008) Mao Hsien Wang et al.   NEUROSCIENCE LETTERS

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH

Building alternate protein structures using the elastic network model

(2008) Qingyi Yang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS