Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist

(2018) Wanchao Yin et al.   Cell Discovery

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

A kinetic view of GPCR allostery and biased agonism

(2017) J Robert Lane et al.   Nature Chemical Biology

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Temporal Bias: Time-Encoded Dynamic GPCR Signaling

(2017) Manuel Grundmann et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Recent developments in the CCP-EM software suite

(2017) Tom Burnley et al.   Acta Crystallographica Section D-Structural Biology

A pipeline approach to single-particle processing inRELION

(2017) Rafael Fernandez-Leiro et al.   Acta Crystallographica Section D-Structural Biology

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

(2016) A. J. Venkatakrishnan et al.   NATURE

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

GPCRdb: an information system for G protein-coupled receptors

(2015) Vignir Isberg et al.   NUCLEIC ACIDS RESEARCH

Structure and function of serotonin G protein-coupled receptors

(2015) John D. McCorvy et al.   PHARMACOLOGY & THERAPEUTICS

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Structural Basis for Molecular Recognition at Serotonin Receptors

(2013) C. Wang et al.   SCIENCE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Low-resolution refinement tools inREFMAC5

(2012) Robert A. Nicholls et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Agonist-bound structures of G protein-coupled receptors

(2012) Guillaume Lebon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY